When in doubt, talk to your prescribing physician. Then, if still in doubt, talk to your pharmacist.
Be aware that a lot of this stuff is 1. Still actively being studied; and 2. Dependent on a variety of factors, including dosages and genetics.
Also, neutralize is a rather hyperbolic choice of word. Current studies indicate that some fruits and fruit juices can reduce the efficacy of certain drugs. Also for some drugs it actually causes an inverse reaction where it results in too much of the drug entering the bloodstream, thereby causing toxicity.
By FDA graphic by Michael J. Ermarth - Author; Kaidor - Vectorization. - Own work based on: Grapefruit Juice and Medicine May Not Mix, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=122098363
(Yes the above image is about grapefruit juice. Grapefruit happens to be the fruit this interaction was first discovered with and the one currently most studied.)
To suggest that a glass of orange juice can completely negate the affects of stimulant medication is disingenuous at best and downright misinformation at worst. It’d be more accurate to say that taking your meds with orange juice might make them less effective, thereby necessitating a higher dose for an equivalent effect than if you only ever drank water.
Finally, nothing I have found indicates it is the citric acid causing this effect. It seems to be a completely unrelated type of molecule, enzymes called furanocoumarins. These enzymes seem to bind to certain enzymes in the liver and/or intestines (Cytochrome P450) which in turn can — again, increase or decrease depending on the drug — affect how readily some medications are absorbed into the body.
That said, I’m no chemist, much less a doctor. Frankly a lot of the technical and detailed scientific explanations sailed right over my head. Bringing us back to the original point.
TL;DR - Talk to the people prescribing your medications and/or the people filling those prescriptions about any concerns you have about potential interactions between different drugs, your diet, or other lifestyle factors you suspect could be having an effect.
Anyone on the internet could be wrong, lying, or trying to sell you something. Especially so on one of the last remaining websites with any sense of anonymity. Double especially so in this, the era of AI slop.
Please talk to a real person in real life about this stuff.
Your health and molecules are too important not to seek out the best, most credible sources of information available to you. And if you’re taking ADHD meds, you definitely have a prescribing doctor who you are already paying (or paying the insurance to pay) to ask these questions to.
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