PSA:
Acetaminophen/paracetamol has a hard stop upper dose limit, above which it becomes extremely toxic.
That limit is 4g (8 “extra strength” (500mg) tablets) in 24 hours (about 2 tablets every 6 hours).
A single dose of 22 extra strength tablets can kill you.
Taking 12 or more tablets per day for more than a week can also kill you (this is about 3 tablets every 6 hours).
Symptoms of overdose take up to 24 hours to manifest, and are fairly difficult to distinguish from other problems. They include abdominal pain (especially right upper quadrant), nausea, malaise, and confusion.
The antidote (n-acetylcystine) must be given within 8hours of ingestion in order to be useful.
After 10 hours the only thing that will work is a liver transplant.
You might think “why would I ever accidentally take so much?”
Well, acetaminophen is in almost everything in the cold/flu/pain aisle. Migraine combos like Excedrin, cold and flu combos like NyQuil, basically anything that says “non-aspirin pain relief”, and anything that’s branded as a fever reducer. It’s all probably acetaminophen/paracetamol.
So the goal of this post is to get you to read the labels on your medications. Because taking taking Tylenol and NyQuil together for a week (like you might if you had the flu) could kill you.
it is also one of the easiest medications to obtain in many countries and people frequently intentionally overdose on it and often think they're fine because of the lack of symptoms for the first day. There's been many tragic incidents of young people dying this way and more people need to be aware that just because it's easy to obtain doesn't mean it can't be extremely dangerous or lethal.
another generic name for acetaminophen is paracetamol and is also commonly sold in combination with ibuprofen
