#entosis

LBH is a neoplasm (tumor/cancer), he escapes death and has, for some reason, found a way to escape any forms of induced dead. (So he can't be killed by other cells nor the narrative.)

PIDW SJ is anoikis, he dies because there are no other cells around him that tell him to live. His conection with YQY is severed, and as its the main source of his signal to keep living, he comits apoptosis.

PIDW YQY is necrosis. he dies due to external damage, and his death isn't clean, infecting neighbouring tissue and causing more death in its wake. He would like to be apoptosis, he thinks he is apoptosis (a very organised way to die) but he is not. His death is messy and infects everything it touches.

PIDW NYY is apoptosis. She grows into a very good, meek woman, and in LBG's harem, she shrinks into herself and as she's obedient, if you tell her to, she would die in a very clean and orderly way, not causing many issues.

PIDW Haitang is also apoptosis. Her death wouldn't be loud, even if she would fight it more. She cannot bear the metabolites that have accumulated in her, she cannot bear the errors, and dies.

SVSS Haitang, though, is autophagy. Autophagy in cells is also associated with stress and neurodegenerative diseases. She realizes that there was osmething poisonous she didn't prevent, and she goes insane, her mind devouring herself and leading her towards death.

PIDW LQG is mitotic catastrophe. He notices that something went wrong, and if he doesnt die he will endanger others. Therefore he stops himself and kills himself. Just like cells noticing their mitosis is going wrong.

SJ in SVSS is autophagy - he dies, but his body is repurposed and reused by the body (the narrative), as everything he left enough got broken down and made into usable blocks with which to build new cells (SY's future.)

GYX - Fas Ligand induced death, he had to die for thr sake of the plot (the body narrative had to have him killed)

SXY is entosis. Another cell developed inside of her, and thus she the cell inside of her should have been killed by her organism (or OPM's poison). She sacrificed herself so that the internal cell could survive.

TLJ is pyroptosis, he is killed by inflammation (being attacked by righteous cultivators, then shackled). His new body is rejecting him, inflamation is making him disintegrate.

SY is parthanatos - his body accumulates qi (apoptosis inducing factors from the mitochondrium) and he dies due to overabundance of it. (Shizun explosion.)

The Devour Ring

In this act of microscopic cannibalism, known as entosis, one human cell engulfs another. A bit like a snake dislocating its jaw to eat a mouse (although 2000 times smaller) the predatory cell (on the left in these pictures) opens up its cytoplasm, forming a ring shape, pictured in 3D on the top row and in cross section beneath. Scientists find this ‘mechanical ring’ is riddled with a mechanical sensor called vinculin, and expands by coordinating stretchy actomyosin in the cells’ membranes at the adherens junction – the boundary where cells touch. The engulfed cell usually dies, so entosis is often considered a mysterious form of programmed cell death. Learning more about the ring, and how it forms, might offer clues into slowing cancer progression, where tumour cells sometimes use entosis to consume surrounding healthy tissue.

Written by John Ankers

Image from work by Manna Wang, Zubiao Niu and Hongquan Qin, and colleagues

Laboratory of Cell Engineering, Institute of Biotechnology, Beijing, China

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Cell Reports, August 2020