BOC Sciences Media

Yeast is a single-celled and versatile microorganism that is widely used in various industries, such as brewing, food, and biotechnology. However, not all yeast strains possess the desired characteristics required for optimal production. Therefore, methods of yeast strain improvement have been developed to enhance the desirable traits of yeast strains and to benefit industries involving yeast.

Stable isotope labeling with amino acids in cell culture (SILAC) technology is based on the principle that cell growth depends on essential amino acids, and uses stable isotope-labeled (13C, 15N, 2H) essential amino acids to metabolically label cellular proteins.

Supported by an in-house project management and quality team, we operate to the highest quality standards. Supported by an in-house project management and quality team, we operate to the highest quality standards. BOC Sciences has established GLP-certified laboratories that can provide GLP and non-GLP studies through predictive, exploratory and discovery toxicology. Our novel predictive and mechanical testing services include:

Provide toxicology data for re-registration dossier in accordance with the latest regulatory requirements

Create detailed comparative toxicological risk data across species

Screen candidate compounds

Help to develop products that are most beneficial to humans and the environment

BOC Sciences is going to have a free webinar on March 9th! In this presentation, Dr. Shiyue Fang will showcase experimental examples of sensitive nucleosides, including their biological roles and relationships to clinical applications, challenges related to nucleic acids synthesis containing sensitive nucleosides, and the current status of the Dim-Dmoc method developed by his research group at the Michigan Technological University that overcomes related obstacles. In addition, Dr. Fang will also share personal opinions regarding the potential applications of sensitive nucleic acids accessible by the Dim-Dmoc method.

Highlights of the presentation

1. Diverse structures of sensitive nucleosides

2. Insights on applications of sensitive nucleic acids

3. Dim-Dmoc methods for sensitive nucleic acid synthesis

The size of the market for mRNA products depends in the short term on COVID-19 vaccine sales. Between 2023 and 2025, though with the support of booster vaccine approval and wider global use, this number will go down to about $20 billion due to a decline in mainstream demand for COVID-19 vaccines and a lack of new product launches. It is estimated that the mRNA drug market is expected to grow from 2028 and reach $23 billion in 2035 with the introduction of other preventive and therapeutic vaccine products. Among them, preventive vaccines will remain the cornerstone, accounting for more than 50% of the market by 2035. Therapeutic vaccines for cancer account for about 30% and therapeutic drugs for less than 20%.

Antimicrobial peptides mainly carry out non-specific rapid killing and intracellular interference on the cell membrane of harmful pathogens and do not target specific molecular pathways, which significantly reduces the probability of bacterial resistance to antimicrobial peptides. Therefore, it is of great significance to apply antimicrobial peptides to the clinical research of antimicrobial drugs.

PseudoUridine (abbreviated by Ψ) or 5-ribosyluracil, is an isomer of uridine (U), and unlike uracil in uridine, which is linked to ribose by a carbon-nitrogen bond (C1-N1), uridine and ribose of Ψ are linked by a carbon-carbon bond (C1-C5). Uracil and ribose are connected by a C1-C5 bond in Ψ, so its structure is more flexible and has an additional site for hydrogen bonding than uridine, and the overlap effect in RNA is higher than that of uridine.

Liposome Preparation 2!

What is mRNA Vaccine?

Liposomes are small artificial vesicles of spherical shape that can be formed by cholesterol and natural non-toxic phospholipids. BOC Sciences, your liposomal partner, will take you through the hydration method for liposome preparation.