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@mediamed
Herz mit vierfachem Bypass (Heart with quadruple bypass), Foto: Christoph Weber. From the Berlin Museum of Medical History at the Charité
Herz mit vierfachem Bypass (Heart with quadruple bypass), Foto: Christoph Weber. From the Berlin Museum of Medical History at the Charité
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Les auteurs d’une étude ont envisagé de réduire le seuil transfusionnel de 8 g/dl à 7 g/dl d’hémoglobine en cas de chirurgie orthopédique. MediaMed Information
Vers une diminution du seuil transfusionnel au bloc opératoire ?
Alors que des recommandations précises encadrent la prescription de produits sanguins labiles dans les services de médecine traditionnelle, la question du seuil transfusionnel en situation aiguë reste posée.
En considérant, par exemple, la chirurgie orthopédique, souvent décrite comme une chirurgie à risque hémorragique potentiellement important [...]
Crédit image : Iroises communication
Dans le cadre de cette étude rétrospective monocentrique, 1 507 patients ont été inclus entre janvier 2013 et décembre 2014 (pre-patient blood managment : seuil transfusionnel à 8 g/dl d’Hb), puis 2 402 patients entre janvier 2015 et mai 2017 (seuil transfusionnel à 7 g/dl d’Hb). [...]
Lire l’article : MediaMed
Paul Desforges 07 04 2019
Source
Gupta PB, et al. Patient Blood Management Program Improves Blood Use and Clinical Outcomes in Orthopedic Surgery. Anesthesiology. 2018 Dec;129(6):1082-1091.
Voir aussi : Culots globulaires : une prescription encadrée
Internal organs getting exercise. Desbonnet system of physical culture. n.d.
Wellcome Collection
Internal organs getting exercise.
Desbonnet system of physical culture. n.d.
Wellcome Collection
Via nemfrog
The circulatory system. 1837.
Wellcome Collection
The circulatory system. William Fairland, 1837.
Wellcome Collection
Via nemfrog
Dissection of the abdomen and thigh. 1851.
Wellcome Collection
Dissection of the abdomen and thigh.
Joseph Maclise, 1851.
Wellcome Collection
Via nemfrog
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A figure with a skeleton skull mixes drugs in a pharmacy. The Antikamnia calendar for 1900. c. 1899. Page detail.
Wellcome Library
A figure with a skeleton skull mixes drugs in a pharmacy.
The Antikamnia calendar for 1900. c. 1899. Page detail.
Wellcome Library via nemfrog
Clinical Trial to Investigate whether Hypertension Drug Ameliorates COVID-19 Severity
ACE inhibitor drugs like Ramipril are widely used for various cardiovascular conditions; researchers want to see if they might also provide benefit to patients infected by SARS-CoV-2
Researchers at University of California San Diego School of Medicine have launched a clinical trial to investigate whether a drug approved for treating high blood pressure, heart failure and diabetic kidney disease might also reduce the severity of COVID-19 infections, lowering rates for intensive care unit admissions, the use of mechanical ventilators and all-cause mortality.
The trial will be randomized, double-blind and placebo-controlled, the gold standard for clinical trials. It will involve multiple sites, with the University of California San Diego as coordinating institution. Up to 560 participants will be recruited, either presenting with COVID-19 symptoms at emergency departments or currently hospitalized with the disease caused by the novel coronavirus, SARS-CoV-2. The trial is expected to run one year.
“There are no approved, proven treatments yet for COVID-19, which has infected millions worldwide and killed nearly 200,000, with the end of the pandemic nowhere in sight,” said the study’s principle investigator Rohit Loomba, MD, professor of medicine and director of the NAFLD Research Center at UC San Diego School of Medicine. “We’re investigating whether drugs called ACE inhibitors might be part of the remedy.”
Gotta love old medical ads! This example (VC070005b) lurks within our Visual Collections. We have to say that Sapanule sounds extremely impressive - just look at everything it can cure!
Les patientes ont reçu aléatoirement un traitement par contraception combinée orale ou un placebo MediaMedG : Gynécologie-obstétrique
PILULE ET SEXUALITÉ
Existe-t-il une baisse du désir ?
A l’heure où la contraception combinée orale reste le moyen de contraception hormonale le plus répandu dans le monde, ses retombées sur la sexualité féminine sont une question persistante ; il existe peu d’études, essentiellement observationnelles.
Crédit image : Iroises communication
Dans le cadre de cet essai randomisé multicentrique en double aveugle versus placebo, 202 femmes, entre 18 et 35 ans, ont été recrutées entre septembre 2013 et mai 2015, dans plusieurs centres suédois.
Évaluer les effets sur la sexualité féminine d’une contraception combinée orale
Les patientes ont reçu aléatoirement [...]
Lire l’article - MediaMed
Marion Aupomerol 31 mars 2019
Lundin C, et al. Sexual function and combined oral contraceptives: a randomised, placebo-controlled trial. Endocr Connect. 2018 Sept 1; 10.1530/EC-18-0384.
Voir aussi : Contraception hormonale et cancer du sein : une question d'actualité
Exercise versus no exercise for the occurrence, severity, and duration of acute respiratory infections. CD010596. https://bit.ly/2xOy9NU
Via cochraneblogshots
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Tested and Testing: UC San Diego Health Expands COVID-19 Diagnostics
UC San Diego Health makes measurable progress addressing COVID-19 testing shortage through multiple partnerships and rapidly growing in-house testing. Success has meant more testing for more patients, first responders and other health systems.
“I think we’re getting to the point, with our increasing testing capacity, that we can start figuring out how to use testing as a weapon to reverse the pandemic,” said Steve Gonias, MD, PhD, chief of pathology services for UC San Diego Health and chair of the Department of Pathology at UC San Diego School of Medicine. “More test results will start to create a clearer picture of what we want to do next, what we want to happen next.”
Tested and Testing: UC San Diego Health Expands COVID-19 Diagnostics
Un essai français pour tenter de mieux définir le délai d’instauration d’une épuration extra-rénale en situation de choc septique avec une insuffisance rénale aiguë. MediaMed Information
Choc septique : quand dialyser ?
L’insuffisance rénale aiguë est l’une des complications les plus fréquentes mais aussi les plus graves des patients hospitalisés dans un service de réanimation pour prise en charge d’un choc septique.
Crédit image : Piron Guillaume
[...] Dans le cadre de cet essai français multicentrique, contrôlé, avec répartition au hasard, 488 patients ont été distribués dans deux groupes. Une stratégie précoce : instauration d’une épuration extra-rénale (EER) dans les douze heures après la mise en évidence d’une dégradation de la fonction rénale, a été mise en œuvre dans le premier groupe (n = 246). La stratégie utilisée dans le second groupe (n = 242) a été plus tardive : instauration de l'EER après quarante-huit heures d’altération de la fonction rénale [...] Le critère de jugement principal a été la mortalité au 90e jour [...]
Lire l’article - MediaMed
Paul Desforges 24 03 2019
Barbar SD, et al.; IDEAL-ICU Trial Investigators and the CRICS TRIGGERSEP Network. Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis. N Engl J Med. 2018 Oct 11;379(15):1431-1442. doi: 10.1056/NEJMoa1803213.
Voir aussi : Répétition du qSOFA : une arme contre le sepsis ? Corticoïdes et choc septique : le débat continue (ADRENAL, APPROCHSS)
X-ray of eight-months fetus–arteries injected with bismuth. Obstetrics for nurses. 1922. Frontispiece.
Internet Archive Via nemfrog
New Studies Investigate How COVID-19 May Impact Breast Milk and Pregnancy
Researchers at University of California San Diego School of Medicine are launching a pair of studies to answer critical questions regarding the roles COVID-19 may play in breast milk and pregnancy.
The first study, led by Lars Bode, PhD, principal investigator and director of UC San Diego’s Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), will try to answer the questions, Is COVID-19 transmitted via human milk and can breast milk protect infants from COVID-19? ?
The second study, led by Christina Chambers, PhD, MPH, professor in the Department of Pediatrics at UC San Diego School of Medicine and director of Organization of Teratology Information Specialists, will focus on the short-and long-term effects of the novel coronavirus in pregnancy and breastfeeding.
Disinfectant. Don’t Spread Germs. 1948.
Internet Archive
Via nemfrogfilms
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Un lien entre l’utilisation de fluoroquinolones et le risque de dissection ou d'anévrisme aortique a été cherché dans le cadre de cette étude nationale suédoise de cohorte. - MediaMed Information
Traitement par les fluoroquinolones et risque accru de dissection et d'anévrisme aortique
Les fluoroquinolones sont des antibiotiques très utilisés à travers le monde. Leur utilisation est associée à un risque connu de pathologies tendineuses [...]
Un lien entre l’utilisation de fluoroquinolones et le risque de dissection ou d'anévrisme aortique a été cherché dans le cadre de cette étude nationale suédoise de cohorte en comparant l’usage des fluoroquinolones à celui d’un autre antibiotique : l’amoxicilline.
Crédit image : Iroises communication
Entre juillet 2006 et décembre 2013, 360 088 utilisations de traitement par fluoroquinolones (dont 78 % de ciprofloxacine) ont été comparées à celles d’amoxicilline (ratio 1:1). [...]
Lire l’article - MediaMed
Marjolaine Baude 06 01 2019
Source
Pasternak B, et al. Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study. BMJ 2018;360:k678.
Voir aussi : - Fluoroquinolones : attention au risque vasculaire une autre lecture du même travail par Paul Desforges.
It’s Friday, which means it’s time to showcase another frontispiece! This one comes from the 1690 edition of Anton Nuck’s Sialographia et ductuum aquosorum anatome nova. Nuck (1650-1692) earned his medical degree at the University of Leiden, where he later became Professor of Anatomy. He pioneered a method of injecting marker substances into the salivary glands via their ducts and blood vessels, which he referred to as “sialography.”
In this frontispiece, the figure crowned with a laurel wreath holds a book open to the motto Nosce te ipsum: Know thyself. This phrase can be read as a summation of the purpose of anatomical investigation: that in developing an understanding of the human body, we will come to know ourselves.
