#fgf21

A pioneering research study published today in Cell Metabolism details how the hormone FGF21 (fibroblast growth factor 21) can reverse the effects of fatty liver disease in mice. The hormone works primarily by signaling the brain to improve liver function. University of Oklahoma researcher Matthew Potthoff, Ph.D., is the lead author of the study, which provides valuable insight about the…

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In mice and humans, the key to unlocking this natural process was found to be a gut microbe and its metabolites – the compounds it produces during digestion.

By increasing the abundance of this one gut microbe in diabetic mice, researchers led by a team at Jiangnan University in China have shown they can "orchestrate the secretion of glucagon-like peptide-1".

Glucagon-like peptide-1 (GLP-1) is a hormone that is naturally produced by the body and which helps regulate blood sugar levels and feelings of fullness. GLP-1's release is stimulated by certain foods and gut microbes, and its mechanism of action is mimicked by drugs like semaglutide (the ingredient behind Ozempic).

People with type 2 diabetes typically have impaired GLP-1 function, leading to issues with blood sugar control, which is why Ozempic and other GLP-1 agonists work as treatments.

These drugs mimic natural processes in the body, and while they have proved very effective, some researchers want to figure out how to get the body to produce more GLP-1 on its own.

"A growing body of research has revealed that our cravings for dietary components originate from signals sent from the gut, a key organ in transmitting dietary preferences," explain the authors.

"However, which genes, gut flora, and metabolites in the gut microenvironment are involved in the regulation of sugar preference is currently unclear."

The new research suggests gut microbes like Bacteroides vulgatus and their metabolites may help shape a person's sweet tooth.

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Sure enough, the research team found that when mice were treated with a metabolite of B. vulgatus, it boosted GLP-1 secretion, which then also triggered the secretion of FGF21.

Together, this meant more blood sugar control and fewer sugar cravings in mice.

Whether the same will extend to humans remains to be seen, but the authors claim their study "provides a strategy for diabetes prevention."

…”two novel loci; a common variant in RARB locus for carbohydrate intake and a rare variant in DRAM1 locus for protein intake, and corroborating earlier FGF21 and FTO findings.” Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Jordi Merino, Hassan S. Dashti, […]Toshiko…

Keşfedilen yeni gen vücuttaki yağ oranını azaltıyor

Yediklerimizin oranı her zaman bilinçli seçimlere bağlı olarak kendini göstermez. Bu bazen genetik faktörlere bağlı olarak değişiklik gösterir.

FG21 GENİ KARBONHİDRAT VE LİPİT ALIMINI ETKİLİYOR

Özellikle de FG21 olarak adlandırılan bir genin karbonhidrat ve lipit (yağ) alımını da etkilediği tespit edildi.

YAĞ ORANINDA AZALMA MEYDANA GELİYOR

Exeter…

Za słabość do słodyczy odpowiada wątroba

Osoby posiadające określony wariant genu sterującego wydzielaniem hormonu FGF21 w wątrobie mają większą skłonność do sięgania po słodkie przekąski – czytamy na łamach “Cell Metabolism”.

First liver-generated hormone to work with brain to control sugar-intake identified. Thoughts health innovators?

The recent surge in obesity prevalence has been greatly influenced by food intake and diet composition. Energy from food comes in three macronutrient forms- fat, protein, and carbohydrate.  Over the past 50 years, excessive consumption of carbohydrate in the U.S. has been linked with metabolic disease. However, although there is abundant physiological evidence for independent appetites for fats,…