You’re not alone in this, none of us are.

@velvetdemon I'm doing a full reply because I want to give this question the time and space it deserves, and I really do appreciate your curiosity about this.

The short answer: It is deeply unethical. There are nowhere near enough willing patients in the world to be able to do this, and it would be criminal to put them through this.

The long answer: The one side of the equation you're focusing on is: how much of a drug is too much, to the point where it will cause negative side effects or even death? And this is crucial to know. But it's not just a matter of finding out the lethal dosage of a heart cholesterol medication, you need to know that it can actually lower the cholesterol of any living thing. There is no way to know this without giving it first to...a living thing.

But beyond this, I need to emphasize: The goal of a drug trial is to effectively cure people who are already suffering from disease, who are living on limited time.

Drug trials don't just happen on any member of the public, they need to happen specifically on people affected by the disease you're trying to treat. There is at any time a very limited and very marginalized population of the world affected by early onset, familial Parkinson's disease. Because you cannot ethically induce disease in a human being, you are working with, speaking with, and helping patients and their families who are hopeful and desperate for a cure.

If you were to jump straight to human trials from petri dishes, not knowing absolutely anything about how the drug functions in a living, breathing animal body, it would look like this:

We didn't know that minute quantities of the drug interact lethally with x, y, z medication that people are commonly also taking. X number of patients have died as a result.

We didn't know that the drug is fatal to people with [common variant] in their genetics. X more patients have died.

We didn't know the drug exacerbates x, y, z chronic illnesses. X number of people have acquired permanent, lifelong disabilities.

We didn't know the best way to deliver the drug, so we tried multiple ways: the people who received it intravenously are now suffering from a painful, costly, and debilitating condition that did not happen with the ingested form.

I could go on, and on, and on.

The vast majority of these problems can be nearly or almost entirely averted by testing other animals first.

These are all people who possibly could have waited for the normal progression from animal testing to human testing and thus received better outcomes. Some people will pass away in the time it takes to get to that point, and that's heartbreaking, and we all wish science could be faster.

animal research is not the mad scientist wild west that PETA wants you to think it is. there are extremely strict federal laws in place to protect the well being of these animals. animal welfare organizations like AAALAC ensure that lab animals are treated with dignity & respect and are given enough specialized care & enrichment to be happy and content in captivity, just like AZA accreditation with zoos.

not a single animal from a zebrafish to a mouse to a dog to a macaque goes unaccounted for. if an animal gets moved to a new cage, paired for breeding, has a procedure performed on it, gives birth, gets sick or injured, dies, etc. it is legally required that this information is recorded and kept on file for the US federal government to access. failing to record & retain this information is very much punishable by US federal law.

let me tell you - if you abuse or kill an animal, even a mouse - you are almost certainly getting both fired & blacklisted from the industry. if you abuse or kill a more ‘advanced’ animal, such as a dog or monkey, you will likely face criminal charges. killing a monkey is as serious and disastrous as a nuclear meltdown. you are expected to reasonably explain every illness, injury, or death of an animal under your care. you must record all of this information. animals that are clearly suffering with low QOL are required to be euthanized according to AVMA guidelines.

research animals are highly expensive. yes, even the "lesser" animals like mice. the cheapest mice will run you a few hundred $ per individual, with some of the most expensive mice i've cared for being $25,000 per individual. in research we have the "three Rs" - reduction (reduce amount of necessary animals to a minimum), refinement (refine processes to ensure research is accurate and animals feel no pain or distress), and replacement (replace animals with non-living research models as they become available). i can assure you no proper research team is wasting animals (*do not* say "b-b-but elon musk--" his research team is actively being investigated for animal abuse by the government).

research methods that do not require live animals are currently being looked into & efforts spearheaded by - you guessed it - the animal research industry itself (notice how the animal rights people are strangely silent & unhelpful when it comes to this?) but current technology is rudimentary and does not compare to live animal models.

some research animal fun facts (US edition):

all species of animals are only allowed to have one single major surgery performed on them in their entire lifetime.

institutions with nonhuman primates must have a behavior program in place (run by knowledgeable primate specialists) to ensure that they are happy and receiving enough daily enrichment and social interaction.

institutions with dogs are required to have physical exercise programs in place. this means every individual dog gets a substantial amount of leashed AND free-roaming exercise daily, including playgroups with other dogs.

a majority of nonhuman primates get to retire to sanctuaries like peaceable primate sanctuary, and almost all dogs get retired and adopted out by organizations like homes for animal heroes. some institutions will also adopt out unneeded young rabbits, guinea pigs, rats, etc.

some strains of mice glow neon green (or orange or blue) under UV light. this is not harmful to them and is commonly seen in cancer research.

It's common sense here, except for USians, so I'll analyze it a bit more for the dominant demographic here. In a globalized setting, the most dominant culture affects the others and sets the trends. The way our language works, how we think, our levels of politeness and intimacy, and our levels of respect. (flash news, they are going down 😂)

I don't want to imply that there is nothing good in the US. There are plenty of positives in the country. It's just that for the rest of the cultures online it's a constant daily fight to not forget our roots, with the degree US media and brands have permeated our lives. In Greece at least we watch more US American media than Greek media nowadays, and many of our shows are rip-offs of USian ones, with little adaptation to Greek reality and culture.

And to demonstrate the amount of this exposure, a 22-year-old Greek asked me the other day "if something happens we call 911, right?" This might have literally cost them their life, in a dangerous situation! Because all the movies and songs they consumed (not an unusual thing for the Greek youth) were what they knew. And I found a similar comment in this comment thread.

It's about American media drowning out native language media all over the world, and workplaces requiring the English language in your repertoire more and more. It's about proper translations and foreign language dubbing of films disappearing because "everyone speaks/should speak English anyway." All of this is leading to the deterioration of native speaker groups of languages worldwide.

In my country, Dutch language courses can't find enough people who want to study the language, while English language courses are overflowing with people who want to study the language. There is even widespread distaste for the Dutch language for being crude or sounding rough or what have you. That's our native language!!! That is our culture in its purest form!!! That is knowledge we inherit from our parents as they did from theirs!!! That is how we learned fairytales and folk stories and myths!!! That is the language that shapes our communication and our way of thinking!!! To hate your native language is to hate yourself at the deepest level.

And yet it's so normalised. Droves of foreigners living in the Netherlands will never learn a word of Dutch, because "everyone speaks English anyway." We are the world's leaders in non-native understanding of English, but it comes at a cost. A grave cost we will continue to pay.

If you're looking to support your non-American friends in any way that is not performatively shouting "I hate being an American" into the void, first of all, unlearn that hatred of yourself and your culture. You are of no help self-flagellating, and there is a difference between holding your country accountable for its issues, and denying yourself your culture because your country is doing and has done bad things.

(I am not going to get into arguments about whether or not US American culture exists. It does, and if you think differently you are welcome to change your mind.)

Secondly, learn about other countries. Learn a bit of Chinese. Take an interest in the Italian political system. Ask your friends about their countries' folklore. Watch documentaries about art from Nigeria. Absorb information that is not fed to you by American media.

And thirdly, quit expecting your non-American friends to communicate in a way that appeals to you. The French and Dutch will always seem rude to you because our way of communicating is far more direct than the way you communicate. People from other cultures may seem vague to you because their way of communicating is far more indirect, and you're not used to that either. Quit being frustrated when you don't get what we mean exactly. Quit assuming we mean the absolute worst thing you could imagine just because you didn't get what we meant the first time. Ask us to explain if you need us to, and learn to accept that we are different from you.

Dear Representative [Name],

I am writing to express my strong opposition to H.R. 8250 (The "Parents Decide Act"). As your constituent and a concerned citizen, I believe this bill introduces unprecedented risks to digital privacy and security.

Specifically, I am alarmed by:

SEC. 2(a)(1)(B): Requiring age verification to even use an operating system creates a mandatory "hardware lockout" that ends anonymous computing and forces users to hand over sensitive identification data to major corporations just to power on their devices.

SEC. 2(a)(3): Mandating that OS providers create a system for all app developers to access verification data is a massive security vulnerability. This effectively creates a centralized API of user identities accessible to thousands of third-party developers, many of whom may lack adequate data protection.

This bill does not protect children; it creates a centralized surveillance infrastructure at the OS level. I urge you to protect the privacy of your constituents and vote NO on H.R. 8250.

Sincerely,

[Your Name]

Given that, in the wake of this mandatory identification policy, my country seems to be moving to hand over its citizens biometric data, like fingerprints, Face ID files, and identification documents, over to the USA and to ICE to maintain the visa free travel (ESTA) we have, I strongly urge any US resident to send these emails, or make calls.

But if you can’t do that, the most powerful thing you can do is spread the word. Tell your friends, family, coworkers, anyone who can help.

My reach will likely be small, and so I don’t know if this will mean very much in the grand scheme of things, but I cannot stand to see this tracking happen to another population as it did to mine.

And if you think it won’t affect you, it will. All anonymity goes out the window when your accounts can be linked via your personal ID

And there are so many articles and videos and discussions. Like, the scientific community is buzzing about this.

So much research will have to be redone because the data was absolutely compromised, off by orders of magnitude, by using standard lab gloves.

The world is probably not horrifically contaminated by microplastics. Sterile laboratories, however, are contaminated by latex and nitrile gloves.

Sources beyond dude just trust me, for the skeptics.

https://www.technologynetworks.com/applied-sciences/news/scientists-lab-gloves-may-be-causing-an-overestimation-of-microplastics-411138

Nitrile and latex gloves may cause overestimation of microplastics - Phys.org (it’s a pdf)

Hey! Just a reminder! AO3 does NOT have an app. This garbage was made by theives who steal fan artist’s work and sell it back to you.

“Oh, but it’s free!” There are ads. They are making money off of this. They are stealing from the creators you love and you are hurting those same creators if you use this app or any similar app.

None of the signup methods require a password. It only takes email and birthday. Minimizing time on the signin or signup screen makes it harder for people quitting to avoid relapse.

"Characters" on the website will send messages "on their own" (prompted by the site) to try to invite inactive users back after as soon as 1 day of inactivity. This is likely to force FOMO, or make users feel more like they owe the bots a response. Unhealthy attachment stuff.

Account deletion is an essential part of every service that should go smoothly, right? Right? Wrong. It takes 1-2 weeks for a Character AI account deletion to be finalized, and account deletion requests have a high chance to not go through if you're not using the app.

Rephrasing: People leaving Character.AI are pushed to download the app in order to delete their accounts, if they haven't already. This makes it harder for people to quit and stay gone. Failing to quit an addiction makes it harder to quit successfully in the future, so this feels like a feature, not a bug. On top of that, the delete account menu reads like this: