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Antioxidants Illuminate Ferroptosis
For decades, we’ve understood cellular death through a few well-defined mechanisms, but what if there was another player on the stage, operating in the shadows? A groundbreaking discovery is rewriting our understanding of how cells expire, revealing a previously unknown form of regulated cell death with potentially massive implications for human health. Scientists have unearthed compelling…
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The Scientific Research Notes Of S. Sunkavally (years: 2002-2011).
3097-3098.
2,3,5–tris-(Glutathion-S-yl)hydroquinone (TGHQ) is a reactive oxygen species (ROS) generating metabolite of the nephotoxicant, hydroquinone. In renal proximal tubule epithelial cells (LLC-PK1), TGHQ catalyzes the formation of single strand breaks in DNA, followed by growth arrest and oncotic/necrotic death during the cell cycle. Treatment of synchronized LLC-PK1 cells with TGHQ causes an initial decrease in the expression of the DNA damage inducible protein kinase chk1. The degradation of chk1 in highly synchronized LLC-PK1 cells might induce mitotic catastrophe, a potential mechanism of cell death in this model.
Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis
Broadfield, L. A., Pane, A. A., Talebi, A., Swinnen, J. V. & Fendt, S.-M. Lipid metabolism in cancer: new perspectives and emerging mechanisms. Dev. Cell 56, 1363–1393 (2021). Article CAS PubMed Google Scholar Riscal, R. et al. Cholesterol auxotrophy as a targetable vulnerability in clear cell renal cell carcinoma. Cancer Discov. 11, 3106–3125 (2021). Article CAS PubMed PubMed…
Azoles Trigger Programmed Cell Death in Crop Pathogenic Fungi
Key Takeaways Dual Pathway Activation: Azoles activate both apoptosis and macroautophagy in fungal pathogens. Impact on Plasma Membrane: These fungicides reduce membrane fluidity without compromising integrity. Mechanism of Action: The action impairs F-BAR proteins, leading to defective septation. Broad Implications: Findings apply to various ergosterol biosynthesis inhibitors, influencing…
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There are over 10 different ways cells can “decide” to die, each serving a particular purpose for the organism.
Programmed cell death can be broadly divided into two types that are crucial to health: silent and inflammatory.
Cells can often become damaged because of age, stress or injury, and these abnormal cells can make you sick. Your body runs a tight ship, and when cells step out of line, they must be quietly eliminated before they overgrow into tumors or cause unnecessary inflammation where your immune system is activated and causes fever, swelling, redness and pain.
Your cells die to keep you alive. Cell death does everything from fighting cancer cells and pathogens to forming your fingers and toes.
Cell injury and death
The Component of cell undergoes a variety of changes responding to cell injury, and may or may not lead to cell death.
The Component of cell undergoes a variety of changes responding to cell injury, and may or may not lead to cell death. Cell injury and death .pdfDownload Injurious stimuli trigger the process of cellular adaptation, whereby cells respond to withstand the harmful changes in their environment. Overwhelmed adaptive mechanisms lead to cell injury. Mild stimuli produce reversible injury. If the…
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PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest. Yuan, et al., Nature communications doi: 10.1038/s41467-022-32976-9.
Cytoscape cited!
