Hello World

another comic about friendship

For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again tomorrow.

That routine just changed.

On March 26, 2026, the U.S. Food and Drug Administration approved Awiqli (insulin icodec-abae), developed by Novo Nordisk, as the first and only once-weekly basal insulin ever approved for adults with type 2 diabetes in the United States.

This is not a minor update to an existing drug.

It is the first entirely new class of basal insulin to reach U.S. patients in more than two decades.

Instead of injecting insulin every single day, people with type 2 diabetes using Awiqli will only need one shot per week, on the same day, every week.

That means reducing from 365 injections a year down to just 52.

For anyone who has ever felt the weight of that daily ritual — the anxiety of forgetting, the physical discomfort, the constant reminder that their body needs help — this approval represents something much bigger than a dosing schedule.

It represents relief.

How the Drug Actually Works

Understanding why this injection lasts a full week requires a quick look inside the body.

Most traditional basal insulins are absorbed into the bloodstream and begin breaking down within 24 hours, which is why patients need a fresh dose every day to maintain stable blood sugar levels.

Awiqli works differently.

Its active ingredient, insulin icodec-abae, is engineered to loosely attach to a blood protein called albumin, which is found naturally and abundantly in the bloodstream.

This attachment creates a slow-release reservoir.

Instead of flooding the system and fading fast, the insulin releases gradually and consistently over an entire seven-day period, keeping blood sugar in a healthy range around the clock...

The FDA reviewed and ultimately declined to approve it for people with type 1 diabetes, citing concerns about a modestly increased risk of hypoglycemia in that population specifically.

Some regulatory agencies in other countries, including the European Union, Canada, Australia, and Japan, have approved Awiqli for both type 1 and type 2 diabetes, but for now the U.S. approval is limited to type 2...

What Comes Next

Awiqli is not standing alone in this space for long.

Eli Lilly is developing its own once-weekly basal insulin, called efsitora alfa, which is currently in late-stage clinical trials.

If that drug also earns FDA approval, it would give patients and doctors two once-weekly options to choose from, allowing for personalized decisions based on a patient’s health profile, insurance coverage, and individual response.

The broader direction of travel in diabetes care is unmistakable.

Fewer injections, smarter formulations, and better integration with digital tools like continuous glucose monitors and insulin-tracking apps are all converging toward a future where managing diabetes requires less daily mental effort without becoming any less medically precise...

A Small Shot With Large Implications

It is easy to look at a once-weekly injection and see only a scheduling change.

But the science behind Awiqli, the scale of the ONWARDS trials, and the consistent satisfaction reported by patients all point toward something that matters far more than convenience.

Diabetes management has always asked a lot of people.

It asks for daily vigilance, daily discipline, and a daily willingness to confront one’s own condition, sometimes in uncomfortable or inconvenient circumstances.

Anything that reduces that load, without reducing the quality of care, is worth taking seriously.

For the more than 37 million Americans living with diabetes, and the hundreds of millions more around the world, a simpler weekly routine could mean the difference between a treatment plan that works on paper and one that actually works in a person’s life.

That is the real significance of what the FDA approved on March 26, 2026.

Not just a new drug.

A new way of keeping people healthy, one week at a time.

Artist: Tim Brierley

tou-san said “boy, you’d better werk”. anyway, please watch kinou nani tabeta

like, possibly with the sense that using the call bell is rude/demanding?

the other thing is that a lot of times when i come in your room, i’m actually doing med pass for all of my patients

generally i have about two hours to pass all my meds. i work somewhere with a pretty good patient-to-nurse ratio. i have 24 minutes per patient every med pass. for many nurses at average hospitals this will be 20 minutes or less.

but that includes everything, from pulling your meds to clarifying orders with docs to actually scanning and giving the meds to doing my required physical assessment etc. possibly hunting down another nurse for a co-sign or narcotic waste.

and if you wait for me to show up, then it also includes basic care tasks, too

i do not think i’m above doing “CNA work.” if you need something please tell me!

but! my floor has aides to assist the nurses with basic patient care for this reason. if you ring, they’re likely to be the first people to respond (because i might have just walked into another patient’s room, and my 24 minute timer for them started counting down already!)

the aides are unlikely to just pop into your room on a regular basis, though. so using your call bell lets us make sure that your needs are met, but it also makes it possible to delegate some of those tasks to the staff members who arent working against a clock

managing the predictable outcomes of administrators intentionally understaffing their hospitals should never be a responsibility that falls on a fucking patient!!!!!

you are sick. you are at the place for helping sick people. we should minimally have the resources and staff to meet your basic needs

[Video of venerable TV naturalist David Attenborough standing amid vegetation.  On a near-horizontal branch above his head is a brown and yellow greater bird of paradise, about the size of a crow, with big floaty yellow plumage puffing out along its back.]

Bird:  Pwuk.  Pwuk. Venerable TV naturalist David Attenborough:  This, surely – Bird (hopping along the branch):  WUKWUKWUkwukwukwukoooh.  Oooh.  Oooh.

[Cut.  Same shot.]

Venerable TV naturalist David Attenborough:  This, surely, is one – Bird:  Kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark kark. Venerable TV naturalist David Attenborough:  This, surely –

[Cut.  Same shot but the bird is on the other side now and venerable TV naturalist David Attenborough has his hand on the branch.]

Bird (hopping up and down on venerable TV naturalist David Attenborough’s fingers):  Eh-eh.  Eh-eh.  Eh-urrrr.  Eh-urrrr. Venerable TV naturalist David Attenborough:  Close up – Bird (hopping away from him):  Tiktiktiktik.  Tiktiktiktik. Venerable TV naturalist David Attenborough:  – the plumes – Bird (hopping around):  Huek. Venerable TV naturalist David Attenborough: – are truly – Bird:  Huek. Venerable TV naturalist David Attenborough:  – exquisite. Bird:  Huek.  Eh-eh. Venerable TV naturalist David Attenborough:  The gauzy – Bird (hopping and spinning on the spot):  HukWUKWUKWukwukoooh.  Oooh. Venerable TV naturalist David Attenborough:  …

[Cut.  Same shot but the bird is back on the original side of the branch.]

Bird:  Aark. Venerable TV naturalist David Attenborough:  Of course, by the eighteenth century – Bird:  Ehhh. Venerable TV naturalist David Attenborough:  – naturalists realized that birds of paradise – Bird (hops across to the other side of the branch) Venerable TV naturalist David Attenborough:  – did have – Bird (hopping back again):  Krrrrrrrrrrrrrrrr. Venerable TV naturalist David Attenborough:  – legs.  Even so – Bird:  WUKWUKWUKWukwukwukooh.

[Cut.  Same shot.] Venerable TV naturalist David Attenborough (apparently trying to tickle the bird’s tummy):  – by about the eighteenth century – Bird (hops away and spins round) Venerable TV naturalist David Attenborough:  – and so – Bird:  AAAAAK AAAK AAAK AAAK AAAK AAAK AAAK AAAK AAAK AAAK AAAK aaak. Venerable TV naturalist David Attenborough (wearily):  …  Very well.

[Cut.  Same shot.]

Venerable TV naturalist David Attenborough:  – but Karl Linnaeus, the great – Bird (vibrating rapidly on the spot and then flapping its wings):  PWAAAAAAAK. Venerable TV naturalist David Attenborough:  – classifier of the natural world – Bird:  AAAAAUUUH AAAUUUH AAAUUUH AAAUUUH AAAUUUH AAAUUUH AAAUUUH AAUUH. Venerable TV naturalist David Attenborough:  – when he came to allocate a scientific name – Bird:  … Venerable TV naturalist David Attenborough:  – to this bird – Bird:  … Venerable TV naturalist David Attenborough:  – called it – Bird:  Wooo-ooo. Venerable TV naturalist David Attenborough:  – wooo-ooo – Bird (surveys the surroundings with a dignified turn of the head) Venerable TV naturalist David Attenborough:  ‘paradisia apoda’: the bird of paradise – Bird:  Hoooo. Venerable TV naturalist David Attenborough:  – without legs. Bird:  Eh-eh.

[Close-up of the bird.]

Bird:  WUKWUKWUKWUkwukwukwukwukoooh.  Ooh. Bird:  Ooh.