One of mine #scientific #illustration from a #paper published on #EpilepsyResearch in 2016 (doi: 10.1016/j.eplepsyres.2016.02.005.). This #simple and #schematic #figure shows a proposed #mechanism for CB-TRPV1 cross-talk in the #MDA. #Neurotransmitter (NT) release is modulated by #presynaptic CBr activation. The different #excitability levels of #DG #neurons could be influenced by: post-synaptic CBr eliciting #inhibitory pathways; #TRPV1, responsible for #cation currents; possible impairment of #CB #system on TRPV1 function. (A), (B), (C), (D): continue arrows indicate the #direct activation of receptors; the barred lines stand for #antagonism or #blockade of a process; dashed arrows show a modulatory action and spotted arrows of different thickness indicate TRPV1-cation currents of different #intensity. Made with #ChembioDraw and #AdobePhotoshop #Science #Neuroscience #medical #biology @thebrainlab @unipait @biology_se @we_love_biology @biology_is_life
















