#sepsis

"Canadian scientists have developed a blood test and portable device that can determine the onset of sepsis faster and more accurately than existing methods.

Published today [May 27, 2025] in Nature Communications, the test is more than 90 per cent accurate at identifying those at high risk of developing sepsis and represents a major milestone in the way doctors will evaluate and treat sepsis.

“Sepsis accounts for roughly 20 per cent of all global deaths,” said lead author Dr. Claudia dos Santos, a critical care physician and scientist at St. Michael’s Hospital. “Our test could be a powerful game changer, allowing physicians to quickly identify and treat patients before they begin to rapidly deteriorate.”

Sepsis is the body’s extreme reaction to an infection, causing the immune system to start attacking one’s own organs and tissues. It can lead to organ failure and death if not treated quickly. Predicting sepsis is difficult: early symptoms are non-specific, and current tests can take up to 18 hours and require specialized labs. This delay before treatment increases the chance of death by nearly eight per cent per hour.

[Note: The up to 18 hour testing window for sepsis is a huge cause of sepsis-related mortality, because septic shock can kill in as little as 12 hours, long before the tests are even done.]

[Analytical] AI helps predict sepsis

Examining blood samples from more than 3,000 hospital patients with suspected sepsis, researchers from UBC and Sepset, a UBC spin-off biotechnology company, used machine learning to identify a six-gene expression signature “Sepset” that predicted sepsis nine times out of 10, and well before a formal diagnosis. With 248 additional blood samples using RT-PCR, (Reverse Transcription Polymerase Chain Reaction), a common hospital laboratory technique, the test was 94 per cent accurate in detecting early-stage sepsis in patients whose condition was about to worsen.

“This demonstrates the immense value of AI in analyzing extremely complex data to identify the important genes for predicting sepsis and writing an algorithm that predicts sepsis risk with high accuracy,” said co-author Dr. Bob Hancock, UBC professor of microbiology and immunology and CEO of Sepset.

Bringing the test to point of care

To bring the test closer to the bedside, the National Research Council of Canada (NRC) developed a portable device they called PowerBlade that uses a drop of blood and an automated sequence of steps to efficiently detect sepsis. Tested with 30 patients, the device was 92 per cent accurate in identifying patients at high risk of sepsis and 89 per cent accurate in ruling out those not at risk.

“PowerBlade delivered results in under three hours. Such a device can make treatment possible wherever a patient may be, including in the emergency room or remote health care units,” said Dr. Hancock.

“By combining cutting-edge microfluidic research with interdisciplinary collaboration across engineering, biology, and medicine, the Centre for Research and Applications in Fluidic Technologies (CRAFT) enables rapid, portable, and accessible testing solutions,” said co-author Dr. Teodor Veres, of the NRC’s Medical Devices Research Centre and CRAFT co-director. CRAFT, a joint venture between the University of Toronto, Unity Health Toronto and the NRC, accelerates the development of innovative devices that can bring high-quality diagnostics to the point of care.

Dr. Hancock’s team, including UBC research associate and co-author Dr. Evan Haney, has also started commercial development of the Sepset signature. “These tests detect the early warnings of sepsis, allowing physicians to act quickly to treat the patient, rather than waiting until the damage is done,” said Dr. Haney."

September is Sepsis Awareness Month and since this is a serious condition that affects millions every year, I think we should all know more about it...

Spotting symptoms early could prevent the body from entering septic shock, and could save a life. The Sepsis Alliance recommends the acronym TIME:

T – Temperature higher or lower. When you have an infection, your body’s temperature usually rises as it tries to fight off the bug causing the infection. Interestingly, some people see their body temperature go down (hypothermia) instead of up. This is why any change, high or low, can be a sign of sepsis.

I – Infection. The person may have signs and symptoms of an infection. Sometimes however, they may have an infection and not know it, and not have any symptoms. Keep this in mind especially if they have recently had surgery or an invasive medical procedure, a break in their skin, or been exposed to someone who is ill.

M – Mental decline (confused, sleepy, difficult to rouse). Some people, especially the elderly, may not show typical signs of infection. Instead, they may show a sudden change in mental status, becoming confused, or a worsening of dementia and confusion. Sleepiness, often severe, is also a common complaint.

E – Extremely ill (severe pain or discomfort, shortness of breath). Many sepsis survivors have said that when they were ill, it was the worst they ever felt. It was the worst sore throat, worst abdominal pain, or they felt that they were going to die.

➡️ For every hour treatment is delayed, the risk of death increases by as much as 8%.

https://www.change.org/p/protect-kent-students-close-campus-during-meningitis-sepsis-outbreak

That is absolutely fucked, everyone please sign and share this petition. Meningitis can cause death or lifelong brain damage, and sepsis is STILL one of the leading causes of death worldwide and one of the most fatal diseases in existence. More people will die if this university stays open.

Pregnancy became far more dangerous in Texas after the state banned abortion in 2021, ProPublica found in a first-of-its-kind data analysis.

The rate of sepsis shot up more than 50% for women hospitalized when they lost their pregnancies in the second trimester, ProPublica found.

The surge in this life-threatening condition, caused by infection, was most pronounced for patients whose fetus may still have had a heartbeat when they arrived at the hospital.

ProPublica previously reported on two such cases in which miscarrying women in Texas died of sepsis after doctors delayed evacuating their uteruses. Doing so would have been considered an abortion.

The new reporting shows that, after the state banned abortion, dozens more pregnant and postpartum women died in Texas hospitals than had in pre-pandemic years, which ProPublica used as a baseline to avoid COVID-19-related distortions. As the maternal mortality rate dropped nationally, ProPublica found, it rose substantially in Texas.