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i go to the shop and I ask if they have any raspberries. they say no, they used to sell raspberries, but they haven't had any in stock in the last 15 years. I ask if there's somewhere else I can go to buy raspberries. They say no, with confidence and pride, they're the only shop around who has ever sold or will ever sell raspberries. Other shops might sell other fruit, sure, but they have a monopoly on all raspberries forever. I ask if they're possibly planning on them selling them again in future? they say they can't tell me that.
on the way home, I encounter someone eating raspberries. I ask and they tell me that they grow their own, they got some seeds from the shop back in The Raspberry Days and kept them. They take me to a field of many beautiful raspberry plants and invite me to pick my own, they're free for all the town to pick whenever they'd like.
someone comes up behind us. It's the shop manager, President of Nintendo Shuntaro Furukawa. he hatefully throws a bob-omb that blows up and kills both of us instantly for stealing 200 trillion dollars worth of potential Raspberry Shop That Doesn't Do Raspberries Anymore profits that they weren't making and then he turns around to the camera with a big thumbs up and says don't do piracy or something ok please
Two years ago, the occupation destroyed our home, turning our dreams, memories, and everything we owned into piles of rubble and ash, as seen in this picture.
Since that day, my family and I have been living in a tattered tent that offers no protection from the bitter cold of winter or the scorching heat of summer. Two years of continuous suffering under this worn-out fabric that neither shelters our bodies nor provides any shelter for our family. Today, I appeal to you with all my pain and suffering, asking for your support and assistance so that we can repair our tent and obtain food and water. I hope you will stand with us and not ignore us, friends.
Please help us through this ordeal and live a dignified life.Your support will make a huge difference in our lives and help us persevere and secure the most basic necessities and warmth for my family. Please don't leave us alone.
My friend Ahmed has been enduring unthinkable conditions. He has gone without clean water and nutritious food for long periods. He has become severely anemic and made dizzy with hunger. He is suffering in the heat in a densely populated refugee camp, afraid of bombings that could come at any time. Ahmed deserves love and support. Please help him!
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sometimes the stone fruit is just okay. even in june. but the key is not to panic. you have to take the stone fruit, you have to cut it, and you have to fry it in a pan with some sesame oil until it's got just a patch or two of brown on it. then it's the best yellow peach you've ever had in your life and everything will be okay
they really don't respect the time of disabled people. your application can take up to 12 weeks. the specialist waitlist is 3 years. your assessment will be any time within the next 6 months. let us know if you cannot attend this appointment you waited 7 weeks for and we'll reschedule next year. we've decided to assess you at this time and day and you have to be available or any support you dared to apply for is not going to happen. and in between these long bouts of waiting you have to survive the everyday
eating disorders and abortions are two things that are like, spoken about in most mainstream discourse as though they are pretty rare and aberrant, but then when you’re actually friends with a lot of women you come to find out that they are extremely extremely common and kind of banal & mundane
Researchers at the Federal University of São Paulo (UNIFESP) in Brazil have discovered that SARS-CoV-2, the virus that causes COVID-19, uses
Researchers at the Federal University of São Paulo (UNIFESP) in Brazil have discovered that SARS-CoV-2, the virus that causes COVID-19, uses a sophisticated tactic to evade the human body's defense system. In addition to its ability to evade the immune system before invading the host cell, which is common to other viruses, SARS-CoV-2 acts on a second front by manipulating the host cell's genetic material in a way never before seen in other pathogens.
The study, published in the journal Nucleic Acids Research Molecular Medicine and supported by FAPESP through a Thematic Project and a postdoctoral fellowship , describes how the virus interacts with the RNA of infected lung cells in an unprecedented way.
"SARS-CoV-2 doesn't mess around. It interacts with the host cell in an extremely sophisticated and direct manner, manipulating its genetic material like no other pathogen does. We discovered that, through a very sophisticated pairing mechanism, the virus's RNA interacts with different types of RNA in the infected cell, interfering with the functioning of the cellular machinery and blocking the production of interferon, one of the main antiviral defenses," explains Marcelo Briones , coordinator of the Center for Medical Bioinformatics at the São Paulo Medical School (EPM-UNIFESP) and coordinator of the research.
According to Briones, although this is a fundamental biology study, the discovery may influence our understanding of the disease and the development of vaccines and treatments in the future. "This changes our understanding of the virus and of RNA viruses and paves the way for new prevention and treatment strategies. We've shown that SARS-CoV-2 protects itself through methylation, that is, by modifying its RNA with a methyl group. In theory, this could enable the development of antivirals that inhibit the enzymes responsible for this RNA modification," Briones explains to Agência FAPESP.
Weakened immune response
SARS-CoV-2 is an RNA virus, meaning it does not have a DNA genome, and it has a high capacity for mutation. "This doesn't mean that they're simpler viruses; quite the contrary. Our study showed that RNAs interact with both invading virus molecules and molecules that are extremely important for the immune response, which is extremely interesting from a fundamental biology point of view," he says.
In their work, Cristina Peter and Caio Cyrino identified that SARS-CoV-2 exposes its RNA to the cellular environment as soon as it penetrates cells, promoting connections with a specific type of RNA – long non-coding RNAs (lncRNAs) – to circumvent the initial immune response of human cells. The virus quickly establishes connections with lncRNAs, such as UCA1, GAS5, and NORAD, upon invading the cell. These lncRNAs are important regulators of interferon signaling, which is a key component of innate antiviral defense.
During this process, a chemical modification occurs that the scientists call N⁶-methyladenosine (m⁶A) methylation. This process destabilizes RNA structures and hinders the classic pairing between the amino acid bases adenine (A) and uracil (U). "Our main hypothesis is that methylation destabilizes double-stranded RNA structures, promoting Hoogsteen-type pairings, which are less stable and can interfere with interactions between RNAs and, consequently, with interferon signaling, which impairs the immune response," Briones explains.
He adds that this structural change reduces the binding time of lncRNAs to their main targets, such as microRNAs (miRNAs), thereby weakening their regulatory function. "In the study, we identified the lncRNA UCA1 as a central player exhibiting a complex pattern of reduced expression and increased methylation. It interacts directly with both the viral genome and components of the interferon pathway," the researcher explains.
The study used Oxford Nanopore sequencing technology, which allows for the direct, real-time analysis of long fragments of RNA or DNA. This technology works by monitoring changes in an electric current as nucleic acids – the molecules that make up genetic material – pass through a protein nanopore. The resulting signal is decoded to determine the specific RNA sequence.
This result can then be immediately compared to a genetic sequencing database to identify various pieces of information, such as the species to which the material being studied corresponds. Using machine learning techniques, the researchers measured the overall increase in methylation in cells. Mathematician Fernando Antoneli and Nilmar Moretti participated in the work.
Briones says that the next steps will be to validate the computational analysis data experimentally. "Now the bench work begins to confirm the mechanisms we observed," the researcher concludes.
About São Paulo Research Foundation (FAPESP)
The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at www.fapesp.br/en and visit FAPESP news agency at www.agencia.fapesp.br/en to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at http://agencia.fapesp.br/subscribe .
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As much as I talk shit about my home state, if I had to rate US states by the sheer ambient evilness and how much I hate them it would undoubtably be
1. Idaho
2. Florida
3. Ohio
Coming from a state that borders Idaho, I can count the number of people I’ve met from (not moved to as an adult) Idaho who weren’t like Deeply Horrible people after longer than a single conversation of knowing them on one hand.
It is a corrupting force that taints the heart of those who stay too long in it and drives them to cause suffering to those around them. It’s also a large Mormon stronghold. Nothing good comes from Idaho but potatoes.
Expanding on tags I wrote a bit ago, I was going to add what I could recall about the racist history of the NW and Idaho in particular, but found a decent wiki article instead:
Literally a neonazi state. Genuinely facist culture.
Also, most potatoes come from Maine at this point.
I say this all the time. Idaho is closer to Nazi Germany than anyone realizes, like everyone there is a weird racist cultist, or just an open Nazi. We had this nurse who's husband went to visit his family in Idaho, he came back and was obsessed with them moving there with their three kids to be raised in some weird cult, like to the point he sold their house out from under them, and she had to get a divorce and a restraining order cuz he kept trying to steal their kids. He ended up going alone, and three years later, he had a new wife and 4 more kids. They lived in an underground shelter
Being a calm, gentle, non-reactive person is really hard work, which is probably why many people are none of these things. Personally I think it’s worth it but sometimes one does want to just roll around on the floor wailing at the top of one’s lungs
People in my notes who think I’m repressed or dissociating: you will feel better when you learn emotions are not a binary of Not Feeling It vs Being Overwhelmed By It
So my FIRST piece of information if you’re still a teen is that genuinely as you get older it will get easier to regulate your emotions. During adolescence our brains are undergoing a lot of growth and change that genuinely does make it harder to do this, on a scientific level. However, practicing emotional regulation skills can still help a lot and if you can find something that works it will make life easier going forward
This page has more information and recommendations for some basic exercises:
Discover effective strategies for teens to manage intense emotions, develop emotional awareness, and improve overall well-being. Expert tips
i'm heating up some old ass nachos here but i rewatched season one and what's crazy about all the misogyny is that trinity is like... medium mean to the people around her. it's really not that bad lol. yeah, shitty nicknames, does things without asking; the men on the show have and will do worse. and all of her kind moments make up for it. genuinely, you watch any episode and you will see that she has moments where she cares, asks if someone is okay, shows support through a slightly misplaced joke, and much more. the kindness and clear heart she has overshadows it all so badly that it's crazy how many people just deliberately hate her lol. especially since all her 'bad' behavior is justified and settled within the show.
I do really love it when women write graphic and fucked up things. I feel like so often people react to fucked up fiction with “of course a disgusting man would write this 🙄” and it often carries an unspoken (honestly sometimes spoken) message of “a woman’s PURE and DELICATE and FEMININE mind could NEVER think of something this VILE”. Thank you women in fucked up fiction 🫡
okay this is a list of exclusively bangers, not even counting the fact that WE HEXED THE MOON is on here which obviously makes me feel joyous. but kushiel's dart fuckin RULES as did on sundays she picked flowers and patricia wants to cuddle. 10/10 no notes
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there are a lot of female characters where you can say that lesbian sex would fix them but it's kind of even more fun when it wouldn't. like clearly she wants to be having it but it would make everything worse and ruin her life. and i would like to see it.
Not gonna lie this makes me a bit irritated. Here's the real version of this photo:
Instead of a cutesie reference to film censorship it was an explicit statement of defiance of Maryland's criminalization gay sex, which was not repealed until 2002. This wasn't a guy saying "Oh they can't put what I do in the movies according to a completely voluntary industry code" he was saying "The State of Maryland wants to put me in jail for being gay and having gay sex."
It wasn't a guy being cheeky about sex in an ambiguous, cute way. It was a man stating, in no uncertain terms, that a whole state of the United States considered him a criminal for being homosexual.
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