I'd love to see a full Ducktales adaptation of the Odyssey, in the same vein as other cartoon adaptations of classic literature like Mickey's Christmas Carol or The Three Mouseketeers. I've even come up with the full cast for it.
Della's obviously the perfect character to play Odysseus, what with the whole ten-year quest to return home to her family including children she's been separated from since infancy, and the boys can collectively be Telemachus. Donald and Scrooge best fit the roles of Penelope and Laertes, but it's debatable who fits which one better. Both of them sort of do something akin to Laertes going off to mourn in the countryside, and they each fit a different aspect of Penelope- Donald for being the one to raise the boys, and Scrooge for being the one who has the wealth and power the suitors would be after. I think Donald makes more sense for Penelope and Scrooge for Laertes, but they could go either way. Hortense can be Anticleia, fitting as she's generally presumed to have died at some point before the show starts much like how Anticleia dies before the Odyssey starts. Aside from the boys and Hortense, the relationships between the Ducktales characters are different from the Odyssey characters, but I picked them for how they fit the narrative role, not how exactly they're related to each other.
Conveniently, the family has the same number of non-related (more or less) household residents that Odysseus has household servants (well, slaves, really- ancient Greece was not a nice place to live) who aid the protagonists. Beakley and Webby can be Eumaios and Philoitius- I don't think it really matters which is which, though I'd be slightly inclined to make Webby Eumaios on the basis that she spends a lot more time with the boys, much like how Telemachus and Odysseus spend a while with Eumaios in the poem- and Duckworth can be Eurycleia.
The gods present an interesting wrinkle here. Some of the Greek gods do actually exist as characters in Ducktales. They could theoretically just play themselves. However, in most cases, there are other characters better suited to the roles. Except in one of those cases, that other character is a different Greek god. I think Selene is the best choice for Athena, as a divine mentor to Della/Odysseus who then goes on to offer aid to Dewey/Telemachus. I'd go with Goldie for Hermes (because thieves), and Zeus can just be Zeus. Ironically, the Odyssey is actually one of the more reasonable portrayals of Zeus, even among its immediate contemporaries (Iliad Zeus is every bit the petty, vengeful asshole we know him as today), so Ducktales Zeus isn't all that great a fit, but I can't think of any better characters for the role, so it might as well just be Zeus as himself.
The suitors (who are presumably not actually seeking Donald's, or even Scrooge's, hand in marriage here- though I'm also in favor of having Storkules show up among them completely unaware of what the others are after while he is actually trying to marry Donald) can be made up of various villains. I think the best choice for Antinous, their leader, is Glomgold. Admittedly, this would work somewhat better if Scrooge was Penelope, but Glomgold still works and I have other plans for any villain who might fit this role better. Most of the suitors are pretty well interchangeable and could be any villain not otherwise assigned, but I'd go with Bouncer Beagle, arguably the most reasonable of the Ducktales antagonists, as Eurymachus, the most reasonable of the suitors. Additionally, Bradford, as one of Scrooge's associates who turned against him, can be Melanthios.
Nestor and Menelaus don't have major roles in the Odyssey, but they do show up as the people Athena sends Telemachus to in order to seek information about Odysseus. I'd make them Quackfaster and Gyro. Nestor is the most reasonable and levelheaded of the Achaean kings who fought at Troy, and while "reasonable and levelheaded" doesn't exactly describe Quackfaster, it comes closer to describing her than Gyro. Menelaus, meanwhile, is the guy who called the Trojan War in the first place, since it was his wife Paris and Aphrodite made off with, so it makes sense to cast him as Gyro, the guy who designed the Spear of Selene.
In the Odyssey, the only crewmates of Odysseus who have any significant role are Eurylochus and Elpenor. Polites and Perimedes get like two lines each, and no one else is even named. Therefore, I'm only going to bother casting Eurylochus and Elpenor. There isn't really a great fit for Eurylochus, considering Della's whole thing in the show was being alone, but Penumbra sort of works, and I can't think of any other role that would suit her better, so I'll go with her. Elpenor's whole thing in the Odyssey is being forgotten, so the obvious choice for him is what's his name, that purple guy- Drake Mallard.
There isn't really a great Ducktales equivalent for the Cicones, but most Odyssey adaptations just completely forget they exist, so we might as well just skip them too. Instead, we'll start Odysseus's adventure with the Moonlanders as the Lotus Eaters (clueless and isolated). Steelbeak is Polyphemus (big, dumb, violent), Fenton is Aeolus (a mortal granted phenomenal powers over the wind, much like how Fenton is a superhero with the Gizmosuit), FOWL is the Laestrygonians, Magica is Circe (because she's a sorcerer, of course- and just after I made that connection, I realized the implications of having Magica take Circe's role to Della's Odysseus, and now I'm picturing a scenario where non-Odyssey canon setting Della has a teen rebellion phase and starts hanging pinups of Magica on her wall to annoy Scrooge), Lena is Tiresias (the idea of Circe!Magica very begrudgingly sending Odysseus!Della to consult with Tiresias!Lena has some great comedy potential, and shadow homunculus Lena is definitely the best fit for a shade of the dead), The Moon Mite is Scylla and/or Charybdis (who are really more like a force of nature than an actual enemy for Odysseus, much like the Moon Mite for Della), Lunaris is Calypso (it's implied that Lunaris was at least knowingly hiding the Moonlanders' presence from Della specifically, and possibly that he was even intercepting and blocking her transmissions to Earth, so he definitely fits for Calypso detaining Odysseus for seven years), and Owlson is Alcinous (she's the most reasonable and level-headed character in the whole show, so she seems well-suited to offer Della food, shelter, and aid in returning home).