#dutasteride

I decided to try going off dutasteride for a while to see if the other medication/dietary changes were enough to hold off the hidradenitis suppurativa... 24 days in, the lesions are back.

Dutasteride has a very long elimination half-life: more than a month, in comparison to less than a day for finasteride and spiro. 3-8 weeks is about when I expected problems to start, if they were going to. So, experiment cancelled: I do still need a T blocker. Re-started it today.

Yup! I'll write out what I've read up on for my own purposes. Standard disclaimer: I don't know what I don't know, speak to an endocrinologist if possible, get regular blood tests if you can.

The main two DHT blockers (that preventing testosterone being metabolised into DHT) are finasteride and dutasteride, with dutasteride having a stronger effect.

I used to take 1mg/day finasteride, the recommended medication and dose for hair loss prevention. However it has a short (6 hour) half-life in the body and I often forget to take it, so I switched to 1mg/3days dutasteride which remains in the body for a much longer time (several weeks half-life). This is not a recommended dosage or regimen - normal dosage is 0.5mg/day for hair loss - but is likely safe since it can be prescribed up to 5mg/day.

Potentially desirable effects of DHT blockers (compared to testosterone without DHT blockers)

Prevents head hair loss on DHT-sensitive hair follicles. For some people it can also reverse existing hair loss, though I wouldn't completely count on that.

Somewhat prevents body and facial hair from increasing. I haven't seen any evidence for reversal though.

It suppresses bottom growth.

Reduces skin oil production and thus may reduce acne.

DHT blockers likely don't affect: muscle growth, voice deepening, fat redistribution, height increase (if your bones are not fully ossified).

Side effects

DHT blockers affect fetal development, so all precautions should be taken to prevent anyone who is pregnant / trying to get pregnant from accidentally ingesting it. This means pill cutters shouldn't be shared for different medications, and you can't donate blood for as long as the DHT blocker is in your body (1 week for finasteride, 6-12 months for dutasteride).

Studies done on cis men taking DHT blockers show a potential increase in depression and lowered libido. However I don't have any information on whether the same effect applies to somebody with starting at a baseline of low testosterone and low DHT, then taking testosterone with a DHT blocker.

This systematic review is quite helpful and uses fairly understandable language.

Things I know that I don't know

The metabolism of testosterone doesn't end at DHT - DHT is then metabolised into other products, and so on. I have not looked into the downstream effects of blocking production of DHT yet, which may be significant if you are taking a near-total DHT blocker like dutasteride long-term.

I have seen many posts on bodybuilding forums (most reliable source of information /s) saying that DHT blocks the effects of estrogens by competing for estrogen receptors. As far as I can tell, DHT does not seem to bind effectively to estrogen receptors, so I somewhat doubt this claim. There is convincing evidence that DHT blockers increase the risk of gynecomastia in cis men, but I haven't yet been able to find out what the mechanism is.

Key Benefits

· Most comfortable Injectable Dutasteride DUTASTERIDE 0.01% IN LIPOSOMES

· Effectively reduces scalp DHT levels

· Slows progression of follicular miniaturization

· Promotes thicker, stronger hair regrowth

· Demonstrates superior efficacy compared to finasteride

· Long half-life ensures sustained therapeutic effect

· Well tolerated in mesotherapy with reduced systemic side effects

 Key Mechanism & Role

· Dutasteride

· Dual inhibition of Type I & II 5-alpha reductase

· Prevents conversion of testosterone to DHT

· Prolongs the anagen (growth) phase of the hair cycle

· Improves hair density and follicle longevity in AGA

· Recommended Usage Guidelines

Dual 5-Alpha Reductase Inhibitor for Androgenetic Alopecia (AGA)

Androgenetic alopecia is primarily driven by dihydrotestosterone (DHT), which shortens the anagen phase and leads to progressive follicular miniaturization. Dutasteride inhibits both Type I and Type II 5-alpha reductase enzymes, resulting in a significant reduction in scalp DHT levels and improved follicular preservation. Liposomal delivery enhances follicular targeting while minimizing systemic exposure.

Key Benefits

· Most comfortable Injectable Dutasteride DUTASTERIDE 0.01% IN LIPOSOMES

· Effectively reduces scalp DHT levels

· Slows progression of follicular miniaturization

· Promotes thicker, stronger hair regrowth

· Demonstrates superior efficacy compared to finasteride

· Long half-life ensures sustained therapeutic effect

Tamsulosin and Dutasteride Tablets: Dual-action therapy for enlarged prostate

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Background Gli androgeni hanno una vasta gamma di effetti sia negli uomini che nelle donne e la loro disregolazione può dare origine a una varietà di disturbi clinici, tra cui la sindrome dell’ovaio policistico, il disturbo endocrino più comune nelle donne, che colpisce fino al 7% della popolazione; irsutismo; acne vulgaris; iperplasia prostatica; e calvizie maschile. Esistono già diversi…