Trash Panda

if something wants to get at your blood, and they’re, say, some kind of murdersaurus, or maybe a really big frog, that’s where the problems start to arise. a really frog is not made for removing blood, and your blood knows this, which is why it is so vehement about wanting to stay IN your body instead of coming out. 

apparently, cats' kidneys tend to be the thing that takes them down, something about their bodies being unable to self-clean their kidneys, and the vaccine is supposed revitalize the body's ability to do just that. It would be very VERY fucking cool to have cats suddenly reaching 30 years of age be the normal thing.

dude cracked the case about WHY kidneys fail, across the board as far as i can tell. turns out there's a specific molecule whose job it is to attach to waste and signal macrophages to come eat it. it remains inactive in cats for some reason, but the molecule is still there. basically what he's done is found the switch to activate them. this will be profound not only for our domestic babies, but for big cats too - especially cheetahs!

although his research was focused on cats, it's already being used to develop drugs for humans too!

on top of that, since these molecules are tags for waste, this could also dramatically lower the rate of fatty liver disease, liver cancer, urinary crystals, rheumatoid arthritis, and even some neurological cases! like, they're hoping it may have an impact on parkinson's and alzheimers, but it DOES have an impact on stroke recovery. like. holy shit.

furthermore, he's insisting that the feline drug be affordable if and when it rolls out onto the market. he wants this to be something anyone can get for their cat!! idk how much sway he'll have over the human drug, but hopefully enough that it, too, won't be that expensive.

annnnnd in his research that he's still doing for the human side of things, he's found a potential link between this molecule and estrogen. in the 20,000 samples he's tested, women between ages 10 and 29 had the highest amount of this molecule present in their blood (a higher amount means Something Fucky is going on, essentially. There's a higher amount of waste the body is trying to clean out) but it drops down to be almost equal amongst men and women after menopause. it hasn't been looked into yet, but fuck, just the fact it's noted and known and probably WILL be looked into soon??? imagine if this is what leads to figuring out all the various ways the ovaries and uterus fucks with people and how to fix it. or even like, maybe there's something about estrogen that makes it work better. who knows! but it's rad the link is there to be researched :D

As for the study itself, the 360 day follow up on stage 3 kidney failure kitties showed that the control had a survival rate of about 20%, while the test group had a survival rate of 80%

"the day of emergence has come --- rejoice!"

This isn’t a poem I don’t think, just a 2 am ramble about my relationship with my sister and my transition and just needed to put it somewhere

Would you still love me if I was a worm?

Because I was

Because sometimes I think I still am

Part of me at least

I know you would love me if I was a worm

Because I was

And you did

I must have been a good worm

Nice

Helpful

Easily carried places and would settle

I was simple

Did you love me because I was a worm?

I hope not

Because I love you still

You are still one of the most important people in my life

I don’t want to think about a world without you

And yet when I stopped being a worm I had to be prepared for it

Because you loved me when I was a worm

But I didn’t.

Would you love me if I hated the worm

The worm you knew and loved

The worm you cherished

Would you still love the person who’d take a hammer to the worm if they could.

I want to say I’m not the worm

But I’m not sure

Because I can look in the mirror and see the worm

And I know

I know you look at me

And still see the worm

But the nice parts

The worm you love

But the worm’s dead

The worm was dead before I crawled out of its carcass

It’s just that neither of us knew it.

So please

Don’t love the worm I used to be

The worm I hate

I have switched to using Startpage.com and vastly prefer it. for one thing, instead of displaying an "AI summary" at the top of the search results (unless you turn it off, yes I know), it displays the first paragraph of the Wikipedia article, with link, whenever it finds one that's relevant.

also a waaayyyyy better sense of design than duckduckgo

Search Engines

Infinity Search is an alternative search engine with a special focus on privacy

DuckDuckGo is a popular search engine for those who value their privacy and are put off by the thought of their every query being tracked and logged. Uses bangs, ![site] for in-page search (sells your data to microsoft and draws from fucking bing)

WolframAlpha is a privately owned search engine that allows you to “compute expert-level answers using Wolfram’s breakthrough algorithms, knowledgebase, and AI technology.” A data search engine.

Boardreader is a search engine for forums and message boards. It allows you to search forums and then filter down results by date and language.

Based in France, Qwant is a privacy-based search engine that won’t record your searches or use your personal details for advertising. Uses “&” as a bang search.

Another privacy-based search engine is Search Encrypt, which uses local encryption to ensure that users’ identifiable information cannot be tracked. Metasearch across multiple engines. 

Offering unbiased results from several sources, SearX is a metasearch engine that aims to present a free, decentralized view of the internet. Can be self-hosted. 

Gibiru’s tagline is “Unfiltered private search” and that’s exactly what it offers. Requires AnonymoX Firefox add-on for privacy. 

Disconnect allows you to conduct anonymous searches through a search engine of your choice.

Swisscows provides fully encrypted searches to protect your privacy and security. Built-in violence/porn filter cannot be overridden. 

MetaGer offers “Privacy Protected Search & Find” through its anonymised search. A plugin will allow it to be made a default.

Gigablast is a private search engine that indexes millions of websites and servers real-time information without tracking your data, keeping you hidden from marketers and spammers. Variety of filtration and refinement options for searching. 

Oscobo is a search engine that protects your privacy while you search the web. By not using any third-party tools or scripts, your data is protected from hacking and misuse. Has a Chrome extension to allow use in toolbar. 

https://search.marginalia.nu/ an independent DIY search engine that focuses on non-commercial content, and attempts to show you sites you perhaps weren't aware of in favor of the sort of sites you probably already knew existed. Use old-school searching rather than query-based for the best results. 

https://www.mojeek.com/ 

https://wiby.me/ - It’s goal is to index as many personalized websites as possible, and NOT commercial sites. 

https://4get.ca/ it works a lot like SearX, but honestly better. It doesn’t have its own index, but pulls from many others. I think it’s the best for research, since it allows you to search for answers from different indexes, is easy to configure, add free, and avoids censorship as much as it can.

https://www.searchenginemap.com/ for more on how search engines relate to each other.

https://yep.com/ is a crawler

https://www.etools.ch/ retrieves from Google, Mojeek, Bing, and Yandex, like Searx

https://www.dogpile.com/ 

https://searxng.org/ (next gen Searx)

https://luxxle.com/ - possibly conservative?

https://presearch.com/ - good for academic?

https://kagi.com/smallweb - free/randomised Kagi.

Other Searchers

www.refseek.com - Academic Resource Search. More than a billion sources: encyclopedia, monographies, magazines.

www.worldcat.org - a search for the contents of 20 thousand worldwide libraries. Find out where lies the nearest rare book you need.

https://link.springer.com - access to more than 10 million scientific documents: books, articles, research protocols.

www.bioline.org.br is a library of scientific bioscience journals published in developing countries.

http://repec.org - volunteers from 102 countries have collected almost 4 million publications on economics and related science.

www.science.gov is an American state search engine on 2200+ scientific sites. More than 200 million articles are indexed.

She got the idea for the study while walking with her advisor at Stanford to discuss her thesis topic, and the paper she eventually published in the Journal of Experimental Psychology in 2014 is sharp enough that it should have ended the seated meeting on the day it came out.

She ran 4 experiments on 176 people. Same person tested twice. Once sitting, once walking. The creativity tasks were the standard ones psychologists have used for decades to measure how good a brain is at generating novel useful ideas.

81% of participants in the first experiment produced more creative ideas while walking than while sitting. In the second experiment, 88%. In the third, 100%. Every single person walked into a more creative version of themselves. On average, people generated 60% more novel useful ideas the moment their legs started moving.

The skeptical question is the obvious one. Maybe it was the fresh air. Maybe it was the scenery passing by. Maybe it was the change of environment doing the work, not the walking itself.

Oppezzo killed every one of those explanations with one experimental decision. She put people on a treadmill facing a blank wall. No scenery. No fresh air. No environmental change. Just legs moving in place while staring at white drywall. The 60% boost held.

Then she ran the experiment that closed the case completely. She took participants outside in two conditions. Half of them walked through a Stanford courtyard. The other half were pushed through the exact same courtyard in a wheelchair. Same outdoor stimulation. Same scenery passing at the same speed. The only difference was whether the legs were moving.

The walkers produced dramatically more novel high-quality ideas than the wheelchair group. The outdoors did almost nothing on its own. The walking did everything.

She also tested the opposite kind of thinking. Convergent thinking. The kind where there is one right answer and you have to narrow down to it. Word puzzles where 3 words share a hidden fourth word that connects them. The seated participants did slightly better on these. Walkers got slightly worse.

Walking is not a general intelligence enhancer. It does one specific thing. It opens up the divergent search inside your brain. The part that generates options. The part that produces unexpected connections. The part that takes a problem and finds five ways into it instead of one.

When you need to converge on the single right answer, sit down. When you need to find the answer in the first place, get up.

The mechanism is now well understood. Walking selectively activates what neuroscientists call the default mode network, the system inside your brain that runs when you are not consciously focused on anything. The DMN is where mind-wandering happens. Where memories cross-reference each other. Where ideas that have been sitting in separate folders inside your head finally bump into each other.

When you sit at a desk and force yourself to concentrate, you suppress the DMN. When you walk at a natural pace, the executive part of your brain gets just busy enough handling the walking that the DMN comes online and starts doing the work that focus was blocking.

The most useful finding in the entire paper is the one almost nobody quotes. The boost did not turn off the moment people stopped walking. Participants who walked first and then sat back down stayed elevated. Their next round of seated creativity work was still significantly better than people who had been sitting the whole time. The rest lingered for at least several minutes after the legs stopped moving.

You do not need to do creative work while walking. You need to walk before the creative work. The brain holds the state.

My stepmother did NOT like the way her Libertarian Viking Neighbor framed pregnancy as the fetus "attacking the woman". She incredulously told him this was extremely disrespectful to expectant mothers to portray pregnancy as so violent and negative.

Libertarian Viking Neighbor's response was that people consensually hurt each other all the time, and "there's like a whole community about that, with the acronym the one that starts with a B" And his reasoning was that if the mother was consenting to bring attacked by the baby, it in fact wasn't violent and negative because there was consent.