Dr Abdullah Farhan

New York University (New York, NY) Read more about his post… Credits: Source Disclaimer

Background: Neuroendocrine prostate cancer (NEPC) is an aggressive, treatment-refractory state that often emerges under androgen-receptor pathway inhibition. We hypothesized that dysregulated ubiquitination underpins NEPC lineage plasticity and that integrating bulk and single-cell transcriptomes would define a ubiquitination-centered signature and tumor microenvironment (TME) circuits of…

Background: Neuroendocrine prostate cancer (NEPC) is an aggressive, treatment-refractory state that often emerges under androgen-receptor pathway inhibition. We hypothesized that dysregulated ubiquitination underpins NEPC lineage plasticity and that integrating bulk and single-cell transcriptomes would define a ubiquitination-centered signature and tumor microenvironment (TME) circuits of…

Background: [¹⁸F]FDG PET/CT can be used to diagnose suspected new-onset giant cell arteritis (GCA), but it is unclear, whether visual or semiquantitative evaluation yields the highest accuracy. We therefore aimed to compare both methods with regard to diagnostic accuracy within the same patient. Methods: This single centre study included all ≥ 50 year-old patients undergoing [¹⁸F]FDG PET/CT…

Type: Full-Time Posted: 1 day ago Application Due: Open Until Filled Category: Faculty Affairs The Director of Faculty Development and Calibration provides leadership in planning, implementing, and evaluating faculty development initiatives and faculty calibration processes within the predoctoral dental program. This position promotes excellence in teaching, consistency in clinical…

Larkin University -School of Dental Medicine (Winter Garden, FL) Read more about his post… Credits: Source Disclaimer

Gut dysbiosis-driven macrophage polarization plays a critical role in the pathogenesis of ulcerative colitis (UC). Dipsacoside B (DB), a natural saponin, possesses potential anti-inflammatory properties; however, its influence on mucosal immunity and the gut microbiota remains to be elucidated. To evaluate the therapeutic effects of DB, this study employed a DSS-induced colitis model in C57BL/6…

When bird flu jumped to cows, just 10 viral particles were enough to cause infection Read more about this post… Credits: Source Disclaimer

By acquiring an energy metabolism-related gene via ancient horizontal transfer from a bacterial symbiont, the deep-sea supergiant isopod gains the ability to reprogram its energy allocation, enabling survival under prolonged starvation. Read more about this post… Credits: Source Disclaimer

Location: NashuaJob Type: Full-Time Job Number: 202500218 Division: Div of Nursing & Health Professions DepartmentNursing and Health Professions Description The RN Coordinator of Clinical Faculty and Placements is responsible for securing clinical placements and maintaining adequate clinical and simulation instructional capacity to support projected nursing program enrollment. This position…

Cornell University (Ithaca, NY) Read more about his post… Credits: Source Disclaimer

Ticks are important vectors of pathogens affecting human and animal health, making the identification of tick-borne agents essential. This study focused on the understudied winter tick, Alloceraea inermis (syn. Haemaphysalis inermis), which is widely distributed across Eurasia and, in some regions, appears to be increasing in occurrence. This species may play an important role in maintaining and…

Burnet, F. M. A modification of Jerne’s theory of antibody production using the concept of clonal selection. Aust. J. Sci. 20, 67–69 (1957). Google Scholar  Ozcan, A., Vicanolo, T., Angeli, V., Rinkevich, Y. & Hidalgo, A. Structural immunity: immune cells as architects of tissue barriers. Nat. Rev. Immunol. 26, 314–325 (2025). Article  PubMed  Google Scholar  Netea, M. G. et al. Defining…

Background: Colorectal cancer (CRC) is highly heterogeneous, which limits the consistency of benefit from immune checkpoint blockade. SPTBN2 has recently been implicated as a candidate biomarker in CRC, but its cross-omics features and potential links to the tumor immune microenvironment remain insufficiently characterized. Methods: We integrated multi-omics profiles from TCGA and GEO,…

A 14-protein plasma signature identifies individuals benefiting from anti-IL-1β-based lung cancer risk reduction and demonstrates how diverse tumor-promoting factors converge on the induction of an alveolar transitional state that underlies lung tumorigenesis. Read more about this post… Credits: Source Disclaimer

Tarrant County College District (District, TX) Read more about his post… Credits: Source Disclaimer

Background: Therapeutic decisions in clinical oncology are commonly established through interdisciplinary consensus in multidisciplinary cancer conferences (MCC). Artificial intelligence (AI) may support these processes by generating data-driven treatment recommendations (TR). We developed and evaluated an explainable AI system designed to reproduce MCC-based treatment decisions for metastatic…