Bico's Place

turns out his princess is a lesbian and nobody knew, so when i cast the spell it made him into a beautiful princess. she asked for a refund right away and begged me (cryin', held me at swordpoint) to turn her back, but i says to her, i says, "The die has already been cast, and your fate is now sealed!" which is my way of sayin' "no refunds".

turns out, bein' a princess weren't so bad for her and she was able to take her sweet and beloved princess' hand in marriage. seems like everything worked out.

but then, surprise of my life, they both show up to my tower and my spell was undone. some dark sorcerer shithead (some kinda sketchy royal adviser who wanted to usurp the throne, a million like 'im) had removed my enchantments and turned our princess back into a knight. but she didn't want to be a man no more and asked me to redo the spell. gladly i changed her back in exchange for fuckin' up this sorcerer shmuck, (could be a threat to my business, you see) gave 'er an enchanted sword an everything. to my shock, the other princess takes the sword and vows to get this guy for me.

now i got all this guy's magic shit and good graces for life with the queens of the land, plus the best advertisement money can't buy. "yes, i am in fact That wizard from the story of the princess knight!" classic.

Mexico amends its constitution to cut the maximum workweek from 48 to 40 hours by 2030 and gives 13.5 million workers the legal right to ignore their boss’s calls, messages, and emails after their shift ends, in the most significant overhaul of Mexican labor law in a generation.

Full Transcript at the link; 3-minute listen.

Quote:

By taking biopsies from long COVID patients before and after exercising, scientists in the Netherlands constructed a startling picture of widespread abnormalities in muscle tissue that may explain this severe reaction to physical activity.

Among the most striking findings were clear signs that the cellular power plants, the mitochondria, are compromised and the tissue starved for energy.

"We saw this immediately and it's very profound," says Braeden Charlton, one of the study's authors at Vrije University in Amsterdam.

The tissue samples from long COVID patients also revealed severe muscle damage, a disturbed immune response, and a buildup of microclots.

This article mentions that ME/CFS is a "similar complex condition" but that's DEEPLY underreporting the similarities. The phrase "post exertional malaise" (now researchers are trying to replace it but this article uses that phrase) was INVENTED for ME/CFS. It's the only known condition, before "long covid", that causes these kinds of symptoms after exertion!

It's good to know for sure that it's the same mechanisms at play when the inciting viral infection is Covid and not, for instance, Epstein-Barr or RSV, but half the time it doesn't seem like researchers are making comparisons at all, just reinventing the wheel and acting like "long covid" is a totally new phenomenon with no previous point of comparison. There are literally drugs in human trials to try to treat the mitochondrial dysfunction in ME, this dysfunction is well-established and fairly well understood and I feel insane when ppl report on long covid without mentioning that there is already a named and studied condition that accounts for this subset of symptoms!!

SOME researchers are drawing comparisons but they're largely ME researchers who everyone else is largely cignoring because of the widespread perception that ME is a fake disease for lazy women.

That same perception btw is why "graded exercise therapy" (GET), or exercise gradually increasing in intensity, cwas for years the go-to treatment despite MOUNTAINS of evidence that it makes ME patients sicker. Some end up permanently bedbound and unable to even eat or drink without a feeding tube/IV because the damage is so bad! The GET recommendation was finally changed only in the past few years in the US and the UK, and many doctors hate that they're not allowed to recommend it anymore, because they insist despite the evidence that ME/CFS is psychological and ME patients are just "deconditioned" and too lazy to do anything about it.

Now the same kind of "treatment" is being recommended for long covid patients despite evidence showing exercise is having the same kinds of cellular effects as it does in ME patients. "Taking PEM into account" sounds gentler but I'm deeply concerned about the reinvention of GET for patients who meet all the criteria for an illness that's been shown definitively to become permanently worse with GET. This mitochondrial damage is progressive in ME, and there's no reason to believe patients who meet all the criteria of ME after Covid won't experience the same progression if they force themselves past their energy envelope in such a systematic way.

The additional finding that T cells — part of the immune system's arsenal — had infiltrated the muscles of long COVID patients also caught Iwasaki's attention, possibly indicating "an autoimmune response within the muscle cells."