This is probably the most useful take I’ve seen from a medical professional online. I’m adding some extra notes because there are a lot of options out there and it’s REALLY confusing sometimes, but there are only a few actual ingredients in most over the counter cold meds. Here’s some extra info you may find valuable:
Generic meds are fine, there’s no need to buy name brands.
Motrin and Advil are both ibuprofen, so you can look for the generic of either
Guaifenesin is the most standard expectorant on the market, it’s in a huge number of cold medicines. Regular Mucinex is just plan guaifenesin with no cough suppressant.
The primary ingredient in Robitussin is dextromethorphan and it is a cough suppressant.
You will see a combination of those two ingredients in pretty much every over the counter cold/cough meds, including DayQuil/NyQuil.
Other ingredients you’re likely to run across, and what they do:
Doxylamine Succinate - it’s an antihistamine, but what it’s used for in most of these products is actually to make you sleepy. You’ll find this in NyQuil and other “nighttime” cold meds.
Pseudoephedrine - You’ve probably heard of this as Sudafed, and it’s basically the OG of decongestants. In the US you have to be 18 or older to purchase it, and it can only be purchased from behind the counter at a pharmacy. Why is it so hard to get? Because apparently people started buying it in large quantities to make meth. Good times, right? Some people find that Sudafed makes them jittery and awake, but I’ve never had that issue and find it works the best of decongestants I’ve tried. Go buy this NOW if you want to have it in case you get sick, it can completely disappear during cold and flu season.
Phenylephrine - this is “new” Sudafed. When you’re looking at cold products that are on the shelves that say they have a decongestant, this is what they’re going to have in it. To me this is the useless cousin of pseudoephedrine, but that’s just me.
Hope this helps some folks. As a cancer survivor and diabetic I get sick A LOT so I usually keep this stuff on hand and I’ve learned a lot about generic ingredients.