#connectomics

Into the Dense

This study describes a new approach for homing in on details of the brain's densely packed neurons and their connections. Light-microscopy-based connectomics (LICONN) combined with tissue expansion and segmentation enables 3D reconstruction of networks at high-resolution

Read the published research article here

Image from work by Mojtaba R. Tavakoli and colleagues

Institute of Science and Technology Austria, Klosterneuburg, Austria

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature, May 2025

Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction. Adams, W., Graham, J. N., Han, X., & Riecke, H. (2019). PLOS Computational Biology, 15(1), e1006611.

A Gestalt inference model for auditory scene segregation. Chakrabarty, D., & Elhilali, M. (2019). PLOS Computational Biology, 15(1), e1006711.

Inhibitory effect of ultrasonic stimulation on the voltage-dependent potassium currents in rat hippocampal CA1 neurons. Cui, K., Zhang, S., Sun, J., Zhang, X., Ding, C., & Xu, G. (2019). BMC Neuroscience, 20(1), 3.

Dopamine type 1- and 2-like signaling in the modulation of spatial reference learning and memory. Daba Feyissa, D., Sialana, F. J., Keimpema, E., Kalaba, P., Paunkov, A., Engidawork, E., … Korz, V. (2019). Behavioural Brain Research, 362, 173–180.

Binocular Modulation of Monocular V1 Neurons. Dougherty, K., Cox, M. A., Westerberg, J. A., & Maier, A. (2019). Current Biology, 29(3), 381–391.e4.

Attention reorganizes as structure is detected in dynamic action. Hard, B. M., Meyer, M., & Baldwin, D. (2019). Memory & Cognition, 47(1), 17–32.

Interneuronal gap junctions increase synchrony and robustness of hippocampal ripple oscillations. Holzbecher, A., & Kempter, R. (2018). European Journal of Neuroscience, 48(12), 3446–3465.

Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour. Jennings, J. H., Kim, C. K., Marshel, J. H., Raffiee, M., Ye, L., Quirin, S., … Deisseroth, K. (2019). Nature, 565(7741), 645–649.

Astrocyte-induced positive integrated information in neuron-astrocyte ensembles. Kanakov, O., Gordleeva, S., Ermolaeva, A., Jalan, S., & Zaikin, A. (2019). Physical Review E, 99(1), 012418.

Predicting change: Approximate inference under explicit representation of temporal structure in changing environments. Marković, D., Reiter, A. M. F., & Kiebel, S. J. (2019). PLOS Computational Biology, 15(1), e1006707.

Spatial synchronization codes from coupled rate-phase neurons. Monaco, J. D., De Guzman, R. M., Blair, H. T., & Zhang, K. (2019). PLOS Computational Biology, 15(1), e1006741.

Hippocampal place cell encoding of sloping terrain. Porter, B. S., Schmidt, R., & Bilkey, D. K. (2018). Hippocampus, 28(11), 767–782.

Physical brain connectomics. Robinson, P. A. (2019). Physical Review E, 99(1), 012421.

Locus Coeruleus tracking of prediction errors optimises cognitive flexibility: An Active Inference model. Sales, A. C., Friston, K. J., Jones, M. W., Pickering, A. E., & Moran, R. J. (2019). PLOS Computational Biology, 15(1), e1006267.

Short-term synaptic depression can increase the rate of information transfer at a release site. Salmasi, M., Loebel, A., Glasauer, S., & Stemmler, M. (2019). PLOS Computational Biology, 15(1), e1006666.

Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode. Seo, C., Guru, A., Jin, M., Ito, B., Sleezer, B. J., Ho, Y.-Y., … Warden, M. R. (2019). Science, 363(6426), 538–542.

STRFs in primary auditory cortex emerge from masking-based statistics of natural sounds. Sheikh, A.-S., Harper, N. S., Drefs, J., Singer, Y., Dai, Z., Turner, R. E., & Lücke, J. (2019). PLOS Computational Biology, 15(1), e1006595.

Sensory coding is impaired in rat absence epilepsy. Studer, F., Laghouati, E., Jarre, G., David, O., Pouyatos, B., & Depaulis, A. (2018). Journal of Physiology, 597(3), JP277297.

Sour grapes and sweet victories: How actions shape preferences. Vinckier, F., Rigoux, L., Kurniawan, I. T., Hu, C., Bourgeois-Gironde, S., Daunizeau, J., & Pessiglione, M. (2019). PLOS Computational Biology, 15(1), e1006499.

Meta-Research Bonus Paper:

Science, Volume 389, Issue 6759, July 2025. Summary Without access to the actual content of Science, Volume 389, Issue 6759, July 2025, I can only provide a general summary. This issue likely contains a collection of peer-reviewed scientific research articles, perspectives, and reviews covering a range of scientific disciplines. Expect breakthroughs, in-depth analyses, and the latest advancements…

A part of it is definitely context however, and neural maturation in a state that is non-neurotypical may lead to structural differences in certain brain regions, which may make it easier to separately consolidate memory and use separate context for reaction and interaction within certain areas like the PTO junction

Highly precise wiring in the cerebral cortex | Max Planck Society

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz…