#immunomodulation

Colostrum, the initial milk produced by mammals after birth, shows promise in managing inflammatory bowel disease (IBD). Research suggests it has several beneficial effects in IBD:

Immunomodulatory Properties: Colostrum contains bioactive components like growth factors, immunoglobulins (especially IgA & IgG), cytokines, and lactoferrin. These help regulate the immune response in the gut, potentially reducing inflammation in IBD.

Anti-inflammatory Effects: Components like lactoferrin and immunoglobulins in colostrum exhibit anti-inflammatory properties by modulating gut inflammation pathways, contributing to IBD symptom relief.

Intestinal Barrier Protection: Colostrum contains factors supporting the intestinal barrier integrity, crucial in IBD. Growth factors like epidermal growth factor (EGF) and transforming growth factor-beta (TGF-β) help preserve this barrier, aiding in IBD management.

Antimicrobial Activity: Colostrum components like lactoferrin and antimicrobial peptides possess antimicrobial activity against pathogens, including bacteria and viruses. This may alleviate IBD flare-up symptoms by reducing microbial load and maintaining gut balance.

Nutritional Support: Rich in essential nutrients like proteins, vitamins, and minerals, colostrum supports gut health, aiding tissue repair and regeneration in inflamed intestinal mucosa, vital in IBD healing.

Tolerance Induction: Colostrum contains factors promoting immune tolerance, potentially reducing autoimmune responses seen in IBD. This may aid in preventing exacerbations and maintaining disease remission.

Overall, colostrum shows therapeutic potential in managing IBD by modulating the immune response, reducing inflammation, preserving intestinal barrier function, exerting antimicrobial activity, providing essential nutrients, and promoting immune tolerance. However, further clinical studies are needed to fully understand its mechanisms and efficacy in IBD treatment.

NuviaLab Immune is a food supplement, which supports the functioning of the immune system in a comprehensive way. The product contains the highest quality plant extracts that help increase immunity and accelerate regeneration. In addition, the supplement strengthens the body and has a positive effect on overall health. NuviaLab Immune is recommended for people who want to improve their mood, increase efficiency and support the body's defence mechanisms. NuviaLab Immune - Comprehensive Support for Your Body!

NuviaLab Immune capsules are a combination of 7 natural ingredients, such as: Japanese pearl flower extract, yeast extract, elderberry extract, rosehip extract, zinc, rutin and high dose of vitamin D. Customers love NuviaLab Immune!

Immunomodulators - helps in the modulation of the immune system. Immunomodulation is the process that is used to modify the immune response. ZCure nanospray is a branded formulation of metadichol that can help in immunomodulation and also helps in supporting the whole body's homeostasis.

Issues Need to be Resolved With ImmunoModulatory Therapies: NK cells, mAbs, and adoptive T cells

Issues Need to be Resolved With ImmunoModulatory Therapies: NK cells, mAbs, and adoptive T cells

Curator: Stephen J. Williams, PhD

                        Immunotherapy. 2014;6(3):309-20. doi: 10.2217/imt.13.175.

Optimizing NKT cell ligands as vaccine adjuvants.

Carreño LJ1, Kharkwal SS, Porcelli SA.

Author information Abstract

NKT cells are a subpopulation of T lymphocytes with phenotypic…

Stem cells are known for their unique ability to become other types of cells that are specific to various tissues such as bone, cartilage and nerves. One important feature of stem cells that is often overlooked, is their ability to control or “modulate” how the body produces an immune response. This is known as immunomodulation. 

Cells of the immune system such as macrophages and T cells have the important role of helping fight off infections. However, sometimes they take their job a bit too seriously and do more harm than good by producing molecules that damage the surrounding tissue! 

Certain types of stem cells have the ability to control and even transform these immune cells by what is known as a paracrine effect. This means that a stem cell can produce molecules that can either calm down a “damaging” immune cell, or convert it into a tissue repairing cell. Although the mechanisms by which this happens are still being researched, this amazing aspect of stem cells holds great promise for treating inflammatory diseases such as rheumatoid arthritis and asthma.  

Acute Lung Injury

Larry H. Bernstein, MD, FCAP, Writer and Curator

http://pharmaceuticalintelligence.com/Acute_Lung_Injury

Acute Lung Injury

Introduction

Acute lung injury is a serious phenomenon only recognized as having significant relevance to allogeneic blood transfusion in the last 15 years.  It is not limited to transfusion events, and is also related to SIRS and sepsis.  It is simulated in…

Common parasites such as Blastocystis and Dientamoeba fragilis are often incriminated of causing chronic or intermittent diarrhoea or other intestinal symptoms despite the absence of compelling evidence. What most of us probably fail to realise is that parasites may actually prevent and ameliorate intestinal illness, including inflammatory bowel disease, other types of colitis, and other types of autoimmune diseases.

Inflammatory bowel disease (IBD) includes the two most common manifestations ulcerative colitis and Crohn’s Disease and affects more than 2 million people in North America and Europe. They are chronic inflammatory conditions of the gut that usually begin when people are in the second to third decade of life. Although the causes of these inflammatory diseases remain unknown, they are assumed to result from inappropriately aggressive mucosal (i.e. related to our intestinal lining) immune responses to elements or substances in our intestine. IBD is treated with immuno-suppresive drugs. IBD has emerged primarily in the Western world along with a significant reduction in cases of intestinal helminthiasis due to clean food and water, improved hygiene and sanitation, and the development and use of antibiotics. In Denmark, helminthic infections due to previously common parasitic worms such as Ascaris (roundworm) are now at the point of being almost extinct in the indigenous population. The hygiene hypothesis proposes that a causal link exists between the adoption of modern hygiene and the increase in the prevalence of immune dysfunctions. The extent of perinatal maturation of the immune system may play a crucial role in terms of our likelihood of developing allergic and autoimmune diseases later in life. The maturation process includes establishment of tolerance to food and harmless microorganisms, but also defence mechanisms against pathogens. If our environment is "too clean", we may fail to give our immune system the best possible opportunity to mature and differentiate appropriately. A robust immune response will protect us from recurrent infections, but if misdirected, it can cause disease. Part of our immune system is the "adaptive immune system" -  or our "immunologic memory" - made up by cells such as lymphocytes (T- and B-cells), macrophages, dendritic cells, etc. plus antibodies and hormone-like substances (eg. cytokines) that are secreted to activate/inactivate or up- and down-regulate these cells. Our immune systems has to be able to recognise a plethora of foreign material such as bacteria, viruses and parasites, and to distinguish "self" from "non-self". IBD may be caused by mal-functions in our own immune system, and so may a lot of other diseases, diseases that we call "autoimmune diseases", and which include coeliac disease, multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. 10,000 years ago, humans were infected by a variety of species of worms that are common in some parts of the world even today and hence humans and parasites have co-evolved over thousands of years. Importantly, most wild animals in their natural habitat are carriers of many types of parasites. A "clever" parasite does little harm to its host. Parasites have developed mechanisms that enable them to survive in their hosts, and also, the human immune system has developed a way to adapt to these common intruders.

Eggs of Trichuris trichiura (photo: Anders Magnusson)

How can one explain the amelioration of symptoms due to colitis by the presence of intestinal nematodes? Helminths appear to induce immune host regulatory cells that suppress inflammation, and helminth infections are strong inducers of immune regulatory circuits. The immune system changes in response to helminth colonisation and factors secreted by helminths that can influence immune cell function. It is likely that several immune-regulatory mechanisms are exploited by individual helminths. Otherwise, a helminth could not reliably evade our immune system to reproduce.

A new study has produced data that suggest that treatment of macaques suffering from chronic diarrhoea with eggs of the whipworm Trichuris suis can alleviate symptoms and modulate both the intestinal microbiota and immunoregulatory pathways. Trichuris suis is the whipworm of the pig, and contrary to Trichuris trichiura (image), T. suis appears not to be able to produce disease in primate hosts (including humans). When T. suis ova (TSO) are administered to humans, transient shedding of ova in faeces may be seen after a few weeks, but the individual remains asymptomatic.

Gene expression profiling of colonic biopsies from the macaques treated with TSO revealed upregulation of genes typically involved in the socalled Th1-type immuno-response prior to TSO challenge, while induction of the Th2-type response followed after the TSO challenge; the Th2-type response resulted in mucosal repair, probably by increasing mucus production and turnover of epithelial cells, which again led to a reduction of bacterial attachment to the gut lining and a restoration of microbial diversity.

Briefly, a Th1-type response is generally a pro-inflammatory response that, among many other things, is responsible for microbicidal actions and perpetuating autoimmune responses. Excessive pro-inflammatory responses can lead to uncontrolled tissue damage, so there needs to be a mechanism to counteract this. The Th2­-type response includes the secretion of the anti-inflammatory cytokines, co-responsible for a general anti­-inflammatory response. In excess, Th2-type responses will counteract the Th1-mediated microbicidal action. The optimal scenario would therefore seem to be that humans should produce a well balanced Th1- and Th2-type response, suited to the immune challenge. On top of the immunoregulatory impact, there is emerging evidence that helminths promote the growth and expansion of groups of bacteria that are beneficial or "probiotic" to the host. In the study of the macaques, the TSO induced a change in the intestinal microbiota. While variation in160 genes in the human genome or more have been associated with increased risk of developing IBD, no specific gene variant that is sufficient or required for dysregulated mucosal inflammation as occurs in Crohn's disease or ulcerative colitis has been identified so far. There is a field of thought now saying that - over thousands of years - the human gut flora, including helminths, drove the development of variations in genes orchestrating various immune response pathways, and such genetic variations selected to operate under the influence of helminth infection could cause disease when operating without that influence. So, the take home message here is that infestation by intestinal parasites may be a double-edged sword: While on one hand they may cause symptoms, they may on the other hand prevent us from developing inflammatory bowel disease and other autoimmune or allergic manifestations. Hence, helminths, although parasites, may contribute something in return to their hosts, and the loss of helminths removes a natural governor that helped to prevent disease due to immune regulation. Of course, more trials are needed before "helminth therapy" can actually be standardised, commercialised and used in the prophylaxis and treatment of IBD and gut allergic conditions. Once  a good mechanistic understanding of how helminths alter immunity is available, it may even be possible to apply identified factors individually or in combination to treat disease. As always, things are much more complex than presented here, but this post gives an impression of the fields of thought. Not all autoimmune diseases are driven by excessive Th1-type responses; some types of asthma may be driven by Th2-type response, but even here, helminths may favourably modulate immunoregulatory pathways. Obviously, it would be interesting to explore how other parasitic infections impact on our immune system and gut flora. Interestingly, one helminth species appears to have "survived" in our "sterile" environment, - the pinworm (Enterobius)... and as pointed out in one of my recent blog posts (go here), many of us are definitely exposed to parasites that persist in our intestines for months, maybe years. What's their role in all of this? Further reading: Dirtying Up Our Diets - go here.  Parasitic Worm Eggs Ease Intestinal Ills By Changing Gut Microbiota - go here. Jostins L, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature, 491 (7422), 119-24 PMID: 23128233

Berger, A. (2000). Science commentary: Th1 and Th2 responses: what are they? BMJ, 321 (7258), 424-424 DOI: 10.1136/bmj.321.7258.424  

Elliott, D., & Weinstock, J. (2012). Where are we on worms? Current Opinion in Gastroenterology, 28 (6), 551-556 DOI: 10.1097/MOG.0b013e3283572f73  

Elliott, D., & Weinstock, J. (2012). Helminth-host immunological interactions: prevention and control of immune-mediated diseases Annals of the New York Academy of Sciences, 1247 (1), 83-96 DOI: 10.1111/j.1749-6632.2011.06292.x  

Weinstock, J. (2012). Autoimmunity: The worm returns Nature, 491 (7423), 183-185 DOI: 10.1038/491183a