#multiplesclerosis

This is a great video it explains what many people think about MS, and they are wrong.

I've been asked to stay away from some people because they think multiple sclerosis was contagious.

I've also been told that I can't have multiple sclerosis since I'm not in a wheelchair.

Knowing you are trying your best to balance all that's thrown your way and believing you have some answers and understanding how to deal with symptoms you are having is hard to celebrate victory when there's always a slew waiting to test you over and over.

Neurodegenerative diseases like Alzheimer’s, Parkinson’s, Huntington’s disease, and ALS are some of the most heartbreaking conditions out there. They slowly rob people of memory, movement, and independence. What makes them even harder to fight is that, by the time symptoms appear, the damage in the brain has already begun years earlier.

Click Here to Access Full Article

So how do we catch these diseases before it’s too late? That’s the question we explored in our new review article published in Neurological Sciences:

👉 “MicroRNAs in neurodegenerative diseases: from molecular mechanisms to clinical biomarkers, detection methods and therapeutic strategies — advances and challenges.” 🔗 https://doi.org/10.1007/s10072-025-08419-w

🧠 What Are microRNAs (miRNAs)?

Think of microRNAs as tiny molecular switches 🧩 short RNA strands (about 22 nucleotides long) that help cells decide which genes to turn on or off. They’re incredibly powerful: a single miRNA can regulate hundreds of genes involved in neuron health, inflammation, and stress responses.

When these miRNAs get out of balance, they can drive the processes that lead to neurodegeneration.

🧪 What Our Review Found

Our article dives into how miRNAs are being used in three major ways:

1️⃣ As Biomarkers: Because miRNAs circulate in blood and cerebrospinal fluid, they could make early detection as simple as a blood test instead of invasive brain scans.

2️⃣ For Detection Technologies: We highlight cutting-edge tools like RT-qPCR, NGS, and biosensor platforms, showing how close they are to point-of-care diagnostics 🧫💡.

3️⃣ As Therapeutics: Scientists are now designing miRNA mimics and inhibitors that can correct abnormal gene activity — like silencing harmful proteins in Alzheimer’s or Parkinson’s disease. The biggest hurdle? Delivering them safely across the blood–brain barrier 🧱.

🚀 Why It Matters

MicroRNAs could be the missing link between molecular biology and real-world medicine. If validated, miRNA-based tests could: ✅ Detect neurodegenerative diseases years before symptoms appear ✅ Monitor disease progression non-invasively ✅ Open the door to personalized RNA-based therapies

But for that to happen, we need better standardization, larger patient studies, and smarter data analysis

💬 Final Thoughts

Science is moving faster than ever. What excites me most is how tiny molecules like microRNAs are helping us see the brain’s molecular “whispers” long before it screams for help.

If you’re a neuroscientist, molecular biologist, or just curious about the future of medicine, check out our full paper here 👇

Azam H.M.H. et al. MicroRNAs in neurodegenerative diseases: from molecular mechanisms to clinical biomarkers, detection methods and therapeutic strategies—advances and challenges. Neurological Sciences (2025). DOI: 10.1007/s10072-025-08419-w

2. Azam HMH, Rößling RI, Geithe C, Khan MM, Dinter F, Hanack K, Prüß H, Husse B, Roggenbuck D, Schierack P, Rödiger S. MicroRNA biomarkers as next-generation diagnostic tools for neurodegenerative diseases: a comprehensive review. Front Mol Neurosci (2024). DOI: 10.3389/fnmol.2024.1386735

#OnThisDay Friday, November 14th, 1997

(From left to right) China Chow, Gwen Stefani, Kidada Jones, Aaliyah, and Rashida Jones attending the 5th Annual Race to Erase MS Gala & Fashion Show at the Century Plaza Hotel, Los Angeles, CA.

Race to Erase MS ( @racetoerasems ) is a non-profit organization dedicated to the treatment and ultimate cure of Multiple Sclerosis.

I worked out. And I had a cold shower. And a smoothie.

And I felt better.

And I went to work and did all the things.

I’m motivated to keep going. Moving forward.

A few sclerosis

Too many sclerosis

Just a couple sclerosis

Oops! All sclerosis

An ass load of sclerosis

A dubious amount of sclerosis

Overprikkeling is als een storm die in je hoofd woedt. Geluiden komen te hard binnen, als een tsunami van decibellen die je overspoelt en je doet verdrinken in een zee van ruis. Licht is teveel, als een zon die te fel schijnt en je verblindt, waardoor je je ogen moet sluiten en je jezelf moet terugtrekken in de schaduw.

Gesprekken volg je niet meer, als een radiosignaal dat verstoord wordt door interferentie, waardoor de woorden in je hoofd verdwijnen en je verloren loopt in een doolhof van gedachten. Hersenmist, als een dikke nevel die je hersenen bedekt en je verward maakt, waardoor je niet meer weet waar je bent en wat er om je heen gebeurt.

Overprikkeling kan je heel ziek maken, als een virus dat zich in je lichaam nestelt en je helemaal overneemt. Het kan je alleen laten voelen, als een verlaten eiland waar niemand je kan bereiken en je vastzit in je eigen gedachten. Maar vooral kan overprikkeling je onbegrepen laten voelen, als een vreemdeling in een wereld die te snel, te luid en te fel voor je is. Het is als een schreeuw om hulp die niet gehoord wordt, als een stil verdriet dat verborgen blijft.