Mar 11, 2020
"Sirt-food diyeti hakkında bilinmeyenler" https://yogbe.com/diyet/sirt-food-diyeti-hakkinda-bilinmeyenler/
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"Sirt-food diyeti hakkında bilinmeyenler" https://yogbe.com/diyet/sirt-food-diyeti-hakkinda-bilinmeyenler/
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The apelinergic system and its relevance to endocrinology and diabetes has become of major importance to the global chronic disease epidemic.
Sirtuin’s Role in Longevity
Sirtuin’s Role in Longevity
The Next Paradigm Shift is a new approach to health and wellness that relies on cutting-edge research and well-documented natural techniques to improve well-being and increase longevity. An invitation-only program, The Next Paradigm Shift was founded by a leading research scientist and works to stimulate natural healing mechanisms in the body to promote healing. The sirtuinfamily of proteins has…
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Did you know family studies found that roughly 25 % of the variation in human longevity is due to genetic factors!? —— Researchers have identified specific genes that can impact symptoms of aging, as well as longevity genes that actually play a role in the body’s defenses against aging ——- The longevity genes being researched are called “sirtuins”; there are seven sirtuins in mammals, SIRT1 to SIRT7, and they are made by almost every cell in the body ——- Sirtuin 6 (SIRT6) is responsible for allowing more efficient DNA repair to occur in those with longer lifespans, which is being studied to see how certain dietary/nutritive and lifestyle factors can be used to help prevent age-related disease ——- As we get older, our DNA is more prone to breaks, which can cause our genes to mutate or get “rearranged”, which has been found to be hallmarks of cancer progression and general aging —— DNA repair in general plays in lifespan, as certain lifestyle factors (such as smoking, excessive oxidative damage, environmental toxins etc ) can speed up double-strand breaks in DNA —— Research in mice have found that activating sirtuins can improve DNA repair, boost memory and increase exercise endurance —— SIRT6 is many times called the "longevity gene" because it plays a role “recruiting” proteins and enzymes that repair broken DNA, in fact, mice without this gene actually age prematurely, while mice with extra copies can live longer —— #briannaapproved #Sirtuin #longevitygenes #epigenetics #genes #plantcompounds #stress #oxidativedamage #DNA #toxins #mitochondria #cellhealth (at Cafe Volan) https://www.instagram.com/p/B4sAMIBA86h/?igshid=7du886g4zygv
Aging affects us all and we do not understand it completely yet. Check out our latest blog to know how our cells change with age and how mitochondria are at the center of age related studies! Link here: http://www.biolegend.com/newsdetail/3853/
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The Sirtfood Diet - 3 kg Less For 7 days
The Sirtfood Diet – 3 kg Less For 7 days
Believe it or not, there is now a diet that allows and encourages the consumption of chocolate, red wine and coffee.
If you enjoy these foods, then you worship Sirtfood Diet.
Designed and tested by nutritionists Aidan Goggins and Glen Matten, this diet has presented the book: “The Sirtfood diet: The revolutionary plan for health and weight loss”
This diet is based on consumption of foods that…
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Amyloid precursor protein (APP) has been modified by β and γ-secretase that cause amyloid deposits (plaques) in neuronal cells. Glyceraldhyde-derived AGEs has been identified as a major source of neurotoxicity in Alzheimer’s disease (AD). In a previous study, we demonstrated that glyceraldehyde-derived AGEs increase APP and Aβ via ROS. Furthermore, the combination of AGEs and Aβ has been shown to enhance neurotoxicity. In mice, APP expression is increased by tail vein injection of AGEs. This evidence suggests a correlation between AGEs and the development of AD. However, the role played by AGEs in the pathogenesis of AD remains unclear. In this report, we demonstrate that AGEs up-regulate APP processing protein (BACE and PS1) and Sirt1 expression via ROS, but do not affect the expression of downstream antioxidant genes HO-1 and NQO-1. Moreover, we found that AGEs increase GRP78 expression and enhance the cell death-related pathway p53, bcl-2/bax ratio, caspase 3. These results indicate that AGEs impair the neuroprotective effects of Sirt1 and lead to neuronal cell death via ER stress. Our findings suggest that AGEs increase ROS production, which stimulates downstream pathways related to APP processing, Aβ production, Sirt1, and GRP78, resulting in the up-regulation of cell death related pathway. This in-turn enhances neuronal cell death, which leads to the development of AD.
Amyloid precursor protein (APP) has been modified by β and γ-secretase that cause amyloid deposits (plaques) in neuronal cells.
Glyceraldhyde-derived AGEs has been identified as a major source of neurotoxicity in Alzheimer’s disease (AD).
In a previous study, we demonstrated that glyceraldehyde-derived AGEs increase APP and Aβ via ROS.
Furthermore, the combination of AGEs and Aβ has been shown to enhance neurotoxicity.
In mice, APP expression is increased by tail vein injection of AGEs.
This evidence suggests a correlation between AGEs and the development of AD.
However, the role played by AGEs in the pathogenesis of AD remains unclear.
In this report, we demonstrate that AGEs up-regulate APP processing protein (BACE and PS1) and Sirt1 expression via ROS,
but do not affect the expression of downstream antioxidant genes HO-1 and NQO-1.
Moreover, we found that AGEs increase :
GRP78 expression and enhance the cell death-related pathway p53, bcl-2/bax ratio, caspase 3.
These results indicate that AGEs impair the neuroprotective effects of Sirt1 and lead to neuronal cell death via ER stress. Our findings suggest that AGEs increase ROS production, which stimulates downstream pathways related to APP processing, Aβ production, Sirt1, and GRP78, resulting in the up-regulation of cell death related pathway. This in-turn enhances neuronal cell death, which leads to the development of AD.
Activating a protein called Sirtuin 1 (SIRT1) extends lifespan, delays the onset of age-related metabolic diseases, and improves general health in mice. Researchers in this study tested the effects of a small molecule that activates SIRT1, called SIRT1720, on the health and lifespan of man. They fed the animals a standard diet supplemented with SRT1720 beginning at six months of age for the remainder of their lives.
Results: The findings show evidence that supplementation of SRT1720 significantly extended the average lifespan of move by 8.8%. Furthermore, supplementation reduced body weight and body fat percentage, while improving muscle function and motor coordination throughout the animals' lives.
Conclusion: The findings point to a potentially promising strategy for improving health and longevity. SIRT1 is known to play an important role in maintaining metabolic balance in multiple tissues, and studies in various organisms have shown that activating the protein can lead to many health benefits. Also, drugs that increase SIRT1 activity have been found to slow the onset of aging and delay age-associated diseases in several animal models.
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