just another oddity

Uber is a fucking shell game of a company designed to leech investor capital and output bootleg cabs.

Nvidia posted a profit in 2023 of $4.37 billion. This is like someone stealing less than a penny from me.

And they lock this kid in a prison hospital for LIFE?

AI industry groups are urging an appeals court to block what they say is the largest copyright class action ever certified. They’ve warned that a single lawsuit raised by three authors over Anthropic’s AI training now threatens to “financially ruin” the entire AI industry if up to 7 million claimants end up joining the litigation and forcing a settlement.

Authors have until March 30th, 2026 (That is just 9 days as of this reblog, which I am posting on March 21st, 2026) to file their claim against Anthropic to be reimbursed up to $3,000 per work found in the list.

@velvetdemon I'm doing a full reply because I want to give this question the time and space it deserves, and I really do appreciate your curiosity about this.

The short answer: It is deeply unethical. There are nowhere near enough willing patients in the world to be able to do this, and it would be criminal to put them through this.

The long answer: The one side of the equation you're focusing on is: how much of a drug is too much, to the point where it will cause negative side effects or even death? And this is crucial to know. But it's not just a matter of finding out the lethal dosage of a heart cholesterol medication, you need to know that it can actually lower the cholesterol of any living thing. There is no way to know this without giving it first to...a living thing.

But beyond this, I need to emphasize: The goal of a drug trial is to effectively cure people who are already suffering from disease, who are living on limited time.

Drug trials don't just happen on any member of the public, they need to happen specifically on people affected by the disease you're trying to treat. There is at any time a very limited and very marginalized population of the world affected by early onset, familial Parkinson's disease. Because you cannot ethically induce disease in a human being, you are working with, speaking with, and helping patients and their families who are hopeful and desperate for a cure.

If you were to jump straight to human trials from petri dishes, not knowing absolutely anything about how the drug functions in a living, breathing animal body, it would look like this:

We didn't know that minute quantities of the drug interact lethally with x, y, z medication that people are commonly also taking. X number of patients have died as a result.

We didn't know that the drug is fatal to people with [common variant] in their genetics. X more patients have died.

We didn't know the drug exacerbates x, y, z chronic illnesses. X number of people have acquired permanent, lifelong disabilities.

We didn't know the best way to deliver the drug, so we tried multiple ways: the people who received it intravenously are now suffering from a painful, costly, and debilitating condition that did not happen with the ingested form.

I could go on, and on, and on.

The vast majority of these problems can be nearly or almost entirely averted by testing other animals first.

These are all people who possibly could have waited for the normal progression from animal testing to human testing and thus received better outcomes. Some people will pass away in the time it takes to get to that point, and that's heartbreaking, and we all wish science could be faster.

animal research is not the mad scientist wild west that PETA wants you to think it is. there are extremely strict federal laws in place to protect the well being of these animals. animal welfare organizations like AAALAC ensure that lab animals are treated with dignity & respect and are given enough specialized care & enrichment to be happy and content in captivity, just like AZA accreditation with zoos.

not a single animal from a zebrafish to a mouse to a dog to a macaque goes unaccounted for. if an animal gets moved to a new cage, paired for breeding, has a procedure performed on it, gives birth, gets sick or injured, dies, etc. it is legally required that this information is recorded and kept on file for the US federal government to access. failing to record & retain this information is very much punishable by US federal law.

let me tell you - if you abuse or kill an animal, even a mouse - you are almost certainly getting both fired & blacklisted from the industry. if you abuse or kill a more ‘advanced’ animal, such as a dog or monkey, you will likely face criminal charges. killing a monkey is as serious and disastrous as a nuclear meltdown. you are expected to reasonably explain every illness, injury, or death of an animal under your care. you must record all of this information. animals that are clearly suffering with low QOL are required to be euthanized according to AVMA guidelines.

research animals are highly expensive. yes, even the "lesser" animals like mice. the cheapest mice will run you a few hundred $ per individual, with some of the most expensive mice i've cared for being $25,000 per individual. in research we have the "three Rs" - reduction (reduce amount of necessary animals to a minimum), refinement (refine processes to ensure research is accurate and animals feel no pain or distress), and replacement (replace animals with non-living research models as they become available). i can assure you no proper research team is wasting animals (*do not* say "b-b-but elon musk--" his research team is actively being investigated for animal abuse by the government).

research methods that do not require live animals are currently being looked into & efforts spearheaded by - you guessed it - the animal research industry itself (notice how the animal rights people are strangely silent & unhelpful when it comes to this?) but current technology is rudimentary and does not compare to live animal models.

some research animal fun facts (US edition):

all species of animals are only allowed to have one single major surgery performed on them in their entire lifetime.

institutions with nonhuman primates must have a behavior program in place (run by knowledgeable primate specialists) to ensure that they are happy and receiving enough daily enrichment and social interaction.

institutions with dogs are required to have physical exercise programs in place. this means every individual dog gets a substantial amount of leashed AND free-roaming exercise daily, including playgroups with other dogs.

a majority of nonhuman primates get to retire to sanctuaries like peaceable primate sanctuary, and almost all dogs get retired and adopted out by organizations like homes for animal heroes. some institutions will also adopt out unneeded young rabbits, guinea pigs, rats, etc.

some strains of mice glow neon green (or orange or blue) under UV light. this is not harmful to them and is commonly seen in cancer research.

by Keith Humphreys - May 5, 2014           

When I met my fiance’s African-American stepfather, things did not start well. Stumbling for some way to start a conversation with a man whose life was unlike mine in almost every respect, I asked “So, what do you do for a living?”.

He looked down at his shoes and said quietly “Well, I’m unemployed”.

At the time I cringed inwardly and recognized that I had committed a terrible social gaffe which seemed to scream “Hey prospective in-law, since I am probably going to be a member of your family real soon, I thought I would let you know up front that I am a completely insensitive jackass”. But I felt even worse years later when I came to appreciate the racial dimension of how I had humiliated my stepfather-in-law to be.

For that painful but necessary bit of knowledge I owe a white friend who throughout her childhood attended Chicago schools in a majority Black district. She passed along a marvelous book that helped her make sense of her own inter-racial experiences. It was Kochman’s Black and White Styles in Conflict, and it had a lasting effect on me. One of the many things I learned from this anthropological treasure trove of a book is how race affects the personal questions we feel entitled to ask and the answers we receive in response.

My question to my stepfather was at the level of content a simple conversation starter (albeit a completely failed one). But at the level of process, it was an expression of power. Kochman’s book sensitized me to middle class whites’ tendency to ask personal questions without first considering whether they have a right to know the personal details of someone else’s life. When we ask someone what they do for a living for example, we are also asking for at least partial information on their income, their status in the class hierarchy and their perceived importance in the world. Unbidden, that question can be quite an invasion. The presumption that one is entitled to such information is rarely made explicit, but that doesn’t prevent it from forcing other people to make a painful choice: Disclose something they want to keep secret or flatly refuse to answer (which oddly enough usually makes them, rather than the questioner, look rude).

Kochman’s book taught me a new word, which describes an indirect conversational technique he studied in urban Black communities: “signifying”. He gives the example (as I recall it, 25 years on) of a marriage-minded black woman who is dating a man who pays for everything on their very nice dates. She wonders if he has a good job. But instead of grilling him with “So what do you do for a living?”, she signifies “Whatever oil well you own, I hope it keeps pumping!”.

Her signifying in this way is a sensitive, respectful method to raise the issue she wants to know about because unlike my entitled direct question it keeps the control under the person whose personal information is of interest. Her comment could be reasonably responded to by her date as a funny joke, a bit of flirtation, or a wish for good luck. But of course it also shows that if the man freely chooses to reveal something like “Things look good for me financially: I’m a certified public accountant at a big, stable firm”, he can do so and know she will be interested.

Since reading Kochman’s book, I have never again directly asked anyone what they do for a living. Instead my line is “So how do you spend your time?”. Some people (particularly middle class white people) choose to answer that question in the bog standard way by describing their job. But other people choose to tell me about the compelling novel they are reading, what they enjoy about being a parent, the medical treatment they are getting for their bad back, whatever. Any of those answers flow just as smoothly from the signification in a way they wouldn’t from a direct question about their vocation.

when I was younger, I got food poisoning. I was supposed to recover from it, but I wound up with a bunch of nasty medical conditions instead. I never imagined I would become disabled from food.

so I am really glad I have been able to help spread the word every now and then about food safety and recalls, since it hopefully means a few less people going through what I have.

while I have your attention, I do not post every recall, even just for the US, so here are a few of the links I use!

recalls.gov/recent.html <- aggregate of official government recall links for the US! food, drugs, products, child safety seats, motor vehicles, and tires! (half the feeds are broken half the time, but hey, it works™! check the FDA enforcement reports for a more complete list of recalls, especially drug recalls!)

recalls for canada <- recalls for canada!

RASFF <- food recalls and safety alerts for the EU!

food safety news <- news about food safety in the US, canada, and around the world!

I was poisoned <- see where people have gotten food poisoning near you, and report your own! (worldwide!)

me as a froglet: Im kinda seeing the appeal of land tho 👀