#mesalazine

Mesalazine also known as mesalamine, or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease. It is generally used for mildly to moderately severe disease. It is taken by mouth or rectally. The formulations which are taken by mouth appear to be similarly effective.

According to the new market research report “Global Mesalazine Market Report 2023-2029”, published by QYResearch, the global Mesalazine market size is projected to reach USD 0.23 billion by 2029, at a CAGR of 3.1% during the forecast period.

Figure.   Global Mesalazine Market Size (US$ Million), 2018-2029

Figure.   Global Mesalazine Top 15 Players Ranking and Market Share (Ranking is based on the revenue of 2022, continually updated)

The global key manufacturers of Mesalazine include Syntese A/S, PharmaZell, Cambrex Corporation, Divis Laboratories, Chemi SpA, Ipca Laboratories, Hangzhou Brother, Lianyungang Fengheng Biopharm, Lasa Loboratory, Corden Pharma Bergamo, etc. In 2022, the global top five players had a share approximately 71.0% in terms of revenue.

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Mesalazine is an anti-inflammatory agent that acts locally in the gastrointestinal tract to reduce inflammation. Its exact mechanism of action is not fully understood, but it is believed to work by inhibiting the production of inflammatory mediators and modulating the immune response in the intestinal mucosa.

The active pharmaceutical ingredient (API) in mesalazine is, as the name suggests, mesalazine itself.

CAT. No.M010003

CAS. No.1261398-47-3

Mol. F.C13C6H8ClNO3

Mol. Wt.195.55 g/mol

Synonyms: Mesalazine-13C6 Hydrochloride;5-Amino-2-hydroxybenzoic Acid;5-Amino-2-hydroxybenzoic Acid-13C6 Hydrochloride;Fisalamine-13C6 Hydrochloride;(Mesalazine-13C6 Hydrochloride);5-ASA-13C6 Hydrochloride;Mesalamine-13C6 Hydrochloride;Asacol-13C6 Hydrochloride;Asacolitin-13C6 Hydrochloride;Claversal-13C6 Hydrochloride Mesasal-13C6 Hydrochloride;Pentasa-13C6 Hydrochloride

Chemical Name: 5-Amino-2-hydroxybenzoic Acid-13C6 Hydrochloride

Mesalazine, also known as 5-Aminosalicylic acid (5-ASA) or Mesalamine is a well-established drug known for the management of inflammatory bowel disease and it is used for treating Ulcerative colitis (UC) and Crohn’s disease (CD).

Mesalazine is the active component of sulfasalazine, which is commonly administered for the treatment of colitis. Mesalazine is an amphoteric compound and its synthesis involves multi-steps starting with salicylic acid and sodium hydroxide reaction.

Various impurities associated with Mesalazine in the form of intermediates, by-products, metabolites, degradants, etc. are available at Pharmaffiliates.

Pharmaffiliates Analytics and Synthetics P. Ltd. is a global name and a trusted partner for custom synthesis and it offers one of the largest inventories of Certified Impurity Standards.

Pharmaffiliates strives to provide the fastest services for quick product development resulting in cost optimization and hence considered as a reliable and integrated partner by many Pharmaceutical giants for outsourcing their products and services.

Some of the important impurity standards of Mesalazine which are obtainable at Pharmaffiliates are mentioned below:

Mesalazine Impurity P (Product code - PA 13 23160, CAS No.- 887256-40-8), which is chemicallymknown as 5-Amino-2-hydroxy-4'-sulfo-[1,1'-biphenyl]-3-carboxylic acid is an impurity of Mesalazine and an active metabolite of sulfasalazine.

Mesalazine Impurity S (Product code - PA 13 23190, CAS No.-     1797983-23-3), which is chemically known as 2-Hydroxy-5-Amino-N-(2-carboxy-4-aminophenyl)benzoic Acid is an impurity formed during the synthesis of Mesalazine

All the above-mentioned standards are available in highly pure form (more than 98%), in pack sizes of 25mg and 50mg.We can make you available with the customized pack sizes as per your requirements.

A Certificate of Analysis is also provided with each standard along with the detailed structure elucidation data including chromatograms.

12 April 2016: 0915 My nose often bleeds when I blow it these days and I wonder if one of my medications - mercatopurine or remicade? I doubt it’s mesalazine - is thinning the membranes. @squats-4-pinkcupcakes do any of your UC patients find this? I guess I should google it but if any other spoonies have experienced it, let me know! @mynewnormaluc? @lifeaccordingtocrohns? I have been on drugs for so many years and of course there’s my age; maybe it’s a menopause thing - it seems all fine membranes are a bit delicate these days 👀. Nurses? @deartreadmill?