..::WELCOME::..

every fat person you know for the most part probably has a story like this, of medical neglect. many of the stories i've heard personally are when the complaint or the doctor wasn't related at all, like being told to lose weight at the ear nose and throat doctor or at the dentist. it's straight up just bias. it's such a thing that in the show Shrill it's portrayed, when Aidy Bryant goes to the gynecologist and her doctor suggests she get gastric bypass.

the studies on health and fatness are simply not that black and white and there is basically no research that shows that more than an incredibly tiny minority of people can lose weight and keep it off for more than like 2 years. bodies have set points that they gravitate towards, it's not a personal failure. this also is how the weight loss industry succeeds so well - repeat customers.

some of the harm associated with fatness is also due to weight cycling, which is very hard on your body and is even worse if you get off a GLP1, which according to a recent study causes weight to be regained at a rate that is 4x faster than without taking a GLP1.

you don't have to hate yourself. you don't have to hate other people for their body type either. it makes me so sad to see the thinspo tag going around again in 2026 a lot like it was back in the day.

some resources to learn more here:

https://www.reuters.com/article/business/healthcare-pharmaceuticals/feeling-fat-may-be-worse-for-you-than-being-fat-idUSTON079061/

It was taken by a biologist that studies birds so it seems like he knows what he’s doing. For the most part. Here’s his caption:

they get their toxin (batrachotoxin) from beetles they eat. this is the same toxin found in species of poison dart frogs. the toxin does not naturally occur in the birds (nor the frogs). the hooded pitohui is the most poisonous bird we know of.

also, i think this was mentioned elsewhere in this thread, but they aren’t corvids! they’re of the family oriolidae. from birdpartners.org: “Toxicity evolved at least five times in Papuan birds in the superfamily Corvoidea,” and that may be where that idea came from (although the hooded pitohui is not in that superfamily). that’s just where toxicity in birds in papua new guinea came from (if I’m understanding correctly)

there are other birds native to papua new guinea that are also toxic! this includes other species of pitohui, the little shrikethrush, and the blue-capped ifrit. recently, it was discovered that the regent whistler and rufous-naped bellbird are toxic as well. these are birds that we already knew of. they’ve been studied and photographed and all that. the fact that we’ve only recently discovered their toxicity begs the question: how many other species of birds are toxic? most birds aren’t tested for toxicity. there could be tons of toxic birds, yet we don’t know it.

"For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again tomorrow.

That routine just changed.

On March 26, 2026, the U.S. Food and Drug Administration approved Awiqli (insulin icodec-abae), developed by Novo Nordisk, as the first and only once-weekly basal insulin ever approved for adults with type 2 diabetes in the United States.

This is not a minor update to an existing drug.

It is the first entirely new class of basal insulin to reach U.S. patients in more than two decades.

Instead of injecting insulin every single day, people with type 2 diabetes using Awiqli will only need one shot per week, on the same day, every week.

That means reducing from 365 injections a year down to just 52.

For anyone who has ever felt the weight of that daily ritual — the anxiety of forgetting, the physical discomfort, the constant reminder that their body needs help — this approval represents something much bigger than a dosing schedule.

It represents relief.

How the Drug Actually Works

Understanding why this injection lasts a full week requires a quick look inside the body.

Most traditional basal insulins are absorbed into the bloodstream and begin breaking down within 24 hours, which is why patients need a fresh dose every day to maintain stable blood sugar levels.

Awiqli works differently.

Its active ingredient, insulin icodec-abae, is engineered to loosely attach to a blood protein called albumin, which is found naturally and abundantly in the bloodstream.

This attachment creates a slow-release reservoir.

Instead of flooding the system and fading fast, the insulin releases gradually and consistently over an entire seven-day period, keeping blood sugar in a healthy range around the clock...

The FDA reviewed and ultimately declined to approve it for people with type 1 diabetes, citing concerns about a modestly increased risk of hypoglycemia in that population specifically.

Some regulatory agencies in other countries, including the European Union, Canada, Australia, and Japan, have approved Awiqli for both type 1 and type 2 diabetes, but for now the U.S. approval is limited to type 2...

What Comes Next

Awiqli is not standing alone in this space for long.

Eli Lilly is developing its own once-weekly basal insulin, called efsitora alfa, which is currently in late-stage clinical trials.

If that drug also earns FDA approval, it would give patients and doctors two once-weekly options to choose from, allowing for personalized decisions based on a patient’s health profile, insurance coverage, and individual response.

The broader direction of travel in diabetes care is unmistakable.

Fewer injections, smarter formulations, and better integration with digital tools like continuous glucose monitors and insulin-tracking apps are all converging toward a future where managing diabetes requires less daily mental effort without becoming any less medically precise...

A Small Shot With Large Implications

It is easy to look at a once-weekly injection and see only a scheduling change.

But the science behind Awiqli, the scale of the ONWARDS trials, and the consistent satisfaction reported by patients all point toward something that matters far more than convenience.

Diabetes management has always asked a lot of people.

It asks for daily vigilance, daily discipline, and a daily willingness to confront one’s own condition, sometimes in uncomfortable or inconvenient circumstances.

Anything that reduces that load, without reducing the quality of care, is worth taking seriously.

For the more than 37 million Americans living with diabetes, and the hundreds of millions more around the world, a simpler weekly routine could mean the difference between a treatment plan that works on paper and one that actually works in a person’s life.

That is the real significance of what the FDA approved on March 26, 2026.

Not just a new drug.

A new way of keeping people healthy, one week at a time."

She got the idea for the study while walking with her advisor at Stanford to discuss her thesis topic, and the paper she eventually published in the Journal of Experimental Psychology in 2014 is sharp enough that it should have ended the seated meeting on the day it came out.

She ran 4 experiments on 176 people. Same person tested twice. Once sitting, once walking. The creativity tasks were the standard ones psychologists have used for decades to measure how good a brain is at generating novel useful ideas.

81% of participants in the first experiment produced more creative ideas while walking than while sitting. In the second experiment, 88%. In the third, 100%. Every single person walked into a more creative version of themselves. On average, people generated 60% more novel useful ideas the moment their legs started moving.

The skeptical question is the obvious one. Maybe it was the fresh air. Maybe it was the scenery passing by. Maybe it was the change of environment doing the work, not the walking itself.

Oppezzo killed every one of those explanations with one experimental decision. She put people on a treadmill facing a blank wall. No scenery. No fresh air. No environmental change. Just legs moving in place while staring at white drywall. The 60% boost held.

Then she ran the experiment that closed the case completely. She took participants outside in two conditions. Half of them walked through a Stanford courtyard. The other half were pushed through the exact same courtyard in a wheelchair. Same outdoor stimulation. Same scenery passing at the same speed. The only difference was whether the legs were moving.

The walkers produced dramatically more novel high-quality ideas than the wheelchair group. The outdoors did almost nothing on its own. The walking did everything.

She also tested the opposite kind of thinking. Convergent thinking. The kind where there is one right answer and you have to narrow down to it. Word puzzles where 3 words share a hidden fourth word that connects them. The seated participants did slightly better on these. Walkers got slightly worse.

Walking is not a general intelligence enhancer. It does one specific thing. It opens up the divergent search inside your brain. The part that generates options. The part that produces unexpected connections. The part that takes a problem and finds five ways into it instead of one.

When you need to converge on the single right answer, sit down. When you need to find the answer in the first place, get up.

The mechanism is now well understood. Walking selectively activates what neuroscientists call the default mode network, the system inside your brain that runs when you are not consciously focused on anything. The DMN is where mind-wandering happens. Where memories cross-reference each other. Where ideas that have been sitting in separate folders inside your head finally bump into each other.

When you sit at a desk and force yourself to concentrate, you suppress the DMN. When you walk at a natural pace, the executive part of your brain gets just busy enough handling the walking that the DMN comes online and starts doing the work that focus was blocking.

The most useful finding in the entire paper is the one almost nobody quotes. The boost did not turn off the moment people stopped walking. Participants who walked first and then sat back down stayed elevated. Their next round of seated creativity work was still significantly better than people who had been sitting the whole time. The rest lingered for at least several minutes after the legs stopped moving.

You do not need to do creative work while walking. You need to walk before the creative work. The brain holds the state.

On one of these days, he finds a farmhouse of a very jittery couple who agree to let him sleep in the barn, with the conditions that he sleeps in the barn loft and if he's found, they disavow all knowledge that he was there. He agrees, because he's exhausted and will sleep in a hay pile if he has to. My grandpa manages to fit all six foot three inches of himself into a feed trough stored upstairs and tries to get some sleep.

However, right when he's half-snoozing, he hears motors outside and sure enough, here are some very angry officers of mixed Nazi and Vichy make confronting the couple saying someone up the road spotted an American soldier walking this way. They wouldn't know anything about that, would they? No, of course not.

All the while, my grandpa—now trying to figure out how to either escape the barn unseen or how to fight off six? seven? eight? people at once—freezes up and waits for the inevitable. While he does, a HUGE spider crawls next to his head and onto the loft railing. For one second, he thinks about swatting it away, but that would risk him being seen and killed.

So, instead, he lays there and waits to either fight to the death or get executed in a feed trough. And while he lays there, the spider starts making a huge web on the railing. My grandpa's transfixed by this thing. He watches her go around and around, building a solid web before plopping herself off to one side and waiting for breakfast. At the same time, the officers finally go into the barn.

My grandpa can hear them searching around, turning over crates and checking animal pens. Then, he hears one say to check the loft.

And then another say, "Don't bother. Look at the spiderwebs up there. No one's been there in a while."

And they leave.

Because my grandpa didn't swat the spider away and let her build her web, the officers thought no one was there and left him alone. They drive off and my grandpa immediately thanks the farmer couple and hauls ass out of there as soon as he can.