#human physiology

I don’t care about sports. I don’t give a damn about the Olympics for other reasons I won’t talk about. But I’m pissed now.

If we are to disqualify the people from the Olympics, we should be 100% fair. No biological advantages allowed!

2-meter-tall basketball player? No way, that’s unfair.

That gymnast with hyper-mobility? BOO. Unfair.

Usain Bolt with the gene ensuring the composition of his muscles? How dare he?

Believe or not, the professional sport is based on anomalies and mutation. That’s the selection. It sucks and it’s not fair but it is what it is.

Also, having these mutations doesn’t mean you’re automatically great at sports - I’m shit at gymnastics while being hypermobile as fuck. So it’s still unfair even to us expressing these traits, lol.

There are XY AFAB women!!!

This happens during the pregnancy if the child has male chromosomes but there is not enough male hormones in the development of the baby resulting in the baby being assigned female at birth. It’s a form of intersex, but there is literally no physical difference between such child and XX AFAB baby.

Those are cis women. Not trans men. Not even trans men.

The people screaming about the Olympics being a disgrace and the proof of collapse of the society are literally the people who are usually like “there are two genders based on what’s in their pants”. Now it’s the chromosomes you’re checking?

Maybe you are an XY-woman, maybe your sister is. You don’t know.

Lately, I've been noticing some patterns, not only in my life, but in everyone else's. Human relationships aren't long-lasting anymore. By relationships, I mean everything: family, friendships, romantic relationships, everything. "Your mother did something once that unintentionally hurt you? Cut ties." "You love this person, but that one harmless trait people don't like... kinda red flag. Break up." "Oh, that one friend is so annoying sometimes. But you know what? I won't talk to them, I'll just cut them off from my life."

It's fucking glorious.

The little mechanisms inside our intestines, everything that goes into them. I can't help it, but it's humbling. It all sounds so disgusting, but I think our bodies are beautiful things, we ought to marvel at how effectiently we survive. Do you know every little thing that goes into maintaining our homeostasis? The negative feedback that helps us thermoregulate, the positive feedback that makes your blood clot, and that all comes together so that the human body remains stable, and survives.

Greetings, Tumblr community! 🧠💡 Let's engage in a comprehensive exploration of the sodium-potassium pump, dissecting its molecular intricacies and elucidating its critical role in cellular homeostasis.

Introduction:

The sodium-potassium pump, residing within the cellular membrane, is an adenosine triphosphate (ATP)-dependent transmembrane protein pivotal for maintaining ionic balance. Its primary function is to actively transport three sodium ions out of the cell while concurrently importing two potassium ions.

Functional Mechanism:

In terms of mechanistic precision, the sodium-potassium pump operates as an ATPase enzyme, utilizing the energy derived from ATP hydrolysis. This primary active transport process involves sequential conformational changes within the pump's structure.

The process commences with the binding of intracellular sodium ions to high-affinity sites on the pump. Subsequent phosphorylation, facilitated by ATP, induces conformational alterations that render the pump receptive to extracellular potassium ions. This triggers dephosphorylation, allowing potassium ions to be released intracellularly.

This orchestrated ion exchange serves to uphold the electrochemical gradient across the cellular membrane, establishing and preserving the resting membrane potential. In essence, the sodium-potassium pump is the architect of the delicate balance between sodium and potassium concentrations.

Physiological Significance:

The physiological ramifications of this meticulous ion transport extend to neuronal excitability and osmoregulation. By contributing to the establishment of the resting membrane potential, the pump plays a pivotal role in regulating action potentials and facilitating the propagation of nerve impulses.

Additionally, the pump actively participates in cellular volume control through osmoregulation. Its influence on water movement prevents cellular swelling or shrinkage, underscoring its significance in maintaining cellular integrity.

For those seeking empirical validation, consider consulting the following authoritative sources:

1. **Alberts B, Johnson A, Lewis J, et al.** Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002. Section 11.3, The Plasma Membrane.

2. **Nelson DL, Cox MM.** Lehninger Principles of Biochemistry. 7th edition. New York: W.H. Freeman; 2017. Chapter 11, Active Transport and the Cytoskeleton.

3. **Lodish H, Berk A, Zipursky SL, et al.** Molecular Cell Biology. 4th edition. New York: W. H. Freeman; 2000. Section 15.1, The Transport of Small Molecules Across Membranes.

The feeling of lump in the troat when you're about to cry is due to your amygdala(the part of brain that is responsible for emotions) activates your hypothalamus which in turn activates your sympathetic system which causes constriction on the muscles in your troat.

I only answer this because I remain rather astonished that my wife answered this very intimate question herself. Even after over a decade of having these presences, we are still both frequently surprised by what the other is willing to share with the internet.

life lately <3

- visited the science museum with my mom to donate blood, was very disappointed not to see any bacteria exhibits

- finally made a friend in my human physiology lecture!!! she got my number and we did our group quiz together :) she is pre-nursing

- drank for the first time and learned that my anxiety disappears when im tipsy-ish, also pet a stray cat

- had my first human physiology lab, not too sure about my group mates so far... but we'll see!

life is going really well, but i miss a lot of my friends who i dont see as often now.