Illustratio Scientiae

One of mine #scientific #illustration from a #paper published on #EpilepsyResearch in 2016 (doi: 10.1016/j.eplepsyres.2016.02.005.). This #simple and #schematic #figure shows a proposed #mechanism for CB-TRPV1 cross-talk in the #MDA. #Neurotransmitter (NT) release is modulated by #presynaptic CBr activation. The different #excitability levels of #DG #neurons could be influenced by: post-synaptic CBr eliciting #inhibitory pathways; #TRPV1, responsible for #cation currents; possible impairment of #CB #system on TRPV1 function. (A), (B), (C), (D): continue arrows indicate the #direct activation of receptors; the barred lines stand for #antagonism or #blockade of a process; dashed arrows show a modulatory action and spotted arrows of different thickness indicate TRPV1-cation currents of different #intensity. Made with #ChembioDraw and #AdobePhotoshop #Science #Neuroscience #medical #biology @thebrainlab @unipait @biology_se @we_love_biology @biology_is_life

One of mine #scientific #illustration published on #Frontiers in #Aging #Neuroscience last year on my #review titled "Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons" (http://dx.doi.org/10.3389/fnagi.2014.00337). It highlights to date known #age-related #electrophysiological and #morphological changes in neurons. In this image i used a #lowpoly #style and #neuron has been depicted as a generic #myelinated #neuron for #simplicity, in order to summarize #information from different #animal models and neuronal cell type. (A) Age-related increase of #altered #neurotransmitter #receptors (gray) and decreased expression of normal ones (green). (B) Representative AP traces of #young and aged neuron. (C) Absence/disruption of #paranodal #ultrastructure (in red) leading K+ channels to be relocated adjacent to “Nav” clusters. (D) #Depletion of #myelin layers (in red) leading to an increase of the occurrence of #redundant myelin #sheaths exposing the enclosed #autodesk Alterations in Na+ and K+ channel properties or subtype expression patterns. Illustration was entirely created and rendered in @Autodesk 3Ds Max 2015. @low.poly @thebrainlab @neuroscienceofficial @anatomianatomy @medicaltalks

#Anencephaly is a #congenital #birth #defect consisting in the absence of a major portion of the #brain, #skull, and #scalp that occurs during #embryonic #development. It is a #cephalic #disorder resulting from a #neural #tube #defect that occurs when the rostral end of the neural tube fails to close. #Children born with this disorder usually only lack a #telencephalon, the largest part of the brain consisting mainly of the cerebral #hemispheres, including the #neocortex, which is responsable for high #cognitive functions. The remaining structure is usually covered only by a thin layer of #membrane— #skin, #bone, #meninges, etc. are all lacking. With very few exceptions, infants with this disorder do not survive longer than a few hours or possibly days after their birth. To date, no #3D high resolution #reconstruction of this kind is available. @3dtam and the Institute of Pathological-Anatomy at @unipait for the very first time pioneered a photogrammetric 3D scan of a 100 years old anencephalic #phoetus included in the collection of the Museum of Pathological-Anatomy of Palermo, Italy. The features of such kind of #specimen make this 3D scan really challenging and time consuming. And if fragility and size made the task difficult already, the wetness of the skin due to its liquid PFA storage, resulted in a nightmare light reflections and scattering other than being extremely unhealthy and dangerous. Acquisition has been made by means of a semi automatic system, consisting in an remote controlled rotating platform, 2 #Canon cameras and 2 flashes with softbox. 241 photos has been used for reconstruction and the whole workflow made by using a #HP envy laptop. Even if the result looks great much more can and will be done. Indeed, we will shortly repeat the task by using crosspolarizing technique which was impossible at that time and a fully automatic rig for the acquisition. Actually, we hope that the use of crosspolarizing technique could improve texture and geometry reconstruction, minimizing ( or better removing) further post-processing work. (at Università degli Studi di Palermo)

#3D #printing is not a #game, and even less if you deal with #hard #metal 3Dprint such as #stainless #steel…refining is a #nightmare made of #dangerous #tools and #reagents. Here on the top you can see a 3D print of a #lowpoly #skull made with #AutodeskMemento right as it came from #shapeways, on the bottom after 2 hours of refining work.

Human Skull by 3DTAM on Sketchfab

Few #screenshot of #wip #first #highres #3D #Stereophotogrammetry #reconstruction of an #acromegalic #skull. The #original #specimen used for 3D reconstruction is part of the #collection of the #Museum of #Pathological #Anatomy of the Università degli Studi of #Palermo @unipait #Italy. Scanned with #canon and processed with @AutodeskMemento @autodesk @autodesk_me #science #medical #pathology #anatomy #desease #oddity #freak #bone #overgrowth #instapic #picoftheday #instadaily (at Palermo, Italy)

My #favourite #medical #museum in #turin… #instatrip #Italy #instatravel #picoftheday #anatomy #criminology #lombroso #skull #skeleton #science (presso Museo Antropologia Criminale Cesare Lombroso)

A little #memory of one of the most #intense and well organized #exhibition of #mummies i have never seen. #Stunning #Specimen collected from all over the world ranging from #Europe to #southamerica! #spain #digital #Heritage #2015 #instatrip #instagram #instatravel #instaoddities #oddities #mummy #collection #history #science #medical #human #anatomy #congress #conference (presso Parque de las Ciencias)

A #real #human #anatomical #3D #printed #replica cannot be made by anything else than #stainless #steel . My self-made #Christmas #gifts. #Rip #Fix and #Fab with @autodesk #Memento #science #anatomy #medical #normal #palermo #Italy #surgery @skullcollecting @low.poly @unipait @tatjanadzambazova @autodesk_me @illustratedmonthly @asylumartwork @artprintnews @anatomianatomy @morbidanatomy (presso Istituto Di Fisiologia Umana)

#Stereophotogrammetry on a standing #giant 's #skull is surely the most #difficult one i have made so far! Next time i will go for a #hobbit 😜...Tired but #happy! Now photos check and then #Autodesk #Memento will do the #craft! Stay Tuned! #3D #scan at #museum of #Pathological #Anatomy @unipait #acromegaly #oddities #skeleton #specimen #gprotein #abnormality #medicine #science #3dtam #application #reconstruction #digital #preservation #heritage #palermo #Italy #educational #nonprofit #student (presso Palermo, Italy)

#Instapic #instadaily #big #event #lasvegas #autodeskuniversity2015 #capturereality #booth

#3D #reconstruction #portrait #face #sculpt #instadaily #instapic #instafun #instagram #graphic #scan #xbox360 #autodesk