Age-related decline in NCKX4-mediated calcium clearance accelerates aortic remodelling and drives early vascular ageing - Research
Ageing is the primary non-modifiable risk factor for cardiovascular diseases (CVDs), with older women facing a greater risk of CVDs than age-matched men. Vascular smooth muscle cells (VSMCs) dysfunction and impaired calcium (Ca2+) handling are recognized as central contributors to arterial stiffening and vascular calcification. However, the molecular and functional determinants of Ca2+ clearance…




















