Dec 17, 2019
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scanners 1981
Anya is live and ready to show you everything. Watch her strip, dance, and perform exclusive shows just for you. Interact in real-time and make your fantasies come true.
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Si le neurone lui-même pratique la polymédication, peut-être le psychopharmacologue devrait-il faire de même
Psychopharmacologie essentielle, Stephen Stahl
Okay time to catch up on pharm, i have been pushing it back for 2 weeks now
omg if it's this ssri switch thats making me suicidal
I dO nOt KnOwS.......
Stuff I Learned: EM Lectures
Pain Management
SSRI + tramadol = SSRI syndrome
Mental: anxiety, restlessness
Autonomic: hypertension, tachycardia, vomiting, diarrhea
Neuromuscular: hyperreflexia, rigidity, myoclonus
MAOI + pethidine = hypertensive crisis and SSRI syndrome
Tramadol lowers threshold for seizure
Buscopan = hyoscine
NSAIDs: dose for peak analgesic effect is lower than dose for peak anti-inflammatory effect
Methocarbamol is a muscle relaxant
Drugs for migraine
Maxolon = metoclopramide
Stemetil = prochlorperazine
Drug for cystitis: pyridium (phenazopyridine)
Medicolegal & Psychosocial Issues
Bruises can move (by gravity), and do not indicate the site of injury
Bruises change color
Reddish blue
Black purple
Greenish brown
Yellow
Fade
Abrasion is a breach of epidermis of skin due to friction with rough or pointed surfaces
Laceration: splitting of skin by blunt force; has bruising of wound edge and underlying tissue bridge
Cut or incision is splitting of skin by a sharp instrument with little bruising
Gunshot wound
Exit wound is larger than entry wound and the wound is more ragged
Entry wound may have an abrasion collar or gunpowder on skin
Police is not supposed to shoot from the back
Wound Management
Primary closure: 6-8 hours
Not for primary healing: abscess, ulcer, contamination, delayed wound, puncture wound, bite wound
Techniques for wound closure
Layer matching
Wound eversion: 90 degree needle insertion, vertical mattress
Wound tension
Dead space
Prophylactic antibiotics usually not necessary
Anti-rabies vaccine (ARV) is given on days 1, 3, 7, 14
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Pharmaco Kinesis, Frost & Sullivan Position Paper
Pharmaco Kinesis, Frost & Sullivan Position Paper
Pharmaco Kinesis, Frost & Sullivan Position Paper
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i dun even know what am i studying now
Graffner et al. (Graffner C, Johnsson G, Sjögren J. Pharmacokinetics of procainamide intravenously and orally as conventional and slow-release tablets. Clin Pharmacol Ther 1975;17:414–423), in evaluating different dosage forms of procainamide obtained the following AUC and cumulative urine excretion data listed in Table 6-2. Plasma and urine were collected for 48 hr following drug administration.Table 6-2 Procainamide Data Following i.v. and Oral Administration
Estimate both bioavailability and relative bioavailability of Formulation 2 from both plasma and urine data. What are the assumptions made in your calculations? Hide Solution
From AUC analysis, F = 0.76; Frel = 0.95.
From Ae∞ analysis, F = 0.83; Frel = 0.95.
Plasma
Urine
Assumptions made are:
CL and fe do not vary between treatments.
Estimates of AUC and Ae∞ are accurate (e.g., no missed urine collections, correct extrapolations to infinity).
The half-life of procainamide found in this study was 2.7 hr. Was the urine collected over a long enough time interval to obtain a good estimate of the cumulative amount excreted at infinite time? Show Solution
Do the renal clearance values of procainamide vary much among the three treatments? Hide Solution
CLR values (Ae∞/AUC) are 25, 28, and 28 L/hr for the i.v. formulation 1 and formulation 2 treatments, respectively. The differences among them are small and probably insignificant (only mean data are shown).