#vortioxetine

I looked this up and WOW. If my escitalopram ever stops helping my depression (it also helps with some of my ADHD crap), I’m going to ask to try vortioxetine. Here’s the study I looked at; the full text is available at that link, free. Basically, it improves executive functioning, processing speed, memory, and other things that are definitely part of ADHD. I will be interested to know if it helps you!

I also looked it up at crazymeds, and they say that you should know if it’s going to work by the end of the second week.

Brand Name: Trintellix

Common Dosage Forms:

Tablets: 5 mg, 10 mg, 20 mg

FDA Indications/Dosages:

For the treatment of major depressive disorder (MDD) in adults: The recommended starting dose is 10 mg given once a day without regard to meals. The recommended maintenance dose is 20 mg/day. Patients who do not tolerate 10 mg/day may be decreased to 5 mg/day.

Monitor: Serum sodium, clinical worsening, suicidality, unusual changes in behavior

Drug Interactions: Vortioxetine’s primary mechanism of action is thought to be inhibition of the reuptake of serotonin (5-HT). It is also an inhibitor of serotonin 5-HT3 and an agonist of serotonin 5-HT1A, both of which may contribute to its action. Peak plasma levels are reached in 7-11 hours after an oral dose and the mean terminal half-life is approximately 66 hours. Steady state plasma levels are reached in about 2 weeks. Metabolism occurs primarily through oxidation via CYP2D6, but other isoenzymes play a role as well.

Pharmacology/Pharmacokinetics: Doses should be decreased by half when coadministered with strong inhibitors of CYP2D6 (bupropion, fluoxetine, paroxetine, or quinidine). Doses may need to be increased when coadministered with strong CYP2D6 inducers (rifampin, carbamazepine, phenytoin). Do not concomitantly or within 21 days of treatment with MONOAMINE OXIDASE INHIBITORS (MAOI). Use with aspirin nonsteroidal anti-inflammatory agents, and warfarin may increase the chance of abnormal bleeding.

Contraindications/Precautions: Use is contraindicated in patients within 21 days of stopping an MAOI used to treat psychiatric disorders. ANTIDEPRESSANTS INCREASE SUICIDAL THOUGHTS AND ACTIONS IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS. Patients being treated with antidepressants should be observed closely for clinical worsening and suicidality, especially at the beginning of therapy, or at the time of dose changes. May activate mania/hypomania in some individuals; use appropriate precautions. Use with caution in patients with a history of controlled narrow-angle glaucoma. Do not use late into the third trimester.

Adverse Effects: The most common adverse effect is transient nausea. Other common adverse effects include diarrhea, dry mouth, dizziness, constipation, vomiting, flatulence, pruritus, and abnormal dreams.

Patient Consultation:

Pay close attention to any changes, especially sudden changes, in mood behaviors, thoughts, or feelings. Antidepressants may increase suicidal thoughts or actions. Continued therapy of up to 2 weeks may be needed to show noticeable improvement.

May be taken without regard to meals.

Consult a physician or pharmacist before taking nonprescription medications, especially aspirin and NSAIDs.

Do not abruptly discontinue medication.

Store in a cool, dry place away from sunlight and children.

Contact a physician if the above side effects are severe or persistent.