Diversity in the Pokeverse

Ilima is a gay trans demiboy and has an unrequited crush on Grimsley (kind of celebrity crush style), who is openly bi and polyamorous.

Gladion is gay and demiagender and he struggles with anxiety. He calms himself down from panic attacks using Silvally's fur as a comforting texture. Ilima is nonbinary, gay, and autistic, with a special interest in Pokemon Battling, Normal Type Pokemon and the Eeveelutions. Gladion and Ilima are dating, though Gladion's kept it a secret from everyone excluding Lillie, who supports him wholeheartedly.

Ilima is amab nonbinary, and every in-game instance of them being referred to with he/him pronouns is due to either the person referring to them not knowing that they're nonbinary or not understanding that they prefer they/them

The Pokémon world has a much tighter diagnostic criteria for autism than our world; by our standards, most if not all Pokémon characters would be autistic

Bugsy is a trans girl, but she can't come out due to transphobic parents. She tries to look as feminine as possible to cope with dysphoria, and she hates having to 'correct' people who 'mistake' her for a girl

Lusamine has ptsd resulting from losing Mohn. In SuMo canon, she repressed the memories as a result of Nihilego’s influence, and only uncovered them after going to Kanto with Lillie. In USUM canon, she never moved on until after the events of the game. This also contributed to severe depression and worsening schizophrenia (which she was diagnosed with previously but was being treated for it).

Steven Stone is autistic and has a lot of difficulty telling the difference between friendly teasing and bullying due to his low social skills. This has led to him having a rocky relationship with his father (who doesn't understand why he takes it so personally) and has caused him to lost a lot of friends after presuming they hated him because of one joking comment.

Leaf is autistic, and at some point during school one of her special interests was a TV show designed for girls much younger than her, leading to her classmates bullying her for it. The constant bullying led to her developing depression and social anxiety and eventually contributed to her decision to become a Pokémon Trainer to get away from it all.

Moon (I always imagined that Sun was the player in Sun and Moon was the player in Moon, for obvious reasons) is narcoleptic. She finds it easier to stay awake during the night, which is why she normally does most of her training late at night.

Cynthia is umbreonkin.

Hau is pansexual and in a polygamous relationship with both Sun and Gladion, who are bisexual and gay respectively. Moon and Lillie are both lesbians and dating, and Lillie's in a quasi/queerplatonic relationship with Sun and Hau.

I'm not sure if you accept headcanons about the manga, but I fell in love with this idea yesterday and I have to post it somewhere: Yellow from Pokémon Adventures is actually a trans boy, and that's why he didn't have a problem with presenting masculine when Green/Blue (depending on whether you read the English or Japanese version) told him to and why he continued to present masculine long after it was necessary.

Meyer (XYZ anime) is a traumagenic system. Blaziken Mask is his Protector alter, who normally fronts at night.

Lillie is a trans lesbian