I THINK DOGS SHOULD VOTE

a short comic about witches and wishes and wanting things.

graffiti wall more like gay sex wall . i love people sometimes 💛

Full Transcript at the link; 3-minute listen.

Quote:

By taking biopsies from long COVID patients before and after exercising, scientists in the Netherlands constructed a startling picture of widespread abnormalities in muscle tissue that may explain this severe reaction to physical activity.

Among the most striking findings were clear signs that the cellular power plants, the mitochondria, are compromised and the tissue starved for energy.

"We saw this immediately and it's very profound," says Braeden Charlton, one of the study's authors at Vrije University in Amsterdam.

The tissue samples from long COVID patients also revealed severe muscle damage, a disturbed immune response, and a buildup of microclots.

This article mentions that ME/CFS is a "similar complex condition" but that's DEEPLY underreporting the similarities. The phrase "post exertional malaise" (now researchers are trying to replace it but this article uses that phrase) was INVENTED for ME/CFS. It's the only known condition, before "long covid", that causes these kinds of symptoms after exertion!

It's good to know for sure that it's the same mechanisms at play when the inciting viral infection is Covid and not, for instance, Epstein-Barr or RSV, but half the time it doesn't seem like researchers are making comparisons at all, just reinventing the wheel and acting like "long covid" is a totally new phenomenon with no previous point of comparison. There are literally drugs in human trials to try to treat the mitochondrial dysfunction in ME, this dysfunction is well-established and fairly well understood and I feel insane when ppl report on long covid without mentioning that there is already a named and studied condition that accounts for this subset of symptoms!!

SOME researchers are drawing comparisons but they're largely ME researchers who everyone else is largely cignoring because of the widespread perception that ME is a fake disease for lazy women.

That same perception btw is why "graded exercise therapy" (GET), or exercise gradually increasing in intensity, cwas for years the go-to treatment despite MOUNTAINS of evidence that it makes ME patients sicker. Some end up permanently bedbound and unable to even eat or drink without a feeding tube/IV because the damage is so bad! The GET recommendation was finally changed only in the past few years in the US and the UK, and many doctors hate that they're not allowed to recommend it anymore, because they insist despite the evidence that ME/CFS is psychological and ME patients are just "deconditioned" and too lazy to do anything about it.

Now the same kind of "treatment" is being recommended for long covid patients despite evidence showing exercise is having the same kinds of cellular effects as it does in ME patients. "Taking PEM into account" sounds gentler but I'm deeply concerned about the reinvention of GET for patients who meet all the criteria for an illness that's been shown definitively to become permanently worse with GET. This mitochondrial damage is progressive in ME, and there's no reason to believe patients who meet all the criteria of ME after Covid won't experience the same progression if they force themselves past their energy envelope in such a systematic way.

The additional finding that T cells — part of the immune system's arsenal — had infiltrated the muscles of long COVID patients also caught Iwasaki's attention, possibly indicating "an autoimmune response within the muscle cells."

When I was in a reasonably-sized polycule we had actual discussions about it, like “I want to be the tank, you’re obviously the healer, do you think she’d be better at DPS or as support?”

I really just have to summarize Thomas's entire life:

He was in a committed relationship with a male swan named Henry for 18-24 years before a female swan named Henrietta showed up and mated with Henry.

Thomas was initially jealous of the pair and attacked them, breaking 2 of the 5 eggs Henrietta had laid. However, once the remaining eggs hatched, Thomas warmed up to them and helped raise them.

Henry couldn't fly because of an injured wing, so Thomas taught the cygnets how to fly.

When they needed to reduce the goose population in the pond where Thomas and the swans lived, they dyed Thomas's feathers red so he wouldn't be separated from Henry.

Henry, Henrietta, and Thomas remained in their happy throuple for years and raised 68 cygnets before Henry died in 2009. After Henry's death, Henrietta found another swan and flew away, leaving Thomas alone.

Thomas finally met and mated with a female goose in 2011 and had his own babies. However, another goose named George stole them and raised them himself.

As Thomas grew elderly and blind, he was relocated to a wildlife center where he raised orphaned cygnets.

His caretaker at the center described him as "pretty high maintenance."

Thomas died in 2018 at the age of around 40. He had a funeral that included a small coffin and a procession that was led by a bagpiper. He was buried under the stone where Henry was buried, the two finally reunited in death.

"The doctor said I really need to gain weight so I went to the gym to work out really hard and almost fainted and died it's so hard I don't get how people do it ;___; I consume the same amount of calories per day as a newborn baby and have no intention to change that because I start feeling weird (describes the classic symptoms of refeeding syndrome) if I eat more than normal."

"I inhale as much food as 15 men five times my weight who do 16-hour days hauling oil rigs through solid land by dragging them on ropes and in a prehistoric era the clan would have stoned me to death out of fear that I'm possessed by some famine demon. If you tell me to eat more I will fucking eat you too."

The request is so urgent my boss needs it by the end of the work week. Which, y'know, is 5 PM on a Friday. So I have four hours to do it.

It's a forwarded request. Somebody contacted a member of the donation team asking for help, "I need a map from the Vietnam War to use for a presentation." It's somebody she's trying to coax into giving a five figure donation to the museum.

The request was asked to the donation team member, who then emailed my boss, who then emailed and called me urgently.

This map required:

North and South Vietnam in it

All four areas that South Vietnam was divided into for military purposes ('Corps') clearly delineated

Four cities, all of them horrifically misspelled, and only identifiable because I know what battle the requester is asking about (it’s in III Corps on the border with Cambodia) (the requester danced around the battle but I’m knowledgeable enough to identify it)

Has Laos and Cambodia in it

Has the Ho Chi Minh Trail in it

So. I was mad about the 'you have literally four hours to find a map with a lot of requirements.'

I was then mad at myself about finding a copyright free map from Texas Tech University within half an hour, proving her right for asking me to do it.

Then, after I found a map that perfectly met the requirements, I was equally amazed, baffled, and horrified when I read further into the forwarded email chain.

The donation team team member they were speaking to used AI to generate a map.

The above put half of North Vietnam in South Vietnam, made the Ho Chi Minh Trail a country, made 60% of Cambodia part of South Vietnam, put the DMZ extremely high up in North Vietnam, completely disconnected the southern tip of Vietnam, misplaced all of the Corps zones, etc etc

At the very last second the donation team member had a moment of divine clarity, remembering there's three historians on payroll to ask for this kind of thing from. So she contacted my boss while saying, "I had fun with this, but I decided I should check for accuracy before I send it to the donor! I need a fact check by the end of the day, then I send it"

My boss, while not the most knowledgeable on the Vietnam War, does know her geography. She took one look, and knew it was so off she called me to tell me how urgent it is that I look at the email and respond