One of the ways The Murderbot Diaries breaks from sci-fi tradition the most is in how it treats aliens. As in, no one gives a shit.
In pretty much any other sci-fi, in one way or another, aliens are the most important thing to happen to the human race. Encountering aliens might be a near spiritual experience. Just learning that they exist and "we are not alone" is a pivotal moment of great awe (or a moment of great horror and fear that this stellar ocean is much deeper and darker than we thought). Other times aliens represent a reckoning, as we face our own weaknesses and undertake a great battle again the Other (in the literal sense) or against our inner darkness (metaphorically).
In The Murderbot Diaries we totally found aliens! Or at least ruins of alien civilizations... But tell Capt. Picard to put away the flute and the archaeology books- we euphemistically call them "strange synthetics," and instead of revealing deep truths about what it is to be alive, they'll probably just infect you with a bizarre disease that turns you half alien.
Only idiots mess with that stuff. Even in the Corporation Rim where money is king, mining those ruins for their oh-so-tempting advanced technology is a big no-no, practically the only law that corporations (usually) won't break.
Oh yeah, and there are (probably unintelligent, but it's not really investigated) alien creatures just running around on planets. We aren't studying them for their unique biology and learning how to gene hack ourselves or invent new medicine, they're mostly annoyances who try to eat us (see: literally the first thing that happens in the book and TV series).
Even in learning-and-human-betterment-driven Preservation, there's no evidence of alien archaeologists or xeno-whateverists. No evidence of cultists worshipping aliens or trying to contact them. We just have a bunch of people going about their human (and construct (and bot)) business despite, you know, aliens!
Granted, we're seeing all this through Murderbot's perspective, who clearly has, um, other priorities. But I feel like it would have at least mentioned those people as some kind of extra special idiot.
This isn't a criticism, it's just interesting to me, and I realized a part of me kept waiting for someone to care about the aliens. It certainly has historical context- some cultures met and established trade and mutual exchange, while others were, well, like the conquistadors meeting native flora, fauna, and people in new lands... that stuff was mostly in their way. And given that it's "just" ruins, there are certainly many, many cases where we've built whole cities on top of old ones without a second thought for history (yes, the opposite is also true again... Humans are complicated).
So, I guess, thanks for the new perspective