I am going to have a mental breakdown with this fertility stuff. The government and our healthcare system is fucking bullshit.

$14,000 for adoption and we could be waiting 1-10 years. $4,500 just to apply for the damn chance. And they also won’t let us apply until January cause they’re “full”.

Our family doctor today suggested with this next round to maybe look in to surrogacy. So that’s another $20,000 for an IVF cycle and then $60,000 for a surrogate (this one has a $8,500 application fee too).

I am never going to have a baby. This all seems so impossible and I am so upset. I am so tired. I don’t get why I am being punished like this. 

I am sad to say we have lost our first embaby. Despite being on progesterone, I started bleeding a week early. 

IVF is no a guarantee. It’s a sad, scary fact that you can spent thousands of dollars, pump yourself full of hormones, take medications by every way of administration possible and still end up with nothing. 

I knew to expect this. I knew the first transfer likely wouldn’t stick around. I knew that it really only is a 50/50 chance. 

But it still hurts. Another child of ours I am announcing to the world by way of loss. I feel like I am grieving not only this baby but all the others we have lost along the way. 

My mental health has been terrible the last few months. Accepting that our entire first cycle of IVF completely failed is a hard pill to swallow. I really thought the first cycle would be all that was needed (how silly of me). Doctors played it off like they weren’t even entirely sure I needed IVF and that this would be shoe-in for me. From a disappointing response to stims, a low amount of embryos and two failed transfers all I’ve gotten from my medical team is shock and apologies.

Infertility sucks. IVF sucks.

It is so incredibly heartbreaking and isolating. You are constantly trying to navigate in a world where others don’t understand you. You are constantly ridiculed and misunderstood for your loss and trauma. You become the elephant in the room that no one knows how to address. You are reprimanded by friends and family for not being able to be the same person you were before.

You fall behind everyone else and most leave you to be forgotten. People get tired of asking how you are. They get tired of feeling awkward around you. They get tired of putting in more effort. They get exhausted by your grief. Soon the phone stops ringing and the invites stop coming and you’re shut out.

The truth is this last year has been absolute torture for me. No one likes being the black sheep. I am already my own worst critic, to have others begin to criticize me just becomes too much.

I have no trust for my body. I have no LOVE for my body right now.

I have been a shell of a person and I can acknowledge it but there is no will left in me to change that right now. All the energy I have is being put towards moving forward, to surviving. We’ve been met with rejection every step of the way, but we won’t stop.

Repeated IVF Failures: Causes, Signs & Next Steps | Motherhood Fertility & IVF

Understanding Unexplained Infertility

Unexplained infertility occurs when a couple has been trying to conceive for a long period but routine fertility tests show normal results. These tests typically evaluate:

Ovulation and hormonal balance: Regular ovulation and balanced reproductive hormones ensure that a mature egg is released at the right time for fertilization.

Sperm quality and count: Healthy sperm with an adequate count, good motility, and proper structure increases the chances of successfully fertilizing the egg.

Uterine structure: A healthy and properly shaped uterus provides the ideal environment for embryo implantation and pregnancy development.

Fallopian tube openness: Open and functional fallopian tubes allow the sperm to reach the egg and enable the fertilized egg to travel safely to the uterus.

When all these parameters appear normal but pregnancy still does not occur, the condition is labeled unexplained infertility. However, in many cases the problem is not truly “unexplained.” Instead, the underlying issue may be hidden structural or microscopic abnormalities within the reproductive system. These subtle problems can interfere with fertilization, embryo implantation, or early pregnancy development, and they often require advanced surgical diagnosis and treatment.

Why IVF Sometimes Fails

IVF is designed to bypass many natural barriers to conception. However, IVF cannot always overcome structural or surgical problems in the reproductive organs. Some common hidden causes include:

Endometriosis affecting pelvic organs: A condition where tissue similar to the uterine lining grows outside the uterus, causing inflammation and affecting fertility.

Undetected uterine abnormalities: Structural issues inside the uterus that may not appear in routine scans but can interfere with implantation.

Blocked or damaged fallopian tubes: When the fallopian tubes are blocked or injured, sperm cannot reach the egg or the fertilized egg cannot reach the uterus.

Pelvic adhesions: Bands of scar tissue that cause pelvic organs to stick together, potentially disrupting normal reproductive function.

Scar tissue from previous infections or surgeries: Tissue damage caused by past infections or surgeries that can affect the reproductive organs and fertility.

Fibroids affecting embryo implantation: Non-cancerous growths in the uterus that may interfere with the embryo attaching properly to the uterine lining.

If these conditions are present, IVF success rates can decrease significantly. Without addressing the root cause, repeated IVF cycles may continue to fail. This is why a comprehensive surgical evaluation is sometimes necessary before continuing fertility treatments.

The Role of Advanced Reproductive Surgery

Advanced reproductive surgery allows doctors to directly visualize and treat hidden abnormalities that imaging tests may miss. Procedures such as laparoscopy and hysteroscopy help fertility specialists examine the uterus, fallopian tubes, ovaries, and surrounding pelvic structures in detail.

These minimally invasive procedures can help:

Remove endometriosis lesions: Surgical removal of endometriosis tissue to reduce inflammation and improve reproductive organ function.

Correct uterine abnormalities: Surgical correction of structural issues in the uterus to support healthy embryo implantation.

Remove fibroids or polyps: Eliminate non-cancerous growths from the uterus that may interfere with fertility or pregnancy.

Treat pelvic adhesions: Releasing scar tissue that causes pelvic organs to stick together, restoring normal reproductive anatomy.

Restore fallopian tube function: Repairing or clearing blocked fallopian tubes to allow the egg and sperm to meet naturally.

Improve the uterine environment for implantation: Create a healthier uterine lining that increases the chances of successful embryo attachment and pregnancy.

When performed by an experienced fertility surgeon, these procedures can significantly improve the chances of natural conception or increase the success rates of IVF.

Dr. Dhaval Baxi’s MCh Surgical Expertise

Dr. Dhaval Baxi is known for his advanced surgical expertise in the field of reproductive medicine. With specialized MCh-level training in minimally invasive gynecological surgery, he focuses on identifying and treating complex infertility conditions that often remain undiagnosed. His surgical precision allows him to perform delicate fertility-preserving procedures while maintaining the integrity of reproductive organs.

Some of the advanced procedures performed include:

Laparoscopic Surgery for Infertility

Laparoscopy is a minimally invasive surgical technique that allows the doctor to examine the pelvic organs using a tiny camera inserted through a small incision.

This procedure helps diagnose and treat:

Endometriosis: A condition where tissue similar to the uterine lining grows outside the uterus, causing inflammation and potentially affecting fertility.

Pelvic adhesions: Bands of scar tissue that cause pelvic organs to stick together, which can disrupt normal reproductive function.

Ovarian cysts: Fluid-filled sacs that develop on the ovaries and may sometimes interfere with ovulation or fertility.

Tubal blockages: Blocked fallopian tubes that prevent the sperm from reaching the egg or stop the fertilized egg from reaching the uterus.

Hysteroscopic Surgery

Hysteroscopy allows the doctor to examine the inside of the uterus using a thin telescope inserted through the cervix. This procedure helps detect abnormalities inside the uterine cavity that may interfere with implantation.

Conditions treated through hysteroscopy include:

Uterine polyps: Small growths in the inner lining of the uterus that can interfere with embryo implantation.

Submucosal fibroids: Fibroids that grow inside the uterine cavity and may affect fertility or cause implantation problems.

Uterine septum: A congenital condition where a thin wall divides the uterus, which can increase the risk of infertility or miscarriage.

Scar tissue (Asherman’s syndrome): Scar tissue inside the uterus that can disrupt the uterine lining and affect embryo implantation.

Treatment for Endometriosis-Related Infertility

Endometriosis is one of the most common yet underdiagnosed causes of infertility. It occurs when tissue similar to the uterine lining grows outside the uterus, causing inflammation, pain, and fertility problems. Through advanced laparoscopic surgery, Dr. Dhaval Baxi carefully removes endometriosis lesions while preserving ovarian function. This improves fertility outcomes and can significantly increase the chances of pregnancy.

Personalized Treatment Approach

Every infertility case is unique. Instead of applying a one-size-fits-all solution, Dr. Dhaval Baxi focuses on a personalized diagnostic and treatment approach.

This includes:

Detailed fertility evaluation: A comprehensive assessment of both partners to identify possible factors affecting fertility.

Advanced imaging and testing: Specialized diagnostic tests used to detect hidden reproductive issues that routine tests may miss.

Surgical correction of underlying problems: Minimally invasive procedures performed to treat structural abnormalities affecting fertility.

Optimized fertility treatments after surgery: Personalized fertility treatments planned after surgical correction to improve the chances of successful pregnancy.

When Should Couples Consider Surgical Evaluation?

Couples may benefit from advanced fertility surgery if they experience:

Repeated IVF failure: When multiple IVF cycles do not result in pregnancy despite good embryos and proper treatment.

Unexplained infertility: A condition where couples cannot conceive even though standard fertility tests show normal results.

Chronic pelvic pain: Persistent pain in the pelvic region that may indicate underlying reproductive conditions affecting fertility.

Endometriosis symptoms: Symptoms such as severe menstrual pain, pelvic discomfort, or pain during intercourse that may suggest endometriosis.

Abnormal uterine findings on ultrasound: Unusual structures or growths in the uterus detected during ultrasound that may affect implantation.

Previous pelvic infections or surgeries: Past infections or surgical procedures in the pelvic area that may have caused scarring or damage to reproductive organs.

Restoring Hope in Difficult Fertility Cases

For many couples struggling with infertility, repeated treatment failures can feel discouraging. However, advanced surgical techniques have opened new possibilities for diagnosing and treating complex fertility problems. With precise surgical expertise and a comprehensive fertility approach, specialists like Dr. Dhaval Baxi help uncover hidden causes of male  infertility and provide effective treatment solutions. By combining advanced reproductive surgery with modern fertility treatments, couples who once believed pregnancy was impossible can often achieve their dream of parenthood.

Conclusion

While IVF is a powerful fertility treatment, it is not always the complete solution for every infertility case. Hidden conditions such as endometriosis, uterine abnormalities, and pelvic adhesions can prevent successful pregnancy even with IVF. Through advanced minimally invasive surgical techniques, specialists like Dr. Dhaval Baxi are able to diagnose and correct these underlying problems. This approach not only improves IVF success rates but can also restore the possibility of natural conception for many couples.For couples facing unexplained infertility or repeated IVF failures, a surgical fertility evaluation may be the key step toward finally achieving a successful pregnancy.

FAQs

What is unexplained infertility?

Unexplained infertility is diagnosed when standard fertility tests show normal results, but a couple is still unable to conceive after trying for a significant period.

Can surgery improve IVF success rates?

Yes. Correcting conditions such as fibroids, endometriosis, or uterine abnormalities through surgery can significantly improve IVF outcomes.

Is fertility surgery safe?

Most fertility surgeries today are minimally invasive procedures such as laparoscopy and hysteroscopy. These procedures involve small incisions, faster recovery, and minimal complications when performed by experienced specialists.

When should I see a fertility surgeon?

Experiencing repeated IVF failure during attempts at conception can be emotionally and physically draining for couples. After investing their hopes and resources in IVF, multiple failures can become overwhelming for them. However, it is imperative for couples to note that failed IVF cycles what next is a question that has multiple answers. With advancements in IVF and infertility treatment, multiple IVF failure is not an end for couples, and they are able to conceive successfully.

What is Repeated IVF Failure?

Repeated IVF failure is defined as the inability of a couple to achieve pregnancy after multiple IVF attempts, mostly after achieving good-quality embryos. This brings forth the concern of underlying causes of IVF failure, which might not have been diagnosed earlier. IVF failure what next is a question on every couple’s mind.

Common Causes: IVF Failure Reasons

The first step towards increasing the success rates of IVF treatment is to understand the reasons for the failure of IVF treatment. There are a number of medical and lifestyle reasons that can lead to unsuccessful IVF treatment cycles. These include:

Why IVF Fails: Common Reasons and How to Improve Success

In vitro fertilization (IVF) remains one of the most effective assisted reproductive technologies available, helping millions achieve parenthood. However, it's not always successful on the first try—or even the second. Understanding why IVF fails is crucial for couples navigating this emotional and financial journey. In 2025, global IVF success rates average around 25-30% per cycle, though they vary significantly by age, clinic, and individual factors. Live birth rates per cycle can reach 40-55% for women under 35 in top clinics, but drop sharply with advancing age.

This comprehensive guide explores the most common reasons IVF fails, backed by recent insights, and provides practical, evidence-based strategies to boost your chances in future cycles. Whether you're preparing for your first IVF or analyzing a previous failure, knowledge empowers better decisions. Choosing a leading IVF hospital in Uttar Pradesh with experienced fertility specialists and advanced laboratory support can significantly improve treatment outcomes.

Understanding IVF Success Rates in 2025

Before diving into failures, let's set realistic expectations. According to recent data:

Women under 35: Live birth rates often 40-55% per cycle or transfer.

Ages 35-37: Around 30-40%.

Ages 38-40: 20-26%.

Over 40: Often 5-15% with own eggs, but 50%+ with donor eggs.

These figures come from sources like CDC reports and clinic aggregates, where cumulative success after multiple cycles can exceed 50-70% for many patients. Factors like embryo quality, uterine health, and lifestyle play huge roles.

Common Reasons Why IVF Fails

IVF involves multiple steps—ovarian stimulation, egg retrieval, fertilization, embryo culture, and transfer—any of which can contribute to failure. Here are the top reasons, drawn from fertility experts and recent studies.

Poor Embryo Quality and Chromosomal Abnormalities This is often cited as the #1 reason for IVF failure. Even with good-looking embryos, many have chromosomal issues (aneuploidy) that prevent implantation or cause early miscarriage. Chromosomal abnormalities rise dramatically with maternal age: By the mid-40s, over 75% of embryos may be abnormal. On average, only about 25% of transferred embryos result in live birth. Preimplantation genetic testing (PGT-A) can help identify euploid embryos, but not all clinics use it routinely.

Advanced Maternal Age Age is the single biggest predictor. Egg quantity and quality decline after 35, accelerating after 37-40. Older eggs lead to poorer fertilization, embryo development, and higher aneuploidy rates. While sperm quality also matters, female age dominates statistics.

Poor Egg or Ovarian Response Some women produce few eggs during stimulation due to low ovarian reserve (measured by AMH or antral follicle count). Poor responders may get fewer embryos, reducing odds. This ties closely to age but can occur earlier due to conditions like diminished ovarian reserve or endometriosis.

Sperm Quality Issues (Male Factor) Even with ICSI (intracytoplasmic sperm injection), high DNA fragmentation, low motility, or abnormal morphology can impair fertilization or embryo viability. Sperm problems contribute to failed fertilization or early arrest in some cycles.

Implantation Failure and Uterine Factors Even chromosomally normal embryos may not implant. Causes include thin endometrial lining (<7-8mm), poor receptivity (out-of-sync "window of implantation"), uterine abnormalities (fibroids, polyps, adenomyosis), or inflammation. The "receptivity array" tests (like ERA) help identify timing issues in some cases.

Hormonal Imbalances Inadequate progesterone support post-transfer, estrogen-progesterone mismatch, or thyroid issues can hinder implantation. Luteal phase support is standard, but individual variations occur.

Lifestyle and Environmental Factors Smoking, excessive alcohol, obesity (BMI >30), poor diet, high stress, and exposure to toxins reduce success. These affect egg/sperm quality and overall response.

Other Factors

Lab conditions and embryo culture techniques.

Immune responses (though controversial).

Undiagnosed conditions like insulin resistance or clotting disorders.

Multiple failed transfers sometimes point to subtle issues like endometriosis or hydrosalpinx.

Many failures are multifactorial—rarely one single cause.

This illustrative chart shows typical IVF success rate decline by female age, highlighting why age is a key factor in cycle outcomes.

How to Improve IVF Success Rates: Evidence-Based Strategies

The good news? Many factors are modifiable. Clinics and patients now use advanced tools and lifestyle optimizations to boost odds.

Choose a High-Success Clinic Select one with strong lab standards, experienced embryologists, and transparent success rates (check CDC or HFEA data). Clinics using time-lapse imaging and AI for embryo selection often report higher outcomes.

Optimize Pre-IVF Health

Maintain healthy BMI (18.5-24.9).

Follow a Mediterranean-style diet rich in antioxidants (fruits, veggies, nuts, fish).

Exercise moderately; avoid extremes.

Quit smoking/alcohol; limit caffeine.

Take evidence-based supplements (e.g., CoQ10 for egg quality, prenatals with folic acid, omega-3s). Start 3+ months before stimulation.

Consider Advanced Testing and Techniques

PGT-A for chromosomal screening (especially over 35).

ERA (Endometrial Receptivity Analysis) for transfer timing.

Non-invasive embryo assessment or time-lapse monitoring.

Frozen embryo transfer (FET) often outperforms fresh in many cases, allowing better endometrial prep.

Address Male Factors Improve sperm with antioxidants, lifestyle changes, or DNA fragmentation testing if needed.

Manage Stress and Support Emotional Health Chronic stress affects hormones. Yoga, acupuncture (some evidence for improved implantation), counseling, or support groups help.

Tailor Protocols Work with your specialist for personalized stimulation (mild vs. aggressive), trigger shots, or adjuncts like growth hormone in poor responders.

Plan for Multiple Cycles Cumulative success rises significantly after 2-3 attempts. Banking embryos or using donor options (eggs/sperm) dramatically boosts rates for challenging cases.

In 2025, innovations like AI embryo selection, non-invasive genetic testing, and refined protocols are pushing success higher than ever.

This infographic outlines key lifestyle and medical steps to enhance IVF outcomes, from diet to advanced testing.

Final Thoughts

IVF failure is heartbreaking but common—even in the best scenarios. Most failures stem from biological factors like embryo quality or age, not something you "did wrong." The path forward involves thorough evaluation after a failed cycle, addressing modifiable risks, and leveraging modern advancements.