#autoantigen

Objective: To identify HLA associations with clinical and autoantibody-defined subgroups of idiopathic inflammatory myopathy (IIM) and predict potential immunogenic epitopes presented by subgroup-specific HLA alleles. Methods: An observational case-control study was conducted including 147 biopsy-confirmed IIM patients and 114 ethnically matched healthy controls. Patients were classified into…

Objective: To identify HLA associations with clinical and autoantibody-defined subgroups of idiopathic inflammatory myopathy (IIM) and predict potential immunogenic epitopes presented by subgroup-specific HLA alleles. Methods: An observational case-control study was conducted including 147 biopsy-confirmed IIM patients and 114 ethnically matched healthy controls. Patients were classified into…

Objective: To identify HLA associations with clinical and autoantibody-defined subgroups of idiopathic inflammatory myopathy (IIM) and predict potential immunogenic epitopes presented by subgroup-specific HLA alleles. Methods: An observational case-control study was conducted including 147 biopsy-confirmed IIM patients and 114 ethnically matched healthy controls. Patients were classified into…

Salmonella-based oral vaccine for T1 diabetes successful in animal model. Thoughts health innovators?

Type 1 diabetes is an autoimmune disease, meaning that the underlying problem is with the immune system.  It is still unclear as to why the body’s immune system attacks and destroys the part of the pancreas that produces insulin,  resulting in a loss of metabolic control and high blood sugar levels.  Earlier studies have investigated inhibiting all immunity in type 1 diabetes and have shown good…

Researchers identify previously unknown class of antigen present in T1 diabetes. Thoughts health innovators?

Type 1 diabetes is the autoimmune form of diabetes, in which insulin-producing beta cells in the pancreas are destroyed by immune cells, especially those known as T cells.  Insulin is the hormone that regulates levels of glucose in the blood and without insulin, a life-threatening disease results. Currently, there is no cure for type 1 diabetes.  Now, a study led by researchers at the University…