(as of 3/28/2018, paper was published in the reputable international research journalĀ āNatureā on 3/27/2018, publication here, study was started in 2013) ok so like uhhh this is my rough translation of the paper they published using my current level of biological knowledge, if anyone else has a more in depth understanding with human anatomy things and would like to add on with anything i might have missed feel free to add but this is my takeaway:Ā
-scientists were looking at some stuff in the inside of a bile duct they were studying in a live patient (this will be important later) using a laser that lets them see the cells in real time. they injected some stuff into the duct and saw the spaces inbetween the cells fill up with fluid in strange, tube-like structures that didnāt correspond with what they expected to be there, so they sectioned and froze them to study them closer; they realized that upon closer inspection, the fluid-filled places were VERY small collagen tubes forming a complex matrix of bundles surrounded by a weird cell covering that seemed to connect them to one another. they called this the Interstitium.Ā
-they sectioned some more places where squeezy things might happen, like the inner linings of the bladder, lungs, lymph nodes, and the soft tissue enclosing our muscles, filled them with the same indicator, and hyper froze them like they did to the first sample and found the same weird matrix of fluid-filled tubing:
they concluded from what they found from this that:Ā
1. our previous thought of the space inbetween the cells in these parts of the body, which we thought were just kinda like, there or whatever doing nothing (a series of spaces that were already called the Interstitium that were largely ignored), are actually full of complex tubing running through a ton of very important parts of your body
2. when the structures theyāre chilling around (like your bladder and bowel) contract, the fluid moves around all weird
3. the reason this wasnāt discovered before is because when the tubes are squished too hard- like when scientists are cutting into them- they have a tendency to collapse really easily, especially when being treated with chemicals for microscope use, giving the impression of the kind of tissues that weāve traditionally seen in specimens and thought of being in these sensitive areas (closely compact and dense cell mats). it turns out that in living people, these tubes run between the cells carrying fluid; the scientists were able to see this initially in live patients using the above mentioned laser technology, and then took live biopsies by quickly freezing the cells in place before removal to prevent their collapse.
4. yes, these can move cancer cells around, which is HUGE seeing as they seem to enclose a LOT of important and delicate muscles in our bodies in one giant, complex system. when they looked at it in cancer patients, the tumors they found seemed to kind of beā¦.leakingā¦.into themā¦..because the tumors were putting pressure on the fluid tubesā¦.which easily collapseā¦..and move things that fall into the fluid aroundā¦.
5. the scientists also explored things like hernias and colon damage in relation to these, but unfortunately this is where my translation powers run out as non-plant-related terminology starts being used lmao im so sorry im like this
tl;dr: the membranes that surround some really important parts of squishy things like our stomach, bowels, colon, lungs, muscles, etc are full of very delicate and complex tubing that runs in a weirdly complex system to other important squishy things throughout our bodies and looks like a weird organ that we didnāt know was there before (or like, we knew about it, we just didnāt know it was soā¦connected and uhā¦organy). also it seems to have an impact on the spread of cancer throughout these regions
hereās the paper again if you want to have a read and see pics of the tubing itself and draw more in depth conclusions from it lmaoĀ
