Dr Abdullah Farhan

One in every 3 faculty posts vacant in top technical institutes | RTI data  The Hindu Read more about his post… Credits: Source Disclaimer

Neurological symptoms are among the most debilitating features of long COVID, but their underlying mechanisms remain poorly understood. Santos Guedes de Sá et al. provide evidence that diverse autoantibodies raised during acute SARS-CoV-2 infection persist in individuals with long COVID and contribute directly to these manifestations. To understand the antigenic specificity of these antibodies…

Borin, J. M. et al. Rapid bacteria–phage coevolution drives the emergence of multiscale networks. Science 382, 674–678 (2023). Article  CAS  PubMed  Google Scholar  Kauffman, K. M. et al. Resolving the structure of phage–bacteria interactions in the context of natural diversity. Nat. Commun. 13, 372 (2022). Article  CAS  PubMed  PubMed Central  Google Scholar  Vos, M., Birkett, P. J., Birch,…

Live imaging covering the entire human pre-implantation development reveals that the second mitotic division is the most error-prone, where stochastic centriole overduplication predisposes 2-cell embryos to missegregating chromosomes and arresting before the 8-cell stage. By contrast, later embryonic arrest involves endoplasmic reticulum stress. Read more about this post… Credits:…

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease caused by the selective loss of upper and lower motor neurons. There is a considerable variability in the disease progression of sporadic ALS, but the molecular basis for phenotypic heterogeneity remains largely unknown. ALS patients often manifest systemic metabolic abnormalities such as glucose intolerance and…

Metal-coordinated hydrogels offer a strategy to integrate local drug retention, responsive release, and multimodal therapy, but assigning structural and therapeutic roles to a single metal complex remains challenging. Here, we report an injectable polypyridyl Ru(II)-scaffolded hydrogel, Ru(fmb)3HADH-PDA@IR780, formed by dynamic Schiff-base crosslinking and loaded with polydopamine nanoparticles…

Transposable elements, far from being genomic clutter, have emerged as dynamic genomic regulators that shape when, where, and how genes are turned on across development and disease. Read more about this post… Credits: Source Disclaimer

One in every 3 faculty posts vacant in top technical institutes | RTI data  The Hindu Read more about his post… Credits: Source Disclaimer

Nuclear and cytoplasmic proteomics uncover a nuclear pool of cytoskeletal proteins, including MAP1B, whose shuttling to the nucleus increases BRG1/BAF chromatin association and regulates brain development. Read more about this post… Credits: Source Disclaimer

Scientists have uncovered a gigantic hidden structure beneath East Antarctica, linking several enormous basins buried under miles of ice into a single fan-shaped formation stretching across the continent. Credit: Shutterstock Scientists have discovered a colossal hidden structure beneath Antarctica that could reshape our understanding of the continent’s past and present. Scientists have…

Background: Donor-derived cell-free DNA (dd-cfDNA) enables early detection and monitoring of graft injury after transplantation. However, clinical adoption has been slowed by pricing and limited reimbursement. Commercially available assays based on different methodologies are used in practice, but their comparability remains uncertain. Demonstrating interchangeability may support more…

Background: The aggressive and diverse subtype of breast cancer known as triple-negative breast cancer (TNBC) has poor clinical outcomes and few specific therapeutic choices. Tumor-infiltrating lymphocytes (TILs), T-cell receptor-engineered T cells, and chimeric antigen receptor T (CAR-T) cells are examples of adoptive cell therapy (ACT), which has become a promising immunotherapeutic approach.…

Nanomedicine has revolutionized oncology through targeted drug delivery and theranostic applications. However, its clinical translation remains a formidable challenge, primarily due to the translational gap created by conventional preclinical models. These models often fail to recapitulate patient-specific tumor heterogeneity and the complex dynamics of the tumor microenvironment. This review…

Nanomedicine has revolutionized oncology through targeted drug delivery and theranostic applications. However, its clinical translation remains a formidable challenge, primarily due to the translational gap created by conventional preclinical models. These models often fail to recapitulate patient-specific tumor heterogeneity and the complex dynamics of the tumor microenvironment. This review…

Nanomedicine has revolutionized oncology through targeted drug delivery and theranostic applications. However, its clinical translation remains a formidable challenge, primarily due to the translational gap created by conventional preclinical models. These models often fail to recapitulate patient-specific tumor heterogeneity and the complex dynamics of the tumor microenvironment. This review…

Tumor cells rely heavily on vascular nutrient supply and glucose metabolism to sustain proliferation, while maintaining redox homeostasis through reprogrammed antioxidant systems, making it difficult for single starvation therapy or chemodynamic therapy (CDT) alone to achieve durable and effective antitumor efficacy. To address these limitations, we developed a cancer cell membrane (CMC)-coated…

LEAPER 3.0, a structurally optimized dual-bulge ADAR-recruiting RNA design platform, achieves precise and efficient endogenous A-to-I RNA editing across diverse ADAR contexts. Read more about this post… Credits: Source Disclaimer