#multiomics

Making Bones

A atlas of human embryonic skeletal development between 5 and 11 weeks after conception created by modelling the gene activity and epigenetic data from single cells, as well as the cell spatial localisation – a multi-omic approach. Insight into cell fate determination during development and mechanisms of disease, such as osteoarthritis

Read the published research article here

Image from work by Ken To, Lijiang Fei and J. Patrick Pett, and colleagues

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature, November 2024

More Than Immunity

As skin develops before birth it's rich in innate (a first response, rather than an adapting form of defence) immune cells, including macrophages. By creating a reference atlas of pre-natal human skin (7–17 weeks post-conception), combining single-cell and spatial transcriptomics (locating active genes) data, this study finds that macrophages play a role beyond providing immunity, driving the development of vessels in the skin

Read the published research article here

Still from video from work by Nusayhah Hudaa Gopee, Elena Winheim and Bayanne Olabi, and colleagues

Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK

Video originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)

Published in Nature, October 2024

Malignant Memoir

Using single-cell and spatial (across the tumour tissue landscape) multi-omics (including profiling the genome and gene activity) – to map the evolution of colorectal cancer and its microenvironment simultaneously as the disease progresses. Insight for stratifying disease type and treatments

Read the published research article here

Image from work by Cody N. Heiser and colleagues

Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA

Image originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)

Published in Cell, December 2023

Stellaromics today launched Pyxa™, the first commercially available platform to deliver multiplexed 3D spatial transcriptomics in intact tissue up to 100 micrometers thick. The launch marks a fundamental shift in spatial biology — from 2D thin-section approaches that analyze partial cell layers to true 3D analysis that preserves the native organization of cells, molecules, and…

Sapio Sciences, the science-aware™ lab informatics platform, today announced a strategic partnership with Ultima Genomics. The collaboration will make multi-omics workflows more accessible and streamlined for researchers by integrating Sapio’s AI-powered lab informatics solutions with Ultima’s high-throughput, low-cost sequencing platform. Together, the companies will deliver efficient,…

This study explores the genetic and molecular connections between Chronic Obstructive Pulmonary Disease (COPD) and Abdominal Aortic Aneurysm (AAA). Using a multi-omics approach—combining genomics, transcriptomics, and epigenetics—the research identifies shared biological pathways and potential biomarkers. The findings offer new insights into the overlapping mechanisms of these two conditions and open doors for targeted therapies.