Second time I've heard about diy being safer, so, in what way (s) is non-diy dangerous?
pedantic, but the claim wasnt that diy is safe, wasnt that it is "safer", but in many ways it is.
doctors are often (read: almost always) uneducated on transgender health. from Continuing Gaps in Transgender Medicine Education Among Health Care Providers "few of [the endocrinologists] (11%) rated themselves as very compotent in transgender care. Consistent with their self report, only 5% correctly answered knowledge questions. Further, only 36% reported training in transgender care during endocrinology fellowship."
because of this, trans women are often prescribed doses of estrogen so low as to have very little feminizing effect. for example, the common dosing of 2mg daily estradiol tablets with 50mg daily spironolactone is generally not enough estrogen to dominate a woman's endocrine system, but is enough to strongly weaken her testosterone, which is likely to cause harm (your body needs a dominant hormone, it doesn't care if it's estrogen or testosterone, but not having either is directly dangerous). these doses also fail to meaningfully decrease risk of depression and its symptoms (self harm, suicide, etc).
in a deeply transphobic world, where trans rights are constantly under massive threat, anything which can give care to trans women is imperative to their safety.