I'm actually from Baltimost, Merrierland so forgive me if I'm less than impressed
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I'm actually from Baltimost, Merrierland so forgive me if I'm less than impressed

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Probably more medical detail than opsec calls for, but there's practically zero research on nonbinary chemical gender transition — so I'm throwing my trip report into the collective 'net.
I am nearly 29, knew I was trans since 17 and I have been on HRT (estrogen) on and off for the past 18 months with testosterone for the last 6. Currently: 8mg Estradiol Enanthate weekly, plus 25mg testosterone weekly.
The hypothesis: The body auto-converts excess T→E and excess E→T, so it can handle high levels of both without much trouble. Women regularly take testosterone during menopause — this should be doable.
My theory: Take high E to block natural T production, then supplement a tiny bit of T to compensate. Should keep everything contextually balanced.
Six months in, and I just got my labs back. My doctor (not amused by this experiment) is shocked: I'm healthier than I've ever been across every metabolic marker. Dead center on every single metric. Blood pressure normal (first time ever). Weight stable. I have some breast growth starting, but no solidified nodules — so with raloxifene I could revert 90%+ if I wanted (TBD). They are very sensitive, for better or worse.
I have noticed my body becoming more feminine (appreciated), which is saying something since I am naturally broad and muscular. Think of a very masc blacksmith-NPC-character-model kind of build. I have curves now. Skin is overall softer. Body hair is much thinner (previously was bold, black, and gnarly). Face is smoother, jawline more defined, but the face itself is a bit rounder, especially in the cheeks.
Mental state is solid. Making real progress on projects, feeling hopeful, taking more risks and actually being comfortable with it. More open, more outgoing. Before this was quite depressed, anxious, paranoid, unable to make decisions, and just felt worthless, now its the exact opposite - I have tried every anti-depressant around, and had great luck with LSD, but this has been by far the most 'calm', happy, and level-headed I have ever been. That said, on pure estrogen, my mental clarity is certainly sharper. The combo is still clear enough though.
I understand why most queer people hate these kinds of reports (archived) and this kind of experimentation, trust me my friends make that very clear. And sure, I'm probably still denying plenty of things to myself. But , from a research perspective, this has always fascinated me, and the literature is so thin that I might as well add a small, informal case study to the mix.
One thing that worries me about the use of AI is whether or not it can worsen people's dementia and alzheimer's in the future. When my grandmother was first diagnosed, we got her math activity books. Now, my grandmother never had a formal education, but we did our best to keep her sharp, get her to do math and writing activity books, sudokus, playing board games that required some level of strategizing with her. Her family is prone to alzheimer's and dementia (both her siblings had it and deteriorated very very very quickly, which yeah, scares the shit out of me being her granddaughter) but she was the one whose mind lasted the longest, she only passed away two years ago, at 88, ten whole years after her initial diagnosis and sure, she had forgotten things, recipes and where she put her glasses and appointments, but she never forgot any of us, ten whole years in, she still remembered us. Now, this may have been luck, but doctors always said the constant mental work + companionship + medicine helped her a lot. So I'm thinking, these people who are now relying on AI for everything, from email-writing to thinking what's for dinner to casual conversations, I've even seen people rely on it to calculate what time they should leave their house if they need to be at a place at a specific time and their commute lasts X number of minutes. As if that's not... the simplest math operation possible? You shouldn't even need a calculator for that!!! Idk I don't know how long it'll take us to see the effects of this + exposure to brain-rotting short form content that is completely meaningless + people addicted to right-wing conspiracy style media. Idk I'm very worried. Please, read, read complicated books! Take up a book on philosophy and try to decipher it and make your own opinions on it, please buy a maths activity book and relearn how to do math, please get a hobby that involves lots of thinking and concentrating. PLEASE!!!
As a neurologist, I’ll give you the pretty name for it: cognitive reserve.
The way I explain it to my patients is that our neurons don’t regenerate. They make connections with each other and that’s it. If you don’t use your brain, they make fewer connections and, if one of them dies, you’re gonna miss it, because that was the only one that knew how to do X. Now, if each one of them has many, many connections, you won’t notice the difference when one of them dies. The others pick up the slack.
As of 2024, 45% of dementia risk factors are modifiable. Relevant to this conversation, 5% for less education and 5% for social isolation.
We absolutely are going to see the reflection of this, but it’s gonna take decades and it’ll be too late. So, for the love of your brain, pretend that it’s a muscle and make it work. People complain about “when am I ever gonna use this maths formula in my life?” You’re not. You’re teaching your brain to think logically. Those sinapses will be there for when you need to figure out your week’s schedule. English classes taught me how to interpret data and how to convey it in this text so it’s clear and you understand what I’m saying, not because I needed to justify why the curtain is blue.
Make your brain know how to do different things. Logic games, puzzles, taking care of a garden even if small, planning a church’s event or birthday, learn a new instrument, learn a few words in another language, look at a calendar every day, do some manual labor if possible. Do not, I repeat, do not let your brain get rid of sinapses by letting AI do everything. Your brain uses 20% of your body’s energy — do you really think it’s going to maintain connexions that aren’t in use?
Most cases of Alzheimer’s are sporadic, meaning no family history. Family history of a first-degree relative with Alzheimer’s starting before they were 80yo increases your risk in 2-3x on average.
TLDR: Yes. From the knowledge we have today, AI will increase the number and severity of dementia cases.
(via bsky)
In case anyone hasn't heard, the cyclospora outbreak affecting tons of people in the US right now is coming from Taylor Farms produce. Best to stay away from bagged lettuce and prepared salads completely right now, but especially the ones mentioned in the screenshot:
Taylor Farms Earthbound Farms Little Salad Bar (Aldi) Marketside (Walmart) Kroger House Brand Target private label greens Costco salads and greens etc Trader Joe's chopped salad kits and fresh produce Fast food: McDonalds, Taco Bell, (Yum! Brands), Chipotle, Subway, Pizza Hut, KFC, Olive Garden, Top Golf, Red Lobster, Burger King, etc.
This is not the first time I've heard about a Taylor Farms foodborne illness outbreak. I stopped eating their salads after reading a description of the conditions in their facilities. Doesn't sound like they've improved anything.
We need a fully funded and staffed FDA, and regulations with teeth - and that's exactly what we don't have under Trump. To make things worse, the CDC is no longer tracking these outbreaks. We're on our own.

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Tbt my laptop 😭
there's nothing i like more as a computer program than a long period of silent contemplation - not doing anything, not rushing anywhere, just standing here and enjoying this moment with the user. oh, it seems once again he has summoned my beautiful and ruthless wife Task Manager. hello, my darling! what are you doing with that long cruel scimitar
a picture that’s worth a thousand words

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its not funny but i do think about it a lot
This made me think about this panel from Calvin and Hobbes:
But unlike the adult in this strip, Calvin’s dad actually APOLOGIZED for yelling at him when he saw how guilty his kid was:
Polycules should be able to trade people like sports teams do
Listen -- you're a good defender and your pussy is fantastic, but that's not what our team needs right now. We're trading you to Greater Boston in exchange for someone who has a car.
Which notorious English class short story fucked you up the most?
* I Have No Mouth and I Must Scream
*The King in Yellow
* The Lottery
* The Masque of the Red Death
* The Monkey’s Paw
* The Most Dangerous Game
* The Nameless City
* The Ones Who Walk Away from Omelas
* There Will Come Soft Rains
*The Yellow Wallpaper
* The Veldt
* “you think those were fucked up? What about [X]!”
Which notorious English class short story fucked you up the most?
I Have No Mouth and I Must Scream
The King in Yellow
The Lottery
The Masque of the Red Death
The Monkey’s Paw
The Most Dangerous Game
The Nameless City
The Ones Who Walk Away from Omelas
There Will Come Soft Rains
The Yellow Wallpaper
The Veldt
“you think those were fucked up? What about [X]!”
Okay I have things I should be seeing to but I couldn't help myself. In case you, like me, have not read all of these stories and would like to be amongst the lucky 10,000 today:
I Have No Mouth and I Must Scream by Harlan Ellison
The King in Yellow by Robert W Chambers*
The Lottery by Shirley Jackson**
The Masque of the Red Death by Edgar Allan Poe
The Monkey's Paw by W.W. Jacobs
The Most Dangerous Game by Richard O'Connell
The Nameless City by HP Lovecraft
The Ones Who Walk Away From Omelas by Ursula K LeGuin
There Will Come Soft Rains by Ray Bradbury
The Yellow Wallpaper by Charlotte Perkins Gilman
The Veldt by Ray Bradbury
Honorable Mention from the comments/reblogs:
All Summer in a Day by Ray Bradbury
*note: this is actually a collection of short stories and clocks in at about 72k words
**Originally published in the New Yorker in 1948; interestingly, the New Yorker still has this story archived on their website BEHIND A PAYWALL. CAN YOU IMAGINE.
my life with ADHD
This is very true and a great post.
But low key makes me think about how people with adhd have been raised their whole lives to value a day based on what they accomplished vs what they experienced
I think your point is excellent. But also consider:
That list might say things like “Paint a picture. Go birdwatching. Finish that great novel I started reading. Call my grandma. Learn to bake a cake. Visit my sister. Play piano.”
For me at least, the good/fun things are harder without meds too. I can have the best intentions, but following through is hard.
This addition is so important.
Yeah. I once made a post in which I complained about being frustrated at my brain, and one of the things I said was:
“I should not be struggling this much to do things that I want to do and have the time, space, energy, and skills to do. Actually, when I list it all out like that, I should not be struggling at all to do those kinds of tasks.”
And I STILL somehow got a rant about capitalism in the comments. And I do understand where it’s coming from, yes, but goddamn did I not make myself clear? Did I not say Things That I Want To Do???
need to beam this tweet directly into everyone's minds right now

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Unlicensed mug sold in Chinatown Square in Chicago.
Source: Reddit user bfgarzilla9k
there's this weird thing people fall into online a lot, where people assume that if the [perceived-to-be-inferior] version of [activity] is discouraged then people will, naturally, do [perceived-to-be-superior] version of [activity] instead. When really it's just as (or more) likely that if [perceived-to-be-inferior] version of [activity] is discouraged people just won't do it at all.
audiobook listeners are not necessarily people who would otherwise do a lot of traditional reading if audiobooks did not exist, many are people who simply would experience zero books. Booktok romance readers would not necessarily be reading the classics if booktok did not exist, many of them would simply not read. Fanfiction writers would not necessarily be novelists if fanfic wasn't an option, many would just be people who didn't write. You know?