#mdr1

Every time I see an "ISO stud" ad on fb or craigslist I am so tempted to respond as if I actually have an intact male, and require info on current health testing, pedigree, and with a comprehensive list of what their bitch has done. I know that my messages would most likely be ignored, because I highly doubt any of these dogs have done anything. However the funniest part about these ads is that they alway mention that their dog is already in heat! Like, dude, if you're the kind of person to just put out an ad for any old stud, you're probably not knowledgeable to know exactly how long she's been in heat, and in order for the timing to work, they'd probably have to find a stud that was available immediately if they were lucky enough to catch it quickly.

@lvtsoulstice                                                                                                        “This is a tangent, feel free to make a separate post in response to this but– MDR1 isn’t a problem in BCs? We’ve been doing pharmacology in vet tech classes and collies in general were mentioned for ivermectin sensitivities (more likely to cross the blood-brain barrier etc) due to the MDR1 gene, BCs were included. Border collies aren’t more likely to be sensitive to ivermectin?” From the research I have done with various friends, MDR1 is very rare in BCs. They are generally included solely because they are of the ‘collie’ type, and if I remember correctly, the only dogs that came up positive for it that was labeled ‘BC’ were dogs that were not proven BCs, ie, likely to be mixed. The theory (BC circle, at least) was that given the breed’s primary function as a sheep dog, whereas most other breeds exhibiting the MDR1 mutation were cattle dogs, basically became housepets, or were from other collie lines, was that natural selection took affect. Dogs with MDR1 ate ivermectin poop, or were treated with it, died. Farmers soft culled (or in some cases, hard culled) the parents and siblings out of worry, and thus, eliminated the gene early on. BC’s close cousin, the Old English Sheepdog, is also incredibly low - likely for this same reason. Collies, which were from the same landrace as those two (as well as the others), were quickly turned to more of a housepet/showy type dog, and thus, may not have had selection play its part. I don’t know collie history enough to verify this, I just know this is the rumor around the BC folks when this is brought up. You can see a bit on it on the BCboards linked below. “The Mutation of the ABCB1 gene associated with multidrug resistance 1 has been identified in the Border Collie. Though the exact frequency in the overall Border Collie population is unknown, in North America 1.3% out of 306 Border Collies were carriers and 0.3% were at-risk. In Europe, none of the 116 Border Collies tested in one study had inherited the mutation. Worldwide, the percentage of carriers ranges from 0% to 5% and the percentage of Border Collies at-risk for MDR1 ranges from 0% to 0.4%. “ - Pawprint Genetics. https://www.pawprintgenetics.com/products/tests/details/93/?breed=34 - 1%. http://vcpl.vetmed.wsu.edu/affected-breeds - Under 5% http://www.wisdompanel.com/mdr1_disease_screening/ - Under 5% http://www.bordercollie.org/boards/index.php?showtopic=4966 - No BC has been found with the MDR1 mutation of proven lineage. http://www.pnas.org/cgi/reprint/101/32/11725 - Actual report the above link refers to.