I'm sarcastic

In the episode 72 hours, we find out Rose may have contracted AIDs during an emergency gallbladder surgery.

Rose: Why me, Blanche? I'm tired of pretending I feel okay so you won't say, 'Take it easy', and I'm tired of you saying 'Take it easy' because you're afraid I'm going to fall apart. Dammit, why is this happening to me? I mean, this isn't supposed to happen to people like me. You must've gone to bed with hundreds of men. All I had was one innocent operation. Blanche: Hey, wait a minute! Are you saying this should be me and not you? Rose: No! No, I'm just saying that I am a good person. Hell, I'm a goody-two-shoes! Blanche: AIDS is not a bad person's disease, Rose, it is not God punishin' people for their sins!

In Isn't it romantic? we find out Dorothy's childhood best friend is a lesbian who recently lost her partner. She confesses she has feelings for Rose. Rose turns her down but makes it clear that she still wants to be friends even though she doesn't return those feelings.

Sophia: Jean is a nice person. She happens to like girls instead of guys. Some people like cats instead of dogs.

Jean: Rose, about last night. I should never have said anything. Rose: You only said what you were feeling. Jean: It's just that this last year has been so difficult for me. Pat was the person I planned to spend the rest of my life with. And when she died, I just felt so terribly alone. Empty. I thought I could never care for anyone again. Until I met you. I just got very confused. I hope I didn't make you uncomfortable. Rose: Well, I have to admit that I don't understand these kinds of feelings. But if I did understand, if I were, you know, like you, I'd be very flattered and proud that you thought of me that way.

Ebbtide's Revenge gives us Phil's funeral, and Sophia addressing him wearing women's clothes.

Rose: So what if he was different? It's okay that you loved him. Sophia: I did love him. He was my son, my little boy. But every time I saw him I wondered what I did, what I said, when was the day I did whatever I did to make him the way he was. Angela Petrillo: What he was Sophia, was a good man.

Sister of the Bride, where Blanche's brother Clayton brings his boyfriend to town, because they're planning on getting married.

Blanche: Oh, look, I can accept the fact that he's gay, but why does he have to slip a ring on this guy's finger so the whole world will know? Sophia: Why did you marry George? Blanche: We loved each other. We wanted to make a lifetime commitment. Wanted everybody to know. Sophia: That's what Doug and Clayton want, too. Everyone wants someone to grow old with. And shouldn't everyone have that chance?

Her cool, cultured, interesting friend starts to show who she really is when she wants to take Dorothy out to a nice place... but no Jews allowed. This was not uncommon IRL. Perfectly acceptable, even.