Dr Abdullah Farhan

One in every 3 faculty posts vacant in top technical institutes | RTI data  The Hindu Read more about his post… Credits: Source Disclaimer

Nuclear and cytoplasmic proteomics uncover a nuclear pool of cytoskeletal proteins, including MAP1B, whose shuttling to the nucleus increases BRG1/BAF chromatin association and regulates brain development. Read more about this post… Credits: Source Disclaimer

Scientists have uncovered a gigantic hidden structure beneath East Antarctica, linking several enormous basins buried under miles of ice into a single fan-shaped formation stretching across the continent. Credit: Shutterstock Scientists have discovered a colossal hidden structure beneath Antarctica that could reshape our understanding of the continent’s past and present. Scientists have…

Background: Donor-derived cell-free DNA (dd-cfDNA) enables early detection and monitoring of graft injury after transplantation. However, clinical adoption has been slowed by pricing and limited reimbursement. Commercially available assays based on different methodologies are used in practice, but their comparability remains uncertain. Demonstrating interchangeability may support more…

Background: The aggressive and diverse subtype of breast cancer known as triple-negative breast cancer (TNBC) has poor clinical outcomes and few specific therapeutic choices. Tumor-infiltrating lymphocytes (TILs), T-cell receptor-engineered T cells, and chimeric antigen receptor T (CAR-T) cells are examples of adoptive cell therapy (ACT), which has become a promising immunotherapeutic approach.…

Nanomedicine has revolutionized oncology through targeted drug delivery and theranostic applications. However, its clinical translation remains a formidable challenge, primarily due to the translational gap created by conventional preclinical models. These models often fail to recapitulate patient-specific tumor heterogeneity and the complex dynamics of the tumor microenvironment. This review…

Nanomedicine has revolutionized oncology through targeted drug delivery and theranostic applications. However, its clinical translation remains a formidable challenge, primarily due to the translational gap created by conventional preclinical models. These models often fail to recapitulate patient-specific tumor heterogeneity and the complex dynamics of the tumor microenvironment. This review…

Nanomedicine has revolutionized oncology through targeted drug delivery and theranostic applications. However, its clinical translation remains a formidable challenge, primarily due to the translational gap created by conventional preclinical models. These models often fail to recapitulate patient-specific tumor heterogeneity and the complex dynamics of the tumor microenvironment. This review…

Tumor cells rely heavily on vascular nutrient supply and glucose metabolism to sustain proliferation, while maintaining redox homeostasis through reprogrammed antioxidant systems, making it difficult for single starvation therapy or chemodynamic therapy (CDT) alone to achieve durable and effective antitumor efficacy. To address these limitations, we developed a cancer cell membrane (CMC)-coated…

LEAPER 3.0, a structurally optimized dual-bulge ADAR-recruiting RNA design platform, achieves precise and efficient endogenous A-to-I RNA editing across diverse ADAR contexts. Read more about this post… Credits: Source Disclaimer

The Leibniz-Institut für Analytische Wissenschaften – ISAS – e. V. develops efficient analytical methods for health research. Thus, it contributes to the improvement of the prevention, early diagnosis, and therapy of diseases like cardiovascular diseases or cancer. Overall, the institute strives to advance precision medicine by combining knowledge from different fields such as biology, chemistry,…

The Leibniz-Institut für Analytische Wissenschaften – ISAS – e. V. develops efficient analytical methods for health research. Thus, it contributes to the improvement of the prevention, early diagnosis, and therapy of diseases like cardiovascular diseases or cancer. Overall, the institute strives to advance precision medicine by combining knowledge from different fields such as biology, chemistry,…

University of San Diego (San Diego, CA) Read more about his post… Credits: Source Disclaimer

The Leibniz-Institut für Analytische Wissenschaften – ISAS – e. V. develops efficient analytical methods for health research. Thus, it contributes to the improvement of the prevention, early diagnosis, and therapy of diseases like cardiovascular diseases or cancer. Overall, the institute strives to advance precision medicine by combining knowledge from different fields such as biology, chemistry,…

Chew, N. W. S. et al. The global burden of metabolic disease: data from 2000 to 2019. Cell Metab. 35, 414–428.e3 (2023). Article  CAS  PubMed  Google Scholar  Liu, T.-C. et al. Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host Microbe 29, 988–1001.e6 (2021). Article  CAS  PubMed  PubMed Central  Google…

Prion-based protein self-assembly enables reversible switching of genome-maintenance pathways during rapid adaptation and the emergence of drug resistance. Read more about this post… Credits: Source Disclaimer

Polyethylene glycol (PEG) has been extensively utilized in food, cosmetics, and pharmaceutical fields, especially in the realm of nanomedicines, where it serves as a pivotal excipient to prolong the nanoparticles’ circulation half-life. Contrary to its historical perception as being nonimmunogenic, pre-existing anti-PEG antibodies have been widely detected in human even in individuals without…