Product Placement
I'd rather be in outer space 🛸
shark vs the universe
Lint Roller? I Barely Know Her
Love Begins
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#extradirty
Origami Around
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@wisewizardkitty
over the garden wall really just aired its 10 episodes once in 2014 leaving a whole generation with irreversible damage and then fucked off never to be seen again
Have you read the book? I recommend, it's truly emotionally damaging
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ive been reading a book that basically explains how so-called “brain differences” between the genders is the result of gendered socialization and not the cause of it. i honestly expected the book to be very cis-centric but its actually the opposite, the author stresses that testimony from trans ppl is actually indispensable because we’ve, in a sense, “lived both experiences”
more cis feminists should have this mindset
one of the first examples that she uses to introduce her point about how perception by others can shape a person’s performance actually uses a trans woman. it explains that as a certain trans woman became to be seen as a woman more and more frequently, the ppl arond her eventually started viewing her as being ill equipped for tasks that they did not bother her about pre-transition. eventually she even found herself underperforming in these tasks herself.
whats the name of the book
Delusions of Gender by Cordelia Fine
Here’s a pdf, babes <3
I knew it was this book before I’d finished reading the first two lines. Honestly this book is indispensible if you want to debunk any gender determinism people claim is science. I can’t recommend it enough.
She’s written a new one! It won the Royal Society prize for science book of the year, and it’s called Testosterone Rex, and it is excellent.
(Bonus: it’s making old white men really really mad.)
(Bonus bonus: I am myself a neuroscientist, and the old white men mentioned above – who are not – could not have missed the point harder if they’d actively tried. Which. Maybe?)
Thanks to moon-boob for providing a PDF, but please, buy the book if you have the disposable income. SUPPORT THIS AUTHOR!!
The DNA regions in our brain that contribute to make us human
With only 1% difference, the human and chimpanzee protein-coding genomes are remarkably similar. Understanding the biological features that make us human is part of a fascinating and intensely debated line of research. Researchers at SIB and the University of Lausanne have developed a new approach to pinpoint, for the first time, adaptive human-specific changes in the way genes are regulated in the brain. These results open new perspectives in the study of human evolution, developmental biology and neurosciences. The paper is published in Science Advances.
Gene expression, not gene sequence
To explain what sets human apart from their ape relatives, researchers have long hypothesized that it is not so much the DNA sequence, but rather the regulation of the genes (i.e. when, where and how strongly the gene is expressed), that plays the key role. However, precisely pinpointing the regulatory elements which act as ‘gene dimmers’ and are positively selected is a challenging task that has thus far defeated researchers.
Marc Robinson-Rechavi, Group Leader at SIB and study co-author says: “To be able to answer such tantalizing questions, one has to be able identify the parts in the genome that have been under so called ‘positive’ selection. The answer is of great interest in addressing evolutionary questions, but also, ultimately, could help biomedical research as it offers a mechanistic view of how genes function.”
A high proportion of the regulatory elements in the human brain have been positively selected
Researchers at SIB and the University of Lausanne have developed a new method which has enabled them to identify a large set of gene regulatory regions in the brain, selected throughout human evolution. Jialin Liu, Postdoctoral researcher and lead author of the study explains: “We show for the first time that the human brain has experienced a particularly high level of positive selection, as compared to the stomach or heart for instance. This is exciting, because we now have a way to identify genomic regions that might have contributed to the evolution of our cognitive abilities!”
To reach their conclusions, the two researchers combined machine learning models with experimental data on how strongly proteins involved in gene regulation bind to their regulatory sequences in different tissues, and then performed evolutionary comparisons between human, chimpanzee and gorilla. “We now know which are the positively selected regions controlling gene expression in the human brain. And the more we learn about the genes they are controlling, the more complete our understanding of cognition and evolution, and the more scope there will be to act on that understanding.” concludes Marc Robinson-Rechavi.
Positive selection: a hint of the functional relevance of a mutation
Most random genetic mutations neither benefit nor harm an organism: they accumulate at a steady rate that reflects the amount of time that has passed since two living species had a common ancestor. In contrast, an acceleration in that rate in a particular part of the genome can reflect a positive selection for a mutation that helps an organism to survive and reproduce, which makes the mutation more likely to be passed on to future generations. Gene regulatory elements are often only a few nucleotides long, which makes estimating their acceleration rate particularly difficult from a statistical point of view.
Friendly reminder that the reason you feel so much better is because of your meds, don’t stop taking them unless you talk to your doctor first, you really do need them, I promise.
Around June I stopped taking my eye medication because I hadn’t had a problem with my eyes in months. I got really lazy about doing it; then I stopped them altogether.
Turns out, the reason I stopped having problems with my eyes was because I was religiously taking my medication. Whodathunk. Now I have to work to get back to the place I was before I decided I was “better” (I wasn’t!).
If you thought this post was just about anti-depressants or lithium, it could be! For me, this post is about eyedrops, for you it might be about antibiotics, or it might be about zoloft. Whatever it is, please consider talking to your doctor before making a sudden shift to stop taking it. It’s not bad to be on medication. It’s not bad to need it.
…and on a related note, do not let anyone tell you that because you start feeling worse if you don’t take your medication, that means you’re “addicted”. That is not how addiction works.
Okay everyone reblog this version
is there any look hotter than disheveled and slightly bloody
um?? dishevelled and slightly bloody, with a sword under their chin
Ahem. Dishevelled, slightly bloody, with a sword under their chin, while smiling lasciviously
for your consideration: dishevelled, slightly bloody, with a sword under their chin, while smiling lasciviously, and kneeling
I am afraid we are all extremely queer.
Can't y'all just send some pieces of writing of this? Cuz I'm an absolute sucker for these
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Well uh I just want to stop existing please
Well I'm not sure how to ask this (I don't really know who else to ask) but... What does it mean the you feel highly nauseous when you feel like crying so you keep your emotions into yourself hoping one day you can actually acknowledge that it is not your fault you feel that way and you deserve to feel that way???? Pls send help
Y'all of you consciously stop yourself from connecting with people and you're afraid of talking about what makes you feel bad... I think you were a victim of abuse
Don't y'all feel like they have no right to trauma?
Like you know you have it, but you feel like you were too sensitive, or too stupid, or you don't get to say because it is nothing for other people; you feel like you shouldn't have been affected so much and you feel guilty because you feel like you let it impact you so much.
Just me? Okaaay :))
When your dad tries to guilt trip you into visiting him: “well I guess I’ll just spend the weekend all by myself...”
You say “glad to know we’re on the same page.” Slowly, he will have to adapt to just outright telling you what he thinks instead of playing mind games.
When your friend tries to hint that they’re mad at you without saying anything: “Oh, I’m fine, clearly you don’t need to worry about me,”
You say: “I’m glad you’re doing well. Call me if you want to talk, though!” Soon enough, they will accept that they can’t be passive aggressive with you.
When your boyfriend says: “All your friends are great, I really love *insert male friend* especially.”
You say: “I’m so glad you like my friends! I should invite them back soon.” He needs to understand that if he has a problem with your friends, he needs to just voice his concerns instead of being sarcastic and accusatory.
As someone who has lived through several toxic relationships and has an abusive father, I think one of the most important manipulation tools a toxic person has is excessive subtext and hidden meanings in their conversation. It hides all of the actual fighting from the eyes of onlookers while still hurting you, which is scary and makes you feel like you’re making it all up. Don’t put up with this bs. Make them stop hiding.
Make. Them. Say. What. They. Mean.
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in 1994 when green day first became famous, they invited pansy division, an openly gay punk band, to open for them for the entire dookie tour knowing full well the responses would be mixed. in 2016/2017, on their revolution radio tour, green day chose only female led punk bands to open for them to help create recognition for these artists in a male dominated scene. this band has always been using their voices for the right reasons and i love them so much for that.
And Against Me! Is opening for them too! A band fronted by a trans woman! Fuck yeah Green Day
If I’m not mistaken, there was a prom somewhere that was cancelled one time because a lesbian couple wanted to go, so Green Day rented a venue and had a prom for them. Not sure about accuracy, my mom told me about that
yes this is true as well!! green day helped to fund and organize this second prom when the first one was cancelled. the second prom was actually open not only to the students of the school, but also to any other lgbtq+ students as well as supporters in the state of mississippi who wanted to attend as well!!
Billy Joe Armstrong once literally leapt into the crowd at Green Day show and drop-kicked a guy who wouldn’t leave a girl alone.
This exemplifies how do to representation right. Being a straight ally doesn’t mean creating things for LGBT+ people. Its about giving those who are already creating a better stage.
He’s not a “straight ally” he’s bisexual.
He’s not a “straight ally” he’s bisexual.
Fuck Yeah Green Day!
this is so important and nobody is covering it.
U wanna die, arrogant assholes?
so, tumblr gave me the wrong idea about supernatural
SO. DAMN. ACCURATE.
I started the show bcs of tumblr
If your reflection is missing
1. Do not touch the mirror. If you have already touched the mirror, SKIP TO STEP 15 IMMEDIATELY.
2. First, make sure that your reflection is really gone. Make sure that you are visible. If you are not visible, the lack of a reflection is normal.
3. Check another mirror to see if your reflection is there. If so, the mirror without a reflection is simply broken and needs replacement.
If you have confirmed you are visible and your reflection is gone from all mirrors:
4. Do not touch the mirror.
5. Fill a bowl with water. Overnight, leave it at the base of the mirror nearest to your bed.
6. When you wake, if the bowl is empty, your reflection simply has business elsewhere for a while. You may rest knowing your reflection will return when they are ready.
7. If the bowl is still full, your reflection has been taken.
If your reflection is gone:
8. Be ready. They may come for you.
9. Prepare for a journey. With your reflection gone, you may pass through the mirror, but first, be sure you are prepared.
10. Bring food and water. Beyond the mirror, eat or drink nothing unless it has specifically been offered to you. Dying of hunger or thirst is better than the alternative.
11. Tie one end of a ball of string around your ankle, and the other to something on this side of the mirror, like the foot of your bed. This will not help, but sometimes reassurance is necessary.
12. Do not trust what your eyes or ears show you. Count the number and direction of each step you make. Make no marks. Take nothing with you. Leave nothing behind.
13. What state you find your reflection in will vary. I cannot advise you on this. Trust your instinct. Do not trust them.
14. Follow the steps you made back to the mirror. Do not let your reflection ahead of you. They will be grateful for your rescue, but they may still try to leave, trapping you in their place.
IF YOU HAVE ALREADY TOUCHED THE MIRROR:
15. I’m sorry.
16. Try to wash the chrome off your hands. You will not succeed.
17. Wait. Be ready.
18. They are coming for you. There is nothing you can do.
19. I’m sorry.
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How to Sneak Food from the Kitchen at Night
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Emily Carroll
I reblog this every time I see it, because the part that makes this so horrific to me, is that the room is a direct callback to Goodnight Moon. It takes this memory of safety and security and turns it directly upside down and I love it.
hey so Emily Carroll is my absolute favorite horror artist and her stories are some of the greatest things i’ve ever had the ghastly pleasure to read. many of her comics are free online, such as the classic His Face All Red
She is great
Anya is live and ready to show you everything. Watch her strip, dance, and perform exclusive shows just for you. Interact in real-time and make your fantasies come true.
Free to watch • No registration required • HD streaming
How to learn Quantum Mechanics on your own How to learn Quantum Mechanics on your own This video gives you a some tips for learning quantum mechanics by yourself, for cheap, even if you don’t have a lot of math background.
Great document
New comic!!! Sorry it took me so long to make this one! XD
In the end, turns out it has 9 panels, not 10. But it’s still quite a lot… I’m hoping to be able to draw the next one more quickly!
Anyways… As someone whose native lnguage is Portuguese and who speaks English and understands a bit of Italian, this thing about the Peperone/Pepperoni has always been a mess for me! XD Enough for me to write a comic about it.
Remember that Giovanni is Italian in my headcanon. Born in Italy, I mean, not only a descendant. And yes, he does have Italian accent. :3
I was expecting a multiverse joke
Guzma fucking killed me
