Angelic Androgyne

Like, the overwhelming majority of the mechanics of that genre would lend themselves absolutely perfectly to that. The tank controls early in the genre? character handling and turning their chair. The oft-joked part of you can't climb over knee-high obstacles? Well, yeah, even if the protagonist has enough mobility to stand and climb over, unless they can get their chair through with them they're out of luck. The often semi-cumbersome relationship with melee weaponry and use of firearms? A wheelchair user is someone who would have even more reasons to not want a demon from hell practically on top of them- both their body and their primary means of mobility is at risk.

Heck, Silent Hill even loves scattering wheelchairs around and using them as imagery anyway, just put the playable character in one.

Even the way these sort of games often herd and control the player character's movement through the setting, and how they have to solve puzzles to progress- that would have perfect intertextuality with someone who's not just lost in the middle of nowhere but also has to figure out how to, say, get up to a second floor of a space that doesn't have an elevator and they can't climb the stairs.

I know the game Endoparasitic has a protagonist with only one working limb as its central conceit but as-said it baffles me how few games feature mobility-limited protagonists when so many genres but especially survival horror feel like they'd lend themselves perfectly to that sort of thing.

Almost every survival horror concerns itself at least partially with navigating an environment that seems set against you and often having to specifically solve problems to get place to place in crumbling environs.

and if that meager warmth could carry you through just one cold night

then maybe God would grant me the respite