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Multiphoton fluorescence image of HeLa cells with cytoskeletal microtubules (magenta) and DNA (cyan). Nikon RTS2000MP custom laser scanning microscope.
Source: National Center for Microscopy and Imaging Research (NCMIR) (source)
Credit Line: National Center for Microscopy and Imaging Research
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CALB2 mediates tumor progression and immune escape in colorectal cancer by shaping an inhibitory immune microenvironment - Research
Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, characterized by a highly immunosuppressive tumor microenvironment (TME) that facilitates immune evasion and tumor progression. Methods: Integrated analysis of TCGA and GEO datasets was performed to evaluate CALB2 expression and its prognostic significance in CRC. Functional experiments including…
Targeting IL-7Rα with PNU-159682 antibody-drug conjugates in acute lymphoblastic leukemia: translational implications - Research
Relapsed acute lymphoblastic leukemia (ALL), particularly with central nervous system (CNS) involvement, remains a major cause of treatment failure and is inadequately controlled by existing antibody-drug conjugates (ADCs) with tubulin inhibitors. To address this limitation, we developed IL-7Rα-targeted monoclonal antibodies and identified clone 577 as the lead candidate. Using this antibody, we…
Prognostic Stratification and Subtyping of Glioblastoma Using Transient Receptor Potential Channels - Research
Background: Transient receptor potential (TRP) channels regulate Ca2+ homeostasis and tumor malignant phenotypes, whereas their prognostic relevance and therapeutic implications in glioblastoma (GBM) remain poorly characterized. Methods: We curated a comprehensive compendium of 522 TRP-related genes from MSigDB, KEGG, and GeneCards. Differential expression analysis across clinical variables in…
Low-dose dihydroartemisinin resensitizes lung cancer cells to cisplatin by suppressing interleukin-6 release by macrophages - Research
Background: The clinical application of dihydroartemisinin (DHA) is limited by its pharmacokinetic profile, making high in vitro concentrations clinically unattainable. Its effects at physiologically relevant low doses, especially in the complex tumor microenvironment (TME), are poorly understood. Objectives: This study investigated how clinically attainable low-dose DHA affects the efficacy…
Anya is live and ready to show you everything. Watch her strip, dance, and perform exclusive shows just for you. Interact in real-time and make your fantasies come true.
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Foslip-Mediated Photodynamic Treatment Reprograms Macrophages Phenotype in Tri-Culture Head and Neck Cancer Spheroids - Research
Background: The tumor microenvironment (TME) composition is among the critical events leading to the poor prognosis of head and neck cancers. TME includes immune cells, tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAF), and other non-cancerous cells, which contribute to therapeutic outcome. The heterogeneity of the TME offers a multitude of potential targets for…
SLC12A7 serves as a prognostic and immunotherapeutic biomarker identified by multi-omics analysis - Research
Background: Solute carrier family 12 member 7 (SLC12A7) is a membrane transporter implicated in ion homeostasis. Recent studies have suggested its aberrant expression in various malignancies; however, its functional roles and clinical relevance across cancers remain poorly defined. Given the limited understanding of SLC12A7 in oncogenesis and the urgent need for novel biomarkers, particularly in…
Discovering the abnormalities and functional importance of ferroptosis-related molecules in cervical cancer - Research
Ferroptosis is an iron-dependent nonapoptotic form of cell death that links iron, lipid, and glutathione levels to a variety of disease-related activities. However, the characteristics of ferroptosis in cervical carcinoma (CC) are poorly understood. We acquired raw data on CC cohorts from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. Key genes were identified…
