#cellderived

The poor immunogenicity of many tumours results in part from their downregulation of the antigen processing and presentation (APP) machinery, including MHC molecules, in both tumour cells and tumour-associated dendritic cells (DCs). Extracellular vesicles (EVs) — membrane-bound nanoparticles released by living cells that contain protein, lipids and nucleic acids — have been shown to facilitate…

The poor immunogenicity of many tumours results in part from their downregulation of the antigen processing and presentation (APP) machinery, including MHC molecules, in both tumour cells and tumour-associated dendritic cells (DCs). Extracellular vesicles (EVs) — membrane-bound nanoparticles released by living cells that contain protein, lipids and nucleic acids — have been shown to facilitate…

Nature Immunology, Published online: 08 September 2025; doi:10.1038/s41590-025-02263-y Erlich et al. show that soluble LTα and membrane-bound LTα1β2 lymphotoxins expressed by B cells play distinct roles to attenuate the pathology observed in ileitis. Summary Erlich et al. in Nature Immunology (September 2025) reveal that B cell-derived lymphotoxins, specifically soluble LTα and membrane-bound…

Science, Volume 389, Issue 6760, August 2025. Summary Without specific content from Science, Volume 389, Issue 6760, August 2025, I can only provide a general summary. This issue of Science likely features cutting-edge research articles, perspectives, and reviews across various scientific disciplines, including biology, physics, chemistry, earth science, and potentially emerging fields. Expect…

Pancreatic β cell-derived exosomal miR-29 family enhances hepatic glucose output

Credit: CC0 Public Domain In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang’s group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig’s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs). Theses β cell-derived exosomal miR-29s…

NIH offers grant to examine potential of stem cell-derived cardiac cells for heart disease treatment

July 3, 2018

Examining the treatment potential of cardiac cells derived from human pluripotent stem cells (hPSCs) may lead to dramatically altering the care of cardiac disease and heart injuries, thanks to a grant from the National Institutes of Health.

The focus of a three-year, $567,000 Trailblazer Award grant from NIH’s National Institute of Biomedical Imaging and Bioengineering, this…