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Occasionally you do need to just let fantasy be fantasy. "Why are the mountains around Mordor in a square, mountain ranges don't work like that" well you see there's an evil god who lives there hope this helps
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i think we should be talking about the semi-recent advancements in cystic fibrosis treatment like all the time every day. there hasn’t been a drug like this since AZT medications for HIV infection it is truly fucking miraculous and very important
basically: cystic fibrosis is a genetic disease which makes the mucous a person generates extra sticky. it used to kill people in infancy, then with advancements in medical tech it killed people in young childhood, and until very recently cystic fibrosis patients could expect to live until about thirty years old with consistent painful lung infections and complications.
in 2019 the FDA approved a drug called trikafta (which is really three drugs in one) for cystic fibrosis treatment. what it essentially does is patch up the malfunctioning proteins that cause the extra sticky mucus. trikafta is effective on about 90% of cystic fibrosis patients.
people who had spent their entire lives in and out of hospitals, on and off of ventilators, suffering from pneumonia and sometimes treated through painful procedures like intubation took this drug, got out of bed, coughed up an entire lifetimes worth of mucus out of their lungs over the course of a few hours, breathed clearly for perhaps the first time in their lives, and now go on to live well into their seventies.
like isn’t that insane. isn’t that amazing. doesn’t that give you hope for the future of medical advancements and treatment. fuck. i think about it all the time……
For the people asking "well how do we know people are living that long if it's so new????" Here's a page from the CF foundation about life expectancy.
Additionally, it should be noted that metrics like life expectancy are in no way a guarantee of... Anything. There are significant outlier CF patients who are at an advanced age now despite the odds due to a variety of different factors, having lived the majority of their lives before the development of modulators.
But the fact remains that the odds are better now than they have ever ever been before, by leaps and bounds. It isn't cured, and many patients still need significant treatment in addition to Trikafta, but it is so much better than anyone could have dreamed of twenty years ago, and that is a triumph.
Yes! My sister has a serious form of cf and finally is living a more comfortable and active life. She was also part of many of the clinical trials leading to these breakthroughs due to the nature of her cf. It's been very exciting to see.
That's absolutely incredible. Don't get me wrong. It's miraculous from a clinical standpoint. But, uhh. Not to be a downer but I need people to see this so they stay angry and stay real about what medical breakthroughs actually mean for patients. When I call something "survival gatekeeping", this is what I mean:
That is per month with the most common coupon people are likely to use.
But don't worry, there's grants and patient assistance programs you can apply for. 🤞🫠 Most people in high income countries like the USA can get it "covered" through insurance for fewer thousands of dollars. Or even less if your insurance is good or the manufacturer likes how poor and/or on Medicaid you are! A good social worker will help you with the process, and make sure your yearly reapplications and PAs are done a little early so they have time to think about it before you run out. Jesus Christ.
NEVER look at something like this and navigate away feeling better about things without asking how much it costs and who can get it. NEVER. It isn't revolutionary until poor people can access it without a struggle.
I don't know how to articulate this well, but I really fucking hate the way a lot of thin writers write fat characters. Like how men write women "breasting boobily" there is something so dehumanizing about how fat characters are often written. "He waddled", "he lumbered", the writer of the book I'm reading always mentions this characters "fleshy hand" when he does something with his hand. Like, we already know that he's fat. There is no need to describe everything he does as "doing it fatly".
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a non definitive guide to markiplier x ryan gosling ships
with both of these coming from very different spheres of the internet, there are a lot of people who are only familiar with one of their respective filmographies, or even not familiar at all barring recent releases. if you've been seeing different markiplier characters get shipped with different ryan gosling characters, and wanted to know what that was all about, here is a list with everything I have seen so far and as many links as possible. a lot will be links to the one or two posts that make up the entire content for that fandom since none of these are anywhere near as big as bloodymary.
bloodymary - simon/ryland grace
-> simon (also known as the convict or the butcher) from the movie iron lung (2026)
-> ryland grace from the movie project hail mary (2026)
#bloodymary on tumblr - one of the earliest tumblr posts made about it - ao3 tag
discodoll - warfstache/ken
-> wilford warfstache from who killed markiplier? (2017)
-> ken from the movie barbie (2023)
#discodoll on tumblr - the first/most popular/only (so far) tiktok post about them
stuntstar - actor mark/colt seavers
-> actor mark from who killed markiplier? (2017) (and more)
-> colt seavers from the movie the fall guy (2024)
#stuntstar on tumblr - the first tiktok edit - another one
spacestunt - head engineer mark/colt seavers
-> head engineer mark from in space with markiplier (2022)
-> colt seavers from the movie the fall guy (2024)
#spacestunt on tumblr
projectspace - head engineer mark/ryland grace
-> head engineer mark from in space with markiplier (2022)
-> ryland grace from the movie project hail mary (2026)
one edit - second edit - third edit - ao3 tag
heistdrive / drivebyheist - yancy/"the driver"
-> yancy from a heist with markiplier (2019)
-> "the driver" from the movie drive (2011)
#drivebyheist on tumblr - the only edit (here they're heistdrive, ship too small for an established name #dope)
[name still undecided] - yancy/sebastian wilder
-> yancy from a heist with markiplier (2019)
-> sebastian "seb" wilder from the movie la la land (2016)
the edit (based on comments suggesting it) - some proposed names are jazzheist, jazzjail, jailhouse jazz
other proposed ships without names/posts:
illinois from a heist with markiplier (2019) and
holland march from the movie the nice guys (2016)
-> proposed as a ship here
darkiplier from who killed markiplier? (2017) (and more) and
henry letham from the movie stay (2005)
-> proposed as a ship here
darkiplier from who killed markiplier? (2017) (and more) and
officer k from the movie blade runner 2049 (2017)
-> proposed in the bloodymary discord and here (in the comments)
actor mark from who killed markiplier? (2017) (and more) and
ken from the movie barbie (2023)
-> proposed as a ship here
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in the future humans will have something called "sinus button " and pressing it will immediately drain your sinuses of all fluid so that it can be filled with other things like rocks, webs, paint, tar, freef (new fluid that will be so important in that time) and also dr papper
I am rewatching E.T. for the first time in over ten years. I was not prepared for the visual introduction of E.T. and his human teeth.
I thought this was a classic Spielberg movie about the devoted friendship between a human boy and an alien. This E.T. is abhorrent to me. I hate the visible moistness of his skin and how he moves with slow and careful intent.
It's been so long since I watched this that it may as well be my first time. My guess is that E.T.'s whole town ditched him because he is an unsettling weirdo.
I'm likely going to keep talking about this. I am ET-posting. He extends his neck like the Eraserhead baby. I have no love in my heart for him and neither does God. He is an Opp to me.
Spielberg is a strange director. It's wrong to say he's sanitized for mass consumption as a filmmaker. He makes some odd creative choices. I don't think it's a Normie Filmmaker move to try and push for a B-Plot where E.T. has some kind of romance arc with Elliot's mom. That is a baffling creative choice.
He makes movies with like a handful of really incredible shots tied together with nonsense either Inconsequential or Weirdly Horrific. In a way I get why he decided to collab with Tobe Hooper to make Poltergeist. He's got a weird flare for the disturbing for such a family-friendly director.
So like. I misremembered E.T. as being about a baby alien who needs help being reunited with his alien mom.
Turns out that is uh. Not ever stated to be a thing in the movie at all? And according to the 1982 novelization, E.T. is a ten million years old biologist. I have not read the book. I am going to order a copy of eBay because of course I am.
But E.T. being a biologist implies, to me, a degree of intent that gives a menace to a lot of his behaviors in the film.
If he's a baby alien, him fucking around on Earth and like psychically imprinting on Elliot is more understandable. He's a kid, he doesn't know what's happening. But if he's a scientist who came to study Earth, he suddenly becomes a way more sketchy guy to me.
I want a sequel of E.T. where Elliot is a grown man. A father, maybe. And he's just starting to come to terms with how an alien tried to murder-suicide and abduct him as a kid.
Like a Doctor Sleep situation. I haven't read Doctor Sleep but I bet it would be something like that.
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