Clostridioides difficile

Clostridioides difficile (CD) is a leading cause of antibiotic-associated diarrhoea in both hospitalized and non-hospitalized patients. This study explores the role of extracellular vesicles (EVs) derived from Clostridioides difficile strain 630 (CD630-EVs), which released spherical EVs during in vitro culture, in modulating pro-inflammatory cytokine production in macrophages. Proteomic analysis…

Theriot, C. M. et al. Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection. Nat. Commun. 5, 3114 (2014). Article  PubMed  Google Scholar  Dubois, T. et al. A microbiota-generated bile salt induces biofilm formation in Clostridium difficile. npj Biofilms Microbiomes 5, 1–12 (2019). Article  Google Scholar  VanInsberghe,…

Inflamed environment is Clostridioides difficile paradise

A medical illustration of Clostridioides difficile bacteria, formerly known as Clostridium difficile, presented in the Centers for Disease Control and Prevention (CDC) publication entitled, Antibiotic Resistance Threats in the United States, 2019. Credit: CDC A new study from North Carolina State University shows that the inflammation caused by Clostridioides difficile (C. diff) infection gives…

Advance in search for new Clostridioides difficile vaccine — ScienceDaily

Scientists have made a breakthrough in the hunt for a new vaccine for killer hospital bug Clostridioides difficile (C. diff).

University of Exeter researchers first identified a gene in C. diff responsible for producing a protein that aids in binding the bacteria to the gut of its victims.

In collaboration with researchers at Paris-SUD University, they then showed that mice vaccinated with this…