Anyway I don't need to justify myself to anyone. In my post-canon freak4freak Destiel House MD casefic the poisoning revelation rather than being the conclusion is the mid-episode red herring. Deanna vehemently denies poisoning her husband and is deeply offended by the accusation but when this is revealed to Cas he says "Oh do you think that's the problem? 🤔 Usually when she poisons me I am only sick for a few days..." Because he knows that Deanna poisons him sometimes when she gets anxious about him leaving and he enjoys it because it means she dotes on him for a few days and it reminds him how much she loves him. Deanna is deeply touched to learn this and everyone is increasingly concerned about their relationship except for House who started the episode trying to prove they don't really love each other and now thinks that they're made for each other.

Obviously a large part of the appeal to me is the large cast of characters to give outsider POV opinions to and the benefit of using the House MD cast for this is that they are all massive dicks. Everyone has an opinion on the Destiel relationship and most of them are bad. House as I have mentioned starts out trying to prove they can't possibly be as in love as they seem, this is in part because Wilson keeps insisting that they have a nice thing going and can't we just believe that people love each other? They actually make him kind of uncomfortable but he doesn't want to say that. Then House switches sides because "They're both insane, in perfectly matching ways, and they found each other. Which keeps them from inflicting their wackadoo on the rest of us. It almost makes you believe in soulmates." And Wilson is like "Stop agreeing with me" but he can't switch sides now without looking like a hypocrite.