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god i wish more sources talked about "sex" hormones like this
ironically its in a book about female sex anatomy that ive come across it (Vagina Obscura by Rachel E. Gross). everyone only wants to focus on the secondary sex characteristics and not the bazillion other functions of estrogen, testosterone, and co.
every body uses both of them!! for a million reasons!!!!! aaaaaa!!!!!!!
❝They had battled and bloodied one another, they had kept secrets, broken hearts, lied, betrayed, exiled,
They had walked away, said goodbye
and sworn it was forever
And somehow, every time, they had mended, they had forgiven, they had survived.
Some mistakes could never be fixed - some, but not all. Some people can't be driven away, no matter how hard you try. Some friendships won't break.❞ – Robin Wasserman
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turns out i wasn't making that up, his name is Dr. Toru Miyazaki! he also wrote a book called "The Day Cats Live To Be Thirty", so cats are kind of his thing.
apparently, cats' kidneys tend to be the thing that takes them down, something about their bodies being unable to self-clean their kidneys, and the vaccine is supposed revitalize the body's ability to do just that. It would be very VERY fucking cool to have cats suddenly reaching 30 years of age be the normal thing.
As they age, almost all cats develop kidney disease, from which they eventually die. Just as in humans, kidney disease i
Dr. Toru Miyazaki’s AIM injection for cat kidney disease enters trials in 2025, aiming for a 2027 release. Greycoat Research supports the sc
whoa wait i actually read the articles and it's so much cooler than just that!!
dude cracked the case about WHY kidneys fail, across the board as far as i can tell. turns out there's a specific molecule whose job it is to attach to waste and signal macrophages to come eat it. it remains inactive in cats for some reason, but the molecule is still there. basically what he's done is found the switch to activate them. this will be profound not only for our domestic babies, but for big cats too - especially cheetahs!
although his research was focused on cats, it's already being used to develop drugs for humans too!
on top of that, since these molecules are tags for waste, this could also dramatically lower the rate of fatty liver disease, liver cancer, urinary crystals, rheumatoid arthritis, and even some neurological cases! like, they're hoping it may have an impact on parkinson's and alzheimers, but it DOES have an impact on stroke recovery. like. holy shit.
furthermore, he's insisting that the feline drug be affordable if and when it rolls out onto the market. he wants this to be something anyone can get for their cat!! idk how much sway he'll have over the human drug, but hopefully enough that it, too, won't be that expensive.
annnnnd in his research that he's still doing for the human side of things, he's found a potential link between this molecule and estrogen. in the 20,000 samples he's tested, women between ages 10 and 29 had the highest amount of this molecule present in their blood (a higher amount means Something Fucky is going on, essentially. There's a higher amount of waste the body is trying to clean out) but it drops down to be almost equal amongst men and women after menopause. it hasn't been looked into yet, but fuck, just the fact it's noted and known and probably WILL be looked into soon??? imagine if this is what leads to figuring out all the various ways the ovaries and uterus fucks with people and how to fix it. or even like, maybe there's something about estrogen that makes it work better. who knows! but it's rad the link is there to be researched :D
man just think, not only could our kitties start living longer, healthier lives, but just maybe dialysis will become as rare and obsolete as the iron lung is for people. what a badass Dr. Toru is!
Update: So they have done clinical trials and have submitted it for approval as of april 2026. They are expecting it to be available late 2026/early 2027
The AIM protein drug for feline chronic kidney disease has been submitted for approval in Japan (April 2026). We break down clinical trial d
As for the study itself, the 360 day follow up on stage 3 kidney failure kitties showed that the control had a survival rate of about 20%, while the test group had a survival rate of 80%
New 2026 study: AIM protein boosts cat kidney disease survival from 20% to 80%. Discover how this scientific breakthrough is changing the fu
Day 17 of Ineffable Valentines and the prompt was pillow talk. I went completely ace with this one, and hoped to give fans that missing scene we all wanted. I don’t know why I’m so excited by this, there are plenty of technical mistakes I could fix if there’d been time, but I love it.
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Welp, it's been about a month, and I finally have the energy to try to convey my thoughts on the Good Omens finale. Yeah, I know, old news at this point, but what's the point of Tumblr other than talking to myself about my feelings?
Anyways, this is coming from someone who isn't a massive, longterm GO fan. I did not wait years for this finale. I am not heavily bound to these characters (though I have developed my usual maternal feelings towards Crowley pretty quickly, so there's that). I didn't go through the emotional upheaval surrounding the news that the writer is a vile sexual predator. Essentially: I don't go here. I'm not an appreciable part of this fandom.
So I feel like it means something kind of negative when the finale had even me - all but an outsider - kind of grimacing at her screen.
Again: I don't have an extensive history with this series. I watched S1 years ago, liked it fine, and promptly forgot about it. Fast forward a few years later, and it's February 2026. I get the sudden urge to rewatch the David Tennant era of Doctor Who from my college days, but I am also cognizant of the fact that I am an emotionally delicate little cupcake and don't really want to sob on my couch for multiple hours. So! For some silly reason, I decide that watching Good Omens will provide me with some Tennant enjoyment without the emotional commitment.
...this was a mistake, obviously. Y'all can see that coming, but I did not at the time. So I went ahead and fired up S1, enjoyed it again, and followed it with S2. S2 was... well. That last bit, eh? What do y'all call it... the Final Fifteen? Is that right? Yeah. Yeah, that was upsetting.
But! Fear not, sad little me, for S3 is just around the corner! I managed to get into this right before the conclusion, escaping years of doubt and longing and potential disappointment.
Aaaaaand then I watched it.
I watched it like... a week or two after it came out. After watching the general reception and just kind of steeling myself for it. I'd become attached to Crowley. I enjoyed Aziraphale as well, and their relationship had grown on me significantly in just a few months. I'd read bits and pieces of the original book, and I enjoyed them there, too. So I was trying to prep myself for the emotional disappointment, y'know?
But when I finally watched it, I was less disappointed and more just... weirded out? I think that's the best way of putting it? Like, the whole thing felt so disjointed, so strange, so thematically removed from the S1 and book that I enjoyed, that my normally canon-focused brain just kind of rejected it. I wasn't sad simply because the whole thing just didn't feel like an actual, in-character, thematic conclusion to the story.
The whole conflict surrounding free will: S1 and the book made it pretty clear that free will existed? I think? Like, that was part of the comedy: Heaven and Hell go through all of these motions to influence things, but at the end of the day, humans are just like "meh, we'll do what we want, thanks." Like, that was funny! Crowley doing dumb, annoying things to try to foment evil while simultaneously sabotaging himself and also never coming up with the level of evil humans came up with was funny! Angels kind of being bureaucratic assholes was funny!
It was funny, and it was wholesome. An angel and a demon forging a longterm bond simply because they felt more understood by one another than by their "sides" was wholesome. The Antichrist telling Satan to fuck off so he could go live a normal kid life with his newly-liberated hellhound was wholesome.
And now, as of S3, those things didn't matter? None of it happened? What? Why? What in the world was the point of *gestures* All Of That? Why even bother?
The whole concept of fighting for your current world, of striving to survive and repair things the best you can, of valuing the people and creatures around you for what they are... all of it is just gone. Everyone is gone. None of it ever happened? What. Why would you write it that way. Why would you essentially destroy the entire everything of the actual, canonical book that had established themes and a satisfying conclusion? Why would you rewrite it as "nah, this whole mess is too far gone, so we have to let it die and also destroy ourselves in the process; give the audience a bunch of body doubles living happily afterwards in a world that means nothing to them"?
And S2! Like, S2 on its own seemed less organized and realized than S1, but I figured that that was because it was to be paired with S3 in completing its arcs and developing its themes. Instead, literally everything that happens in S2 is just... pointless?
Like, what the hell was the point of Gabriel and Beelzebub? Why in the world did we spend six episodes chasing Gabriel's memories around and learning of his relationship with the Duke of Hell only for it to not matter in the slightest?
Then there was the Job flashback: a whole plot making it very clear that killing everyone and replacing them with new versions was not the same. Both Azi and Crowley knew this. It was emphasized heavily. And then S3 comes along and we just... ???
God was changed from a creature I actually kind of liked in S1 (passive, kind of eldritch and unknowable, not actually malicious) to the sort of asshole I interpret (and hate) the actual Christian god being. Callous and vaguely entertained by the trials and sufferings of what were essentially her own children whom she was supposed to love. Her detached amusement over Crowley and Aziraphale's entire relationship was actually infuriating to me. Her children were in such distress, and the way she treated them was repulsive to me. The idea that Azi spent his whole life trying to live up to the expectations of this narcissistic twit was... ugh.
The fact that no human characters even knew anything was going on, let alone were able to have agency in their world's fate felt so, so contrary to the vibes of the original work. And that's coming from someone who generally doesn't care for human characters: I was bothered by their omission because it upset the themes the story had so championed.
Gosh, what else... I feel like this is all so disjointed, but I have issues with basically all of it...
Jesus was pointless. Could have been removed from the plot, and nothing would have changed.
My sweet baby Muriel never had a chance to leave their sheltered existence.
Nina and Maggie are just gone? Anathema and Newt and The Them are gone? None of these people, who witnessed and were involved in supernatural affairs, had any sort of involvement with an attempted second apocalypse? Really?
The relationship between Azi and Crowley was just so sad in the end? Like they realized that there was no point in fighting for their own lives and their own relationship and just... gave up. After spending the whole S3 plot angry and upset and afraid and so unhappy with one another. None of it resolved before they both decide to die.
But CF, you may say, what did you expect to happen?
Jeez, I don't know. I'm not a writer. I'm not even a legit GO fan. I don't even go here. But from the way S1 was written, and the was S2 happened, I had some vague ideas of what would make sense.
I thought that Jesus would be a sort of parallel to Adam. In S1, Hell tried to initiate the End Times by sending their child to Earth. Said child took his free will and said "fuck off." Now in S3, it would have made sense to me if Jesus played a similar role: Heaven's child sent to end the world, only to take charge of his own destiny and tell his mother to fuck off. Would have been poetic for the two of them to come together somehow, y'know? Hell's child and Heaven's child coming together to say no and to save their world. A parallel to one of Hell's demons and Heaven's angels doing the same thing.
I thought that Gabriel and Beelzebub would have some bearing on things. Their love and their own, personal choice to leave and pursue their own freedom would act as proof that Crowley and Aziraphale aren't just weird outliers; all angels and demons have the capacity for free will. All have the capacity for love. All can decide to reject The Establishment and pursue their own happiness.
Oh, and the 25 Lazarii miracle! Dang, I thought it would mean something, that an angel and demon working together could achieve such a feat. I thought... I dunno... if the writers wanted to turn God antagonistic, perhaps it would involve some sort of reveal that the sides of Heaven and Hell were purposely being kept apart so that the angels and demons didn't realize the sort of power they had if they worked together. Power that could defeat their creator.
It may just be years of JRPGs and the enjoyment of His Dark Materials in my youth, but I was expecting them to kill God. Or something similar. Christ and Antichrist, aware humans, angels and demons coming together to wrest control of their freedom and their lives from the capricious asshole who created them. All of the people - mortal and immortal - who were oppressed and controlled and contained by this deity and their supposed plan waking up and realizing that they have the ability to free themselves from it.
I guess that's what I ultimately wanted: for all of these people to just be able to live their own lives. Peacefully. Without the fear of their masters hanging over their heads. The humans. Animals. The angels and the demons. Michael and Muriel and Beelzebub and the Erics. And especially Aziraphale and Crowley. Gosh but I wanted Azi and Crowley to just be able to live as themselves, share their lives with one another, without constantly worrying and fearing that they'd be found out and destroyed. I wanted them to have their cottage and their garden and their peace after millenia of doubt and fear. I wanted Azi to be able to enjoy food without guilt. I wanted Crowley to be able to do something kind without getting all defensive about it. I wanted peace for them, the poor dears.
And that's just after thinking about these characters for a few months. I can't even imagine the pain visited upon people who are Bound to this story and these characters. I am so, so sad for people who waited years and had their hearts broken.
There's more I could say. More plot details that are weird, character details that don't work for me. A lot more, but I think I've reached the limit of my coherence for now. Maybe I'll post more later, if I can organize my thoughts again.
*sigh* The only saving grace for me personally is that it all feels so contrary to the established themes. Even to the general vibe of the characters and story... so much so that I can actually reject it in my brain's understanding of canon. Which is normally incredibly difficult for me to do. I'm normally such a canon purist, but this... this feels so off. To the point that the rejection of it doesn't even feel like coping to me; it just feels like a logical conclusion.
Somewhere Anathema Device caught a glimpse of something in Agnes Nutter’s second book of prophecies, gasped, pulled it out of the fire, got Newt to drive at top speed down the M25 (somehow magically free) dashes into Soho, runs into the bookshop, slams the book down on the counter in front of Aziraphale and Crowley and screams
‘Don’t you two FUCKING dare!’
And leaves.
Several large coffees, bottles of wine and a pile of Eccles cakes and a very long reading and interpretation session later Crowley sits back.
‘Beelzebub and Gabriel, huh? Did not see that coming.’
‘Never mind that, dear,’ Aziraphale says, as he continues carving symbols onto the floor. ‘There. That should do it. The Metatron can’t get in here now.’
‘And you?’ Crowley asks delicately. Aziraphale stands up and primly clasps his hands across his stomach.
‘I have no intention of going up to heaven under any circumstances and especially not now I know how it ends.’ He says. It’s his I Will Not Be Moved tone. Crowley knows it well. He is reassured.
‘Well, maybe pop up and get Muriel. But after that we seal up that lift, agreed?’ Crowley adds.
‘Agreed.’
‘Excellent. Dinner at the Ritz called for I think, to celebrate a very lucky escape. Coming, Angel?’
‘One thing…’ Aziraphale says, and Crowley notices the cheeks of his Angel have gone a little pink, and he is turning that ring on his finger round and round. ‘Prophecy number 547.’
‘547? Was that the one with the butterflies the size of giraffes?’
‘It was not,’ Aziraphale says.
Crowley takes a step closer. He always did enjoy this bit of the temptation, although he was not quite sure who was being tempted right now.
‘Ah, the one with the Welsh Choir serenading the Kraken with excerpts from popular musicals.’
‘No, not that one either.’ Aziraphale appears to have flushed a deep red.
Crowley takes a step closer now. He can feel it - the tingle in his fingers and on his lips.
There’s another first time coming. To add to the Wall, and the Temptation of the Ox Ribs and the Rescue of the Books and all those other first times that have led them step by step to this place.
A first time they had in any timeline, but this would their first time - they, Aziraphale and Crowley in this world, their world.
‘Oh, I know, the one with the crystal the exact size and shape of…’
‘Crowley!’ Aziraphale snaps. ‘You know which one I mean.’
‘Oh,’ Crowley says softly. ‘The one where I tell you there’s an us.’
‘That’s the one,’ Aziraphale says, glancing down at the ground. ‘Of course, if you’d rather not, I understand, it’s asking too much, it’s…’
‘Angel,’ Crowley says, and he steps forward, taking off his glasses, and looks down at his angel, his enemy and ally, his closest friend. His love since he knew what love meant. ‘We have always been an us. We don’t need a prophecy for that.’
And Aziraphale, a soft and gentle angel, not a soldier or a leader, becomes a hero for that moment, and clasps Crowley’s collar and pulls him in for a kiss.
It was a nice day. It would always be a nice day. There would always be a bookshop, and later a garden. Nightingales would always sing and there would be many many kisses to follow that first kiss.
To be quite honest with you all I do think that aro/ace-spectrum fans in fandoms where people are desperately inventing crossover ships and humanizing non-human characters in order to have a conventionally attractive guy to ship the main character with, instead of possibly having to enjoy a story with no romance in it, have the right to refer to everyone else as cowards.
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not only is he a movie-only character, but it was supposed to be a tiny part. the actor, Lionel Boyce, was originally hired for just 1 day of filming! according to his interviews & the directors commentary, he got along so well with ryan gosling & everyone that they just kept writing scenes for him and he was on set for a month
I’ve grown up in an age that told me that denying yourself was good. Oh, you want cake? Here, have this chalk-dust square of not-cake - fewer calories, don’t you know! You want to lay on the sofa and read? Don’t you think you ought to clean the entire house first? Then perhaps you’ll deserve ten minutes. Make sure it’s approved book though - no reading purely for pleasure!
And most importantly - you must work hard to maintain yourself and your life in a certain way or no one will love you!
You know, the sort of thing S1 Gabriel said.
And then there’s Aziraphale who loves food and books and peace and his comfy clothes and his music and he is deeply loved by his demon who wants him to love all that. Aziraphale just wants a soft, sweet, delicious life - not a soldier or a leader, to just be him.
And Crowley loved that about him.
I just think that was very important about S1 Aziraphale (and not something that made much of after that) and it felt like I was being given permission to enjoy my life and I would still be able to be loved and to achieve things, even if I’d rather eat cake.
I think S2 and S3 forgot that about Aziraphale but I think that soft hedonism is a hugely important part of his character
blakekathryn
baratheonpilled
areudirty
tangentwithtanner
stormborns
