Dr Abdullah Farhan

Researchers found that the cancer-driving protein MYC helps tumors repair DNA damage and survive treatment. The discovery could lead to new ways to weaken cancers by shutting down one of their key survival mechanisms. Credit: Shutterstock Cancer’s most notorious growth protein may also be helping tumors survive chemotherapy. A protein already known for fueling cancer growth may have another…

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins. Read more about this post… Credits: Source Disclaimer

Visualization of gas flows around a binary protostar system calculated by ATERUI III. The gas shown in red orbits around one of the two protostars. The gas shown in blue orbits around the combined binary system. The gas shown in green is being expelled from the system and is carrying away angular momentum. The present research shows that the magnetic field plays an important role in expelling gas…

Cancer immunotherapy has revolutionized oncology, yet its efficacy against solid tumors remains severely hampered by the functional impairment and phenotypic skewing of immune cells within the tumor microenvironment. Here, we report a multifunctional nanoplatform that integrates potent immune reprogramming with real-time immune monitoring to enable both precise immunomodulation and dynamic…

Background: Bladder urothelial carcinoma (BLCA) exhibits heterogeneous outcomes, creating an urgent need for reliable prognostic biomarkers. Glycosylation modifications are crucial in cancer but understudied for BLCA stratification. Methods: Using clinical and transcriptomic data from The Cancer Genome Atlas (TCGA) and glycosylation-related genes from the Gene Set Enrichment Analysis (GSEA)…

Job Details This postdoctoral researcher position focuses on research on the development of polymer biomaterials for medical applications. Specifically, you will develop biomaterials such as injectable gels through polymer synthesis, gel preparation, physical property evaluation, cell culture testing, and animal experiments, with the aim of applying them to regenerative medicine and tissue…

Job Details This postdoctoral researcher position focuses on research on the development of polymer biomaterials for medical applications. Specifically, you will develop biomaterials such as injectable gels through polymer synthesis, gel preparation, physical property evaluation, cell culture testing, and animal experiments, with the aim of applying them to regenerative medicine and tissue…

Job Details This postdoctoral researcher position focuses on research on the development of polymer biomaterials for medical applications. Specifically, you will develop biomaterials such as injectable gels through polymer synthesis, gel preparation, physical property evaluation, cell culture testing, and animal experiments, with the aim of applying them to regenerative medicine and tissue…

Objectives: Malocclusion and the treatment process can affect the person’s quality of life, which includes physical and psychological effects. Classifying the patient accurately is critical to achieving the desired output. This study aimed to improve the current diagnostic process with artificial-intelligence algorithms using the lateral cephalogram. Materials and methods: The study sample…

Taczanowskia waska, the newly discovered spider species. Credit: Díaz-Guevara Scientists have discovered a new spider species in Ecuador’s Amazon rainforest that uses an unprecedented form of mimicry. Deep in Ecuador’s Amazon rainforest, researchers encountered what appeared to be an ordinary mushroom clinging to the underside of a leaf. On closer inspection, however, the strange growth revealed…

New York University (New York, NY) Read more about his post… Credits: Source Disclaimer

Background: Neuroendocrine prostate cancer (NEPC) is an aggressive, treatment-refractory state that often emerges under androgen-receptor pathway inhibition. We hypothesized that dysregulated ubiquitination underpins NEPC lineage plasticity and that integrating bulk and single-cell transcriptomes would define a ubiquitination-centered signature and tumor microenvironment (TME) circuits of…

Background: Neuroendocrine prostate cancer (NEPC) is an aggressive, treatment-refractory state that often emerges under androgen-receptor pathway inhibition. We hypothesized that dysregulated ubiquitination underpins NEPC lineage plasticity and that integrating bulk and single-cell transcriptomes would define a ubiquitination-centered signature and tumor microenvironment (TME) circuits of…

Background: [¹⁸F]FDG PET/CT can be used to diagnose suspected new-onset giant cell arteritis (GCA), but it is unclear, whether visual or semiquantitative evaluation yields the highest accuracy. We therefore aimed to compare both methods with regard to diagnostic accuracy within the same patient. Methods: This single centre study included all ≥ 50 year-old patients undergoing [¹⁸F]FDG PET/CT…

Type: Full-Time Posted: 1 day ago Application Due: Open Until Filled Category: Faculty Affairs The Director of Faculty Development and Calibration provides leadership in planning, implementing, and evaluating faculty development initiatives and faculty calibration processes within the predoctoral dental program. This position promotes excellence in teaching, consistency in clinical…

Larkin University -School of Dental Medicine (Winter Garden, FL) Read more about his post… Credits: Source Disclaimer

Gut dysbiosis-driven macrophage polarization plays a critical role in the pathogenesis of ulcerative colitis (UC). Dipsacoside B (DB), a natural saponin, possesses potential anti-inflammatory properties; however, its influence on mucosal immunity and the gut microbiota remains to be elucidated. To evaluate the therapeutic effects of DB, this study employed a DSS-induced colitis model in C57BL/6…