Randomness and Fandomness

I just thought you'd like to know :D

Full Transcript at the link; 3-minute listen.

Quote:

By taking biopsies from long COVID patients before and after exercising, scientists in the Netherlands constructed a startling picture of widespread abnormalities in muscle tissue that may explain this severe reaction to physical activity.

Among the most striking findings were clear signs that the cellular power plants, the mitochondria, are compromised and the tissue starved for energy.

"We saw this immediately and it's very profound," says Braeden Charlton, one of the study's authors at Vrije University in Amsterdam.

The tissue samples from long COVID patients also revealed severe muscle damage, a disturbed immune response, and a buildup of microclots.

This article mentions that ME/CFS is a "similar complex condition" but that's DEEPLY underreporting the similarities. The phrase "post exertional malaise" (now researchers are trying to replace it but this article uses that phrase) was INVENTED for ME/CFS. It's the only known condition, before "long covid", that causes these kinds of symptoms after exertion!

It's good to know for sure that it's the same mechanisms at play when the inciting viral infection is Covid and not, for instance, Epstein-Barr or RSV, but half the time it doesn't seem like researchers are making comparisons at all, just reinventing the wheel and acting like "long covid" is a totally new phenomenon with no previous point of comparison. There are literally drugs in human trials to try to treat the mitochondrial dysfunction in ME, this dysfunction is well-established and fairly well understood and I feel insane when ppl report on long covid without mentioning that there is already a named and studied condition that accounts for this subset of symptoms!!

SOME researchers are drawing comparisons but they're largely ME researchers who everyone else is largely cignoring because of the widespread perception that ME is a fake disease for lazy women.

That same perception btw is why "graded exercise therapy" (GET), or exercise gradually increasing in intensity, cwas for years the go-to treatment despite MOUNTAINS of evidence that it makes ME patients sicker. Some end up permanently bedbound and unable to even eat or drink without a feeding tube/IV because the damage is so bad! The GET recommendation was finally changed only in the past few years in the US and the UK, and many doctors hate that they're not allowed to recommend it anymore, because they insist despite the evidence that ME/CFS is psychological and ME patients are just "deconditioned" and too lazy to do anything about it.

Now the same kind of "treatment" is being recommended for long covid patients despite evidence showing exercise is having the same kinds of cellular effects as it does in ME patients. "Taking PEM into account" sounds gentler but I'm deeply concerned about the reinvention of GET for patients who meet all the criteria for an illness that's been shown definitively to become permanently worse with GET. This mitochondrial damage is progressive in ME, and there's no reason to believe patients who meet all the criteria of ME after Covid won't experience the same progression if they force themselves past their energy envelope in such a systematic way.

The additional finding that T cells — part of the immune system's arsenal — had infiltrated the muscles of long COVID patients also caught Iwasaki's attention, possibly indicating "an autoimmune response within the muscle cells."

Nope. And one of the things that made my doctors wave off the possibility of a diagnosis was "well, you don't stim or have trouble socializing or have sensory issues so you're probably just depressed and anxious."

Don't even try signing up for Artfight if you're Jewish. I posted something totally unpolitical on their Discord where I got the star in my handle and promptly got banned for genocide denial. I didn't post anything political on that server, my Art Fight profile, and nothing "discriminatory or hateful" anywhere else.

I just want to catch spelling errors and accidental double spaces and repeated phrases and whenever I use the wrong too/to or affect/effect and shit. But no. They've shoved AI up the ass of every grammar checking software out there and now they all fucking suck and make the most random, obnoxious, nonsensical suggestions.

I get why people keep saying this (and other versions of it like "Use Adobe alternatives" and "Use Google product alternatives."). But here's the problem: I do not create in isolation. Even my own 100% personal projects are getting sent to other people whether it's editors or printers or beta readers and unless every single person in that train is using the same products, things can get wonky.

Libre Office and Word handle formatting differently on the back end, which can completely break documents if you move them back and forth between the two. So if I write in Libre Office but my beta readers are still using Word, when I send them a manuscript for review there's a good chance things won't look right and my beta reader will not actually be reviewing what I sent them.

:| :| :|

They are, I am certain, intentionally programmed that way because the user is supposed to see “errors” coming up every time they write anything and conclude that they Need the AI. That they CAN’T write without the AI. “Look how many things it fixed — I made so many mistakes — I never would have caught all this without the AI.” So they keep using it, because otherwise all their documents will be full of “errors” that they or their human proofreaders all “missed”.

I do a live “fuck Grammarly” demo near the beginning of each semester, where I give it a paragraph from a published work and point out all the mistakes it claims are there, very few if any of which are genuine mistakes of any kind. It also displays that “grammarly score”, which tends to be aggressively low, especially if the text is at all interesting or original — “let’s see what it thinks of some of the stuff you were assigned in high school English as examples of Great Works… ooh, Edgar Allan Poe gets a C, he should learn how to write.”

And, of course, any time you tell it to rewrite something, it can’t come back with “this is already good actually, you don’t need a subscription to Grammarly at all” — if given a text that is already perfectly fine, it will just randomly swap out various words for synonyms. Because it always has to Do Something. If the program makes no changes, you might decide you don’t need it. But if you’re not a confident writer, if Grammarly tells you this synonym is “better”, you’re likely to believe it.

Me: wait