kill donald trump

Like I only just started paying attention to how antiblack things are and I caught something that I know literally no one else around me has caught the antiblackness of because it has enough plausible deniability for people to not see the racism and it’s driving me nuts. (Not going into detail because it sucks and you don’t need MORE racism added to your life)

And you’re dealing with this your whole fucking life! That’s not fair. I hope you get some peace. You’ve deserved it all this time and you’re owed it.

but the insults directed at the black crits are all racially charged. i do not need to point out the irony in calling the black fans racist because they're pointing out Goose's repeated racism

and if you ever call them out for it, they're going to excuse it because they're neurodivergent or their great great great great great great great great great grandparents were indigenous or they have black friends or they're queer or whatever

it is literally these images. if you're mature enough to be racist, you're mature enough to be able to handle criticism of your favorite show or your favorite character. you're mature enough to block the tag and move on if you disagree

@velvetdemon I'm doing a full reply because I want to give this question the time and space it deserves, and I really do appreciate your curiosity about this.

The short answer: It is deeply unethical. There are nowhere near enough willing patients in the world to be able to do this, and it would be criminal to put them through this.

The long answer: The one side of the equation you're focusing on is: how much of a drug is too much, to the point where it will cause negative side effects or even death? And this is crucial to know. But it's not just a matter of finding out the lethal dosage of a heart cholesterol medication, you need to know that it can actually lower the cholesterol of any living thing. There is no way to know this without giving it first to...a living thing.

But beyond this, I need to emphasize: The goal of a drug trial is to effectively cure people who are already suffering from disease, who are living on limited time.

Drug trials don't just happen on any member of the public, they need to happen specifically on people affected by the disease you're trying to treat. There is at any time a very limited and very marginalized population of the world affected by early onset, familial Parkinson's disease. Because you cannot ethically induce disease in a human being, you are working with, speaking with, and helping patients and their families who are hopeful and desperate for a cure.

If you were to jump straight to human trials from petri dishes, not knowing absolutely anything about how the drug functions in a living, breathing animal body, it would look like this:

We didn't know that minute quantities of the drug interact lethally with x, y, z medication that people are commonly also taking. X number of patients have died as a result.

We didn't know that the drug is fatal to people with [common variant] in their genetics. X more patients have died.

We didn't know the drug exacerbates x, y, z chronic illnesses. X number of people have acquired permanent, lifelong disabilities.

We didn't know the best way to deliver the drug, so we tried multiple ways: the people who received it intravenously are now suffering from a painful, costly, and debilitating condition that did not happen with the ingested form.

I could go on, and on, and on.

The vast majority of these problems can be nearly or almost entirely averted by testing other animals first.

These are all people who possibly could have waited for the normal progression from animal testing to human testing and thus received better outcomes. Some people will pass away in the time it takes to get to that point, and that's heartbreaking, and we all wish science could be faster.

animal research is not the mad scientist wild west that PETA wants you to think it is. there are extremely strict federal laws in place to protect the well being of these animals. animal welfare organizations like AAALAC ensure that lab animals are treated with dignity & respect and are given enough specialized care & enrichment to be happy and content in captivity, just like AZA accreditation with zoos.

not a single animal from a zebrafish to a mouse to a dog to a macaque goes unaccounted for. if an animal gets moved to a new cage, paired for breeding, has a procedure performed on it, gives birth, gets sick or injured, dies, etc. it is legally required that this information is recorded and kept on file for the US federal government to access. failing to record & retain this information is very much punishable by US federal law.

let me tell you - if you abuse or kill an animal, even a mouse - you are almost certainly getting both fired & blacklisted from the industry. if you abuse or kill a more ‘advanced’ animal, such as a dog or monkey, you will likely face criminal charges. killing a monkey is as serious and disastrous as a nuclear meltdown. you are expected to reasonably explain every illness, injury, or death of an animal under your care. you must record all of this information. animals that are clearly suffering with low QOL are required to be euthanized according to AVMA guidelines.

research animals are highly expensive. yes, even the "lesser" animals like mice. the cheapest mice will run you a few hundred $ per individual, with some of the most expensive mice i've cared for being $25,000 per individual. in research we have the "three Rs" - reduction (reduce amount of necessary animals to a minimum), refinement (refine processes to ensure research is accurate and animals feel no pain or distress), and replacement (replace animals with non-living research models as they become available). i can assure you no proper research team is wasting animals (*do not* say "b-b-but elon musk--" his research team is actively being investigated for animal abuse by the government).

research methods that do not require live animals are currently being looked into & efforts spearheaded by - you guessed it - the animal research industry itself (notice how the animal rights people are strangely silent & unhelpful when it comes to this?) but current technology is rudimentary and does not compare to live animal models.

some research animal fun facts (US edition):

all species of animals are only allowed to have one single major surgery performed on them in their entire lifetime.

institutions with nonhuman primates must have a behavior program in place (run by knowledgeable primate specialists) to ensure that they are happy and receiving enough daily enrichment and social interaction.

institutions with dogs are required to have physical exercise programs in place. this means every individual dog gets a substantial amount of leashed AND free-roaming exercise daily, including playgroups with other dogs.

a majority of nonhuman primates get to retire to sanctuaries like peaceable primate sanctuary, and almost all dogs get retired and adopted out by organizations like homes for animal heroes. some institutions will also adopt out unneeded young rabbits, guinea pigs, rats, etc.

some strains of mice glow neon green (or orange or blue) under UV light. this is not harmful to them and is commonly seen in cancer research.

At the moment, this is not a substitute for animal testing. Bodies are incredibly complex and interconnected environments that we're still scratching our heads about, and animal testing is in a lot of ways the most efficient and least harmful way of testing things like medications.

If anyone wants to read more about these subjects, here are a few starting points (you will probably learn some new words, this is okay!):

Advances and Applications of Predictive Toxicology in Knowledge Discovery, Risk Assessment, and Drug Development research topic by the Frontiers in Pharmacology journal

Novel methods and technologies for the evaluation of drug outcomes and policies research topic by the Frontiers in Pharmacology journal

Spotlight on Artificial Intelligence in Experimental Pharmacology and Drug Discovery research topic by the Frontiers in Pharmacology journal

The Emerging Discipline of Quantitative Systems Pharmacology research topic by the Frontiers in Pharmacology journal

PDF Drug Combinations: Mathematical Modeling and Networking Methods by Vahideh Vakil and Wade Trappe

PDF Machine learning-based drug-drug interaction prediction: a critical review of models, limitations, and data challenges by Flaviu-Ioan Gheorghita et al.

PDF A review of 3D bioprinting for organoids by Zeqing Li et al.

3D Bioprinting for Engineering Organoids and Organ-on-a-Chip: Developments and Applications by Yuqing Ren, Congying Yuan, et al.

3D bioprinting of human iPSC-Derived kidney organoids using a low-cost, high-throughput customizable 3D bioprinting system by Jaemyung Shin, Hyunjae Chung, et al.

One of the strangest Roblox bugs of all time in my opinion is this one recorded by Hackerhunter100, in November 2009. "whenever you play roblox and spore at the same time the files mix and everything glitches"

twitter user wiredmjx also left a technical explanation in the comments as to why this could happen

Remarkable rendering bug. It's caused by two processes: XPDM (basically the thing that manages WinXP graphics) and DirectX 9. Essentially, XPDM allows both Spore and Roblox to access the same memory, while DX9 was a lot more lax with how it handles reading & writing memory. 1/x First, Spore writes its graphics into the memory, the specific image you're seeing in Roblox is the depth buffer (which is a greyscale image that indicates how close objects are to the camera). Roblox then asks for some memory to write its own graphics (a cubemap skybox) to. 2/x DX9 hands over that memory WITHOUT CLEARING IT because it expects the programmer (whoever wrote the Roblox renderer) to do so. Roblox however also fails to clear that memory. It uses data still in that memory block (Spore's depth buffer) and puts it on the cubemap. 3/x Now, the Roblox renderer doesn't know whether this is valid data or not, it doesn't check at all what the data is. The remarkable part is that it just so happens it IS valid data! So instead of getting a crash, you get this Spore monster in the skybox :) 4/x This bug was likely fixed around 2010 with the Roblox renderer now correctly clearing the skybox cubemap texture memory prior to use. This kind of issue is now extinct on modern computers, as the modern equivalent of XPDM doesn't let programs access eachothers memory anymore. 5/5

other people in the comments have struggled replicating this same bug from what i saw, but other people have reported that this happened to them as a kid

it also seems like textures got carried over bertween the two. spore had these weird graphical issues (left i stretched back into shape but i cant tell what this is)

and theres some ui elements here in roblox. this appears to be graphics_atlas~/NoGroup_ScrollFrameVerticalGeneric-00.png